The endocannabinoid system as a potential therapeutic target for pain modulation

Ulugol, Ahmet

The endocannabinoid system as a potential therapeutic target for pain modulation

Ahmet ULUGÖL (Trakya Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji, Edirne, Türkiye)

Balkan Medical Journal

2 0

Yıl: 2014 Cilt: 31 Sayı: 2 Sayfa Aralığı: 115 - 120 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The endocannabinoid system as a potential therapeutic target for pain modulation

Öz:

Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the enzymes playing a role in endocannabinoid metabolism. Nowadays, research has focused on the inhibition of these degradative enzymes and the elevation of endocannabinoid tonus locally; special emphasis is given on multi-target analgesia compounds, where one of the targets is the endocannabinoid degrading enzyme. In this review, I provide an overview of the current understanding about the processes accounting for the biosynthesis, transport and metabolism of endocannabinoids, and pharmacological approaches and potential therapeutic applications in this area, regarding the use of drugs elevating endocannabinoid levels in pain conditions

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APA	Ulugol A (2014). The endocannabinoid system as a potential therapeutic target for pain modulation. , 115 - 120.
Chicago	Ulugol Ahmet The endocannabinoid system as a potential therapeutic target for pain modulation. (2014): 115 - 120.
MLA	Ulugol Ahmet The endocannabinoid system as a potential therapeutic target for pain modulation. , 2014, ss.115 - 120.
AMA	Ulugol A The endocannabinoid system as a potential therapeutic target for pain modulation. . 2014; 115 - 120.
Vancouver	Ulugol A The endocannabinoid system as a potential therapeutic target for pain modulation. . 2014; 115 - 120.
IEEE	Ulugol A "The endocannabinoid system as a potential therapeutic target for pain modulation." , ss.115 - 120, 2014.
ISNAD	Ulugol, Ahmet. "The endocannabinoid system as a potential therapeutic target for pain modulation". (2014), 115-120.

APA	Ulugol A (2014). The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Medical Journal, 31(2), 115 - 120.
Chicago	Ulugol Ahmet The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Medical Journal 31, no.2 (2014): 115 - 120.
MLA	Ulugol Ahmet The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Medical Journal, vol.31, no.2, 2014, ss.115 - 120.
AMA	Ulugol A The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Medical Journal. 2014; 31(2): 115 - 120.
Vancouver	Ulugol A The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Medical Journal. 2014; 31(2): 115 - 120.
IEEE	Ulugol A "The endocannabinoid system as a potential therapeutic target for pain modulation." Balkan Medical Journal, 31, ss.115 - 120, 2014.
ISNAD	Ulugol, Ahmet. "The endocannabinoid system as a potential therapeutic target for pain modulation". Balkan Medical Journal 31/2 (2014), 115-120.