Yeni adipokinler: Leptin, adiponektin ve omentin

Aktas, Gulali; ŞİT, Mustafa; TEKÇE, Hikmet

Yeni adipokinler: Leptin, adiponektin ve omentin

Gülali AKTAŞ, (Abant İzzet Baysal Üniversitesi, Düzce Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bolu, Türkiye)

Mustafa ŞİT, (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Bolu, Türkiye)

Hikmet TEKÇE (Abant İzzet Baysal Üniversitesi, Düzce Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bolu, Türkiye)

Abant Tıp Dergisi

13 3

Yıl: 2013 Cilt: 2 Sayı: 1 Sayfa Aralığı: 56 - 62 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Yeni adipokinler: Leptin, adiponektin ve omentin

Öz:

Yağ dokusu günümüzde enerji metabolizmasının önemli birparçası olarak kabul edilmektedir. Salgıladığı adipokinlerbeslenme, iştah, enerji dengesi, insülin ve glukoz metab olizması, lipid metabolizması, kan basıncının düzenlenmesi,vasküler remodeling, koagülasyon, inflamasyon gibi vücudunbirçok fizyolojik işleminde rol oynamaktadırlar. Leptin, çevresel etmenler ve genler beraberce vücut yağ miktarınıdüzenlemektedirler. Leptin molekülünün şu ana kadar iştah,vücut ağırlığı, enerji dengesi ve bir takım nöroendokrinfonksiyonlarla ilişkili olduğu saptanmıştır. Yağ dokusundansalgılanan adiponektini kodlayan gen 3. kromozom üzerindeolup bulunduğu loküs tip 2 diyabet ve vücut yağlanmasındansorumlu tutulan loküse yakındır. Obez bireylerde omentin1in hem yağ dokusundaki gen ekspresyonu ve hem deplazma seviyeleri azalmaktadır. Bel çevresi, vücut kitle i ndeksi ve leptin seviyleri gibi obezite ile ilişkili markerlar ileomentin seviyesi ters orantılıdır. Adiponektinin anti -aterojenik ve insülin duyarlığını artırıcı etkileri mevcuttur. Bunedenle yağ dokusu kökenli bu adipokinleri hedef alan ilaçtedavileri insülin duyarlılığını artırabilir ayrıca aterosklerozakarşı koruyucu etki gösterebilir.

Anahtar Kelime:

Konular: Cerrahi

New adipokines: Leptin, adiponectin and omentin

Öz:

Adipose tissue is now considered as an important part ofenergy metabolism. Adipokines secreted by adipose tissueplay decisive role in many physiological process such asenergy balance, insulin and glucose metabolism, lipid m etabolism, regulation blood pressure, vascular remodeling,coagulation and inflammation. The amount of body fatorganized by leptin, environmental factors and genes together. Leptin molecule was found to be associated withapp e tite, body weight, energy balance and a number ofneuroendocrine functions so far. The gene encoding ad iponectin is located in a loci in chromosome 3 which is closeto the locus considered responsible for type 2 diabetes andsteatosis. Gene expression of omentin -1 and plasma levelsof omentin decreased in obese subjects. Obesity relatedmarkers such as, waist circumference, body mass index andleptin levels are negatively correlated with plasma omentinlevels. Adiponectin has anti -atherogenic and insulin sensitizing effects. Therefore, drugs targeting adipokines that d erived from adipose tissue may increase insulin sensitivityand may also have protective effect against atherosclerosis.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Aktas G, ŞİT M, TEKÇE H (2013). Yeni adipokinler: Leptin, adiponektin ve omentin. , 56 - 62.
Chicago	Aktas Gulali,ŞİT Mustafa,TEKÇE Hikmet Yeni adipokinler: Leptin, adiponektin ve omentin. (2013): 56 - 62.
MLA	Aktas Gulali,ŞİT Mustafa,TEKÇE Hikmet Yeni adipokinler: Leptin, adiponektin ve omentin. , 2013, ss.56 - 62.
AMA	Aktas G,ŞİT M,TEKÇE H Yeni adipokinler: Leptin, adiponektin ve omentin. . 2013; 56 - 62.
Vancouver	Aktas G,ŞİT M,TEKÇE H Yeni adipokinler: Leptin, adiponektin ve omentin. . 2013; 56 - 62.
IEEE	Aktas G,ŞİT M,TEKÇE H "Yeni adipokinler: Leptin, adiponektin ve omentin." , ss.56 - 62, 2013.
ISNAD	Aktas, Gulali vd. "Yeni adipokinler: Leptin, adiponektin ve omentin". (2013), 56-62.

APA	Aktas G, ŞİT M, TEKÇE H (2013). Yeni adipokinler: Leptin, adiponektin ve omentin. Abant Tıp Dergisi, 2(1), 56 - 62.
Chicago	Aktas Gulali,ŞİT Mustafa,TEKÇE Hikmet Yeni adipokinler: Leptin, adiponektin ve omentin. Abant Tıp Dergisi 2, no.1 (2013): 56 - 62.
MLA	Aktas Gulali,ŞİT Mustafa,TEKÇE Hikmet Yeni adipokinler: Leptin, adiponektin ve omentin. Abant Tıp Dergisi, vol.2, no.1, 2013, ss.56 - 62.
AMA	Aktas G,ŞİT M,TEKÇE H Yeni adipokinler: Leptin, adiponektin ve omentin. Abant Tıp Dergisi. 2013; 2(1): 56 - 62.
Vancouver	Aktas G,ŞİT M,TEKÇE H Yeni adipokinler: Leptin, adiponektin ve omentin. Abant Tıp Dergisi. 2013; 2(1): 56 - 62.
IEEE	Aktas G,ŞİT M,TEKÇE H "Yeni adipokinler: Leptin, adiponektin ve omentin." Abant Tıp Dergisi, 2, ss.56 - 62, 2013.
ISNAD	Aktas, Gulali vd. "Yeni adipokinler: Leptin, adiponektin ve omentin". Abant Tıp Dergisi 2/1 (2013), 56-62.