Yıl: 2013 Cilt: 59 Sayı: 2 Sayfa Aralığı: 123 - 127 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey

Öz:
Amaç: Romatoid Artrit (RA)in genetik yatkınlığında HLA-DRB1 alelleriönemli bir yere sahiptir. Değişik etnik gruplarda ve coğrafik dağılımlardaHLA-DRB1 ile RA ilişkisi farklılık göstermektedir. Bu çalışmanın amacıGüneydoğu Anadolu Bölgesi Türk popülasyonundaki RAlı hastalarda,HLA-DRB1 alel dağılımının belirlenmesidir.Gereç ve Yöntem: RA tanısı almış 96 hasta ve kontrol grubu olarak 84sağlıklı kişi çalışmaya dahil edildi. HLA-DRB1 tip ve subtipleri polymerasechain reaction with sequence specific primers (PCR-SSP) metodukullanılarak belirlendi. Gruplar arası HLA-DRB1 tip ve bazı subtip frekanslarıkarşılaştırıldı.Bulgular: RAlı hastalarda, kontrol grubu ile kıyaslandığında, DRB1*10aleli istatistiksel olarak anlamlı yüksek bulundu (p=0,001). RAlı hastalardaDRB1*07 ve DRB1*11 alelleri ise istatistiksel olarak anlamlı düşük bulundu(p<0,001 ve p=0,02, sırasıyla). RAlı hasta grubunda DRB1*0401,DRB1*0408 ve DRB1*1001 alt tipleri istatistiksel olarak anlamlı yüksek(p=0,04, p=0,01, p=0,005, sırasıyla); DRB1*0402, DRB1*0403 veDRB1*0701 alt tipleri ise istatistiksel olarak anlamlı düşük bulundu (p=0,01,p=0,02, p<0,001, sırasıyla).Sonuç: Bu çalışma Türkiyenin Güneydoğu Anadolu Bölgesinde HLA-DRB1dağılımını ortaya koymaktadır. DRB1*10 tip ve DRB1*0401, DRB1*0408,DRB1*1001 subtipleri RA ile ilişkili bulunmuştur. DRB1*07, BRB1*11 tiplerive DRB1 *0402, DRB1*0403, DRB1*0701 subtipleri koruyucu alel ve alttipleri olarak kabul edilmiştir. Türk Fiz T p Re­hab Derg 2013;59:123-7.
Anahtar Kelime:

Konular: Rehabilitasyon

Türkiye nin Güneydoğu Anadolu Bölgesinde Tersiyer bir merkezdeki romatoid artritli hastalarda HLA-DRB1 Alel Dağılımı

Öz:
Objective: The HLA-DRB1 alleles play an important role in the genetic predisposition to rheumatoid arthritis (RA). The relationship between HLA-DRB1 and rheumatoid arthritis show differences according to various ethnic groups and geographical distributions. The aim of this study was to determine the distribution of HLA-DRB1 among the Turkish RA patient population in the Southeastern Anatolia Region.Materials and Methods: 96 patients diagnosed with RA and a control group consisting of 84 healthy individuals were enrolled in the study. The HLA-DRB1 type and subtypes were specified using the polymerase chain reaction with sequence specific primers (PCR-SSP) method. The between- group HLA-DRB1 type and certain subtype frequencies were compared.Results: The DRB1*10 alleles were found to be statistically significantly higher in patients with RA compared to the control group (p=0.001). However, the DRB1*07 and DRB1*11 alleles were statistically significantly lower in patients with RA (p<0.001 and p=0.02, respectively). In the RA patient group, the DRB1*0401, DRB1*0408 and DRB1*1001 subtypes were found to be statistically significantly higher (p=0.04, p=0.01, p=0.005, respectively), while the DRB1*0402, DRB1*0403 and DRB1*0701 subtypes were statistically significantly lower (p=0.01, p=0.02, p<0.001, respectively).Conclusion: This study has revealed the HLA-DRB1 distribution in the Southeastern Anatolia Region of Turkey. DRB1*10 type and DRB1*0401, DRB1*0408, DRB1*1001 subtypes were observed to be related with RA. DRB1*07, BRB1*11 types and DRB1 *0402, DRB1*0403, DRB1*0701 subtypes were accepted as protective alleles and subtypes. Turk J Phys Med Rehab 2013;59:123-7.
Anahtar Kelime:

Konular: Rehabilitasyon
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA batmaz i, Sarıyıldız M, Dilek B, NAS K, ÇEVİK R, YILDIZ İ, AYYILDIZ M (2013). HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. , 123 - 127.
Chicago batmaz ibrahim,Sarıyıldız Mustafa Akif,Dilek Banu,NAS Kemal,ÇEVİK REMZİ,YILDIZ İSMAİL,AYYILDIZ MEHMET ORHAN HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. (2013): 123 - 127.
MLA batmaz ibrahim,Sarıyıldız Mustafa Akif,Dilek Banu,NAS Kemal,ÇEVİK REMZİ,YILDIZ İSMAİL,AYYILDIZ MEHMET ORHAN HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. , 2013, ss.123 - 127.
AMA batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. . 2013; 123 - 127.
Vancouver batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. . 2013; 123 - 127.
IEEE batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M "HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey." , ss.123 - 127, 2013.
ISNAD batmaz, ibrahim vd. "HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey". (2013), 123-127.
APA batmaz i, Sarıyıldız M, Dilek B, NAS K, ÇEVİK R, YILDIZ İ, AYYILDIZ M (2013). HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 59(2), 123 - 127.
Chicago batmaz ibrahim,Sarıyıldız Mustafa Akif,Dilek Banu,NAS Kemal,ÇEVİK REMZİ,YILDIZ İSMAİL,AYYILDIZ MEHMET ORHAN HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 59, no.2 (2013): 123 - 127.
MLA batmaz ibrahim,Sarıyıldız Mustafa Akif,Dilek Banu,NAS Kemal,ÇEVİK REMZİ,YILDIZ İSMAİL,AYYILDIZ MEHMET ORHAN HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.59, no.2, 2013, ss.123 - 127.
AMA batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2013; 59(2): 123 - 127.
Vancouver batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2013; 59(2): 123 - 127.
IEEE batmaz i,Sarıyıldız M,Dilek B,NAS K,ÇEVİK R,YILDIZ İ,AYYILDIZ M "HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 59, ss.123 - 127, 2013.
ISNAD batmaz, ibrahim vd. "HLA-DRB1 Alleles distribution in patients with rheumatoid arthritis in a tertiary center in the southeastern anatolia region of Turkey". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 59/2 (2013), 123-127.