Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris

BOSTAN, Mehmet; TEMİZ, Ahmet; ERDOĞAN, Turan; ÇANĞA, Aytun; ÇETİN, Mustafa; UĞURLU, Yavuz; ŞATIROĞLU, Ömer; çiçek, yüksel gülen; KOCAMAN, Sinan Altın; Akgul, Ozgur

Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris

Mustafa ÇETİN, (Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Rize, Türkiye)

Sinan Altın KOCAMAN, (Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Rize, Türkiye)

Mehmet BOSTAN, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Aytun ÇANĞA, (Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Rize, Türkiye)

Yüksel ÇİÇEK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Turan ERDOĞAN, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Ömer ŞATIROĞLU, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Özgür AKGÜL, (Mehmet Akif Ersoy Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Burdur, Türkiye)

Ahmet TEMİZ, (Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Rize, Türkiye)

Yavuz UĞURLU (Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Rize, Türkiye)

European Journal of General Medicine

5 1

Yıl: 2012 Cilt: 9 Sayı: 1 Sayfa Aralığı: 7 - 13 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris

Öz:

Kırmızı kan hücresi dağılım genişliği ve vasküler olaylar arasındaki ilişki ile ilgili bazı çalışmalar olmasına karşın, RDWnin kardiyo- vasküler sistemdeki rolü konusunda bilgiler yetersizdir. Bizim amacımız anjiyografik olarak belirlenmiş koroner arter hastalık şiddet ve yaygınlığı ile RDW arasındaki ilişkiyi belirlemektir. Çalışmaya 296 hasta dahil edildi. İki yüz dokuz hastada (71%) KAH tespit edilirken (men 70%, mean yaş±SD: 61±11yıl), 87 hastada (29%) normal koroner arterler görüldü (men 48%, 52±11yıl). Yaş, hipertansiyon, diyabetes mellitus, hiperlipidemi, ailede KAH hikayesi, kreatinine, beyaz kan hücre sayımı, nötrofiller, ve RDW değerleri KAH olan hastalarda normal koronerleri olanlara göre daha yüksekti. Yüksek yoğunluklu lipoprotein KAH olanlarda daha düşüktü. RDW değerleri KAHnın şiddet ve yaygınlığına göre belirlenmiş alt gruplarda anlamlı derecede farklı idi. Koroner arter hastalığının bağımsız prediktörlerini belirlemek için yaş, cinsiyet, HT, DM, sigara içme, aile hikayesi, HPL, kreatinin, CRP, nötrofil ve RDWyi içine alan logistik regresyon analizi yaptığımızda, KAH ile yaş, cinsiyet, aile hikayesi ve RDW arasında pozitif bağımsız bir ilişki belirledik. Bizim sonuçlarımız RDW ile KAH arasında dolaşımdaki inflamatuvar hücreler ve nonspesifik inflamasyondan bağımsız olarak önemli bir ilişkiyi gösterdi. Biz RDWnin aterosklerozdaki altta yatan patolojik durumu sonuçlandıramasak ta; inanıyoruz ki bu bulgular RDWnin aterosklerozdaki rolünü araştıran çalışmalara zemin hazırlar.

Anahtar Kelime:

Konular: Cerrahi

Stabil anjina pektorisli hastalarda kırmızı kan hücresi dağılım genişliği (rdw) ve koroner arter hastalık yükü arasındaki ilişki

Öz:

Although there are several studies regarding the association between RDW and the vascular events, information is scant about possible role of RDW in cardiovascular system. We aimed to investigate whether RDW is related with the severity and extent of angiographically assessed coronary artery disease (CAD). Two hundred ninety and six stable eligible patients who had undergone coronary angiography with a suspicion of CAD were enrolled consecutively. Two hundred and nine (71%) of 296 patients had CAD (men 70%, mean age±SD: 61±11yrs) and 87 patients (29%) had normal coronary arteries (NCA) without any atherosclerotic lesion (men 48%, 52±11yrs). Red blood cell distribution width values were significantly different among the subgroups determined for the severity and extent of CAD. When 14.8% was accepted as the cut-off value for RDW, the sensitivity and the specificity for the detection of CAD was 68% and 52%. When we performed multiple logistic regression analysis to determine the independent predictors of CAD, we found a positive independent relationship between age, gender, family history of CAD and RDW and CAD. Our results show that RDW has a significant relationship with CAD independent of nonspecific inflammation and circulating inflam- matory cells. Although we cannot conclude the underlying pathologic process of RDW, we believe that these findings may pave the way for further studies searching the role of RDW in atherosclerosis.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇETİN M, KOCAMAN S, BOSTAN M, ÇANĞA A, çiçek y, ERDOĞAN T, ŞATIROĞLU Ö, Akgul O, TEMİZ A, UĞURLU Y (2012). Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. , 7 - 13.
Chicago	ÇETİN Mustafa,KOCAMAN Sinan Altın,BOSTAN Mehmet,ÇANĞA Aytun,çiçek yüksel gülen,ERDOĞAN Turan,ŞATIROĞLU Ömer,Akgul Ozgur,TEMİZ Ahmet,UĞURLU Yavuz Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. (2012): 7 - 13.
MLA	ÇETİN Mustafa,KOCAMAN Sinan Altın,BOSTAN Mehmet,ÇANĞA Aytun,çiçek yüksel gülen,ERDOĞAN Turan,ŞATIROĞLU Ömer,Akgul Ozgur,TEMİZ Ahmet,UĞURLU Yavuz Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. , 2012, ss.7 - 13.
AMA	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. . 2012; 7 - 13.
Vancouver	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. . 2012; 7 - 13.
IEEE	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y "Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris." , ss.7 - 13, 2012.
ISNAD	ÇETİN, Mustafa vd. "Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris". (2012), 7-13.

APA	ÇETİN M, KOCAMAN S, BOSTAN M, ÇANĞA A, çiçek y, ERDOĞAN T, ŞATIROĞLU Ö, Akgul O, TEMİZ A, UĞURLU Y (2012). Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. European Journal of General Medicine, 9(1), 7 - 13.
Chicago	ÇETİN Mustafa,KOCAMAN Sinan Altın,BOSTAN Mehmet,ÇANĞA Aytun,çiçek yüksel gülen,ERDOĞAN Turan,ŞATIROĞLU Ömer,Akgul Ozgur,TEMİZ Ahmet,UĞURLU Yavuz Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. European Journal of General Medicine 9, no.1 (2012): 7 - 13.
MLA	ÇETİN Mustafa,KOCAMAN Sinan Altın,BOSTAN Mehmet,ÇANĞA Aytun,çiçek yüksel gülen,ERDOĞAN Turan,ŞATIROĞLU Ömer,Akgul Ozgur,TEMİZ Ahmet,UĞURLU Yavuz Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. European Journal of General Medicine, vol.9, no.1, 2012, ss.7 - 13.
AMA	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. European Journal of General Medicine. 2012; 9(1): 7 - 13.
Vancouver	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. European Journal of General Medicine. 2012; 9(1): 7 - 13.
IEEE	ÇETİN M,KOCAMAN S,BOSTAN M,ÇANĞA A,çiçek y,ERDOĞAN T,ŞATIROĞLU Ö,Akgul O,TEMİZ A,UĞURLU Y "Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris." European Journal of General Medicine, 9, ss.7 - 13, 2012.
ISNAD	ÇETİN, Mustafa vd. "Red blood cell distribution width (rdw) and its association with coronary atherosclerotic burden in patients with stable angina pectoris". European Journal of General Medicine 9/1 (2012), 7-13.