Yıl: 2013 Cilt: 22 Sayı: 3 Sayfa Aralığı: 297 - 299 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Gabapentin toxicity in patients with chronic kidney disease; series of our cases

Öz:
Gabapentin, kronik nöropatik ağrı tedavisinde kullanılan analjezik ve anksiyolitik etkili bir antikonvülzandır. Gabapentin yalnızca böbrekten atıldığı için, böbrek yetmezliği gabapentin toksisitesi için bir risk faktörüdür. Böbrek yetmezliğinde gabapentin toksisitesi tam olarak gösterilmemiştir. Bu yazımızda, kronik böbrek yetmezlikli (KBY) beş hastada gelişen gabapentin toksistesini bildireceğiz.
Anahtar Kelime:

Konular: Cerrahi

Kronikböbrekyetmezlikli hastalardaolgu serimiz gabapentin toksisitesi;

Öz:
Gabapentin is an anticonvulsant with analgesic and anxiolytic effects and also an agent used for treatment of a variety of chronic neuropathic pains. Because gabapentin is eliminated solely through the kidney, kidney failure poses a risk for gabapentin accumulation and toxicity. Gabapentin toxicity in kidney failure hasn t been clearly proved till now. We want to emphasize the gabapentin toxicity on five cases with chronic kidney diasease at the present study.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
  • Sills GJ: The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006; 6(1): 108-113
  • Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P, Bockbrader H, Tuerck D, Busch JA, Reece PA: Pharmacokinetics of gabapentin in subjects with various degrees of renal function. Clin Pharmacol Ther 1994; 56(2): 154-159
  • Zand L, McKian KP, Qian Q: Gabapentin toxicity in patients with chronic kidney disease: A preventable cause of morbidity. Am J Med 2010; 123(4): 367-373
  • Mansfield AS, Qian Q: 71-year-old man with chronic kidney failure and sudden change of mental status. Mayo Clin Proc 2009; 84(11): 5-8
  • Dogukan A, Aygen B, Berilgen MS, Dag S, Bektas S, Gunal AI: Gabapentin-induced coma in a patient with renal failure. Hemodial Int 2006; 10(2): 168-169
  • Wong MO, Eldon MA, Keane WF, Türck D, Bockbrader HN, Underwood BA, Sedman AJ, Halstenson CE: Disposition of gabapentin in anuric subjects on hemodialysis. J Clin Pharmacol 1995; 35(6): 622-626
  • Miller A, Price G: Gabapentin toxicity in renal failure: The importance of dose adjustment. Pain Med 2009; 10(1): 190-192
  • Bookwalter T, Gitlin M: Gabapentin-induced neurologic toxicities. Pharmacotherapy 2005; 25(12): 1817-1819
  • Bassilios N, Launay-Vacher V, Khoury N, Rondeau E, Deray G, Sraer JD: Gabapentin neurotoxicity in a chronic haemodialysis patient. Nephrol Dial Transplant 2001; 16(10): 2112-2113
  • Lipson J, Lavoie S, Zimmerman D: Gabapentin-induced myopathy in 2 patients on short daily hemodialysis. Am J Kidney Dis 2005; 45: 100-104
  • Guddati AK, Zafar Z, Cheng JT, Mohan S: Treatment of gabapentin- induced myoclonus with continuous renal replacement therapy. Indian J Nephrol 2012; 22(1): 59-61
  • Hung TY, Seow VK, Chong CF, Wang TL, Chen CC: Gabapentin toxicity: An important cause of altered consciousness in patients with uraemia. Emerg Med J 2008; 25(3): 178-179
APA Karagöz A, GÜNEY I, YAZICI R, ARSLAN Ş, ALTINTEPE L (2013). Gabapentin toxicity in patients with chronic kidney disease; series of our cases. , 297 - 299.
Chicago Karagöz Ali,GÜNEY IBRAHIM,YAZICI Raziye,ARSLAN Şevket,ALTINTEPE Lütfullah Gabapentin toxicity in patients with chronic kidney disease; series of our cases. (2013): 297 - 299.
MLA Karagöz Ali,GÜNEY IBRAHIM,YAZICI Raziye,ARSLAN Şevket,ALTINTEPE Lütfullah Gabapentin toxicity in patients with chronic kidney disease; series of our cases. , 2013, ss.297 - 299.
AMA Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L Gabapentin toxicity in patients with chronic kidney disease; series of our cases. . 2013; 297 - 299.
Vancouver Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L Gabapentin toxicity in patients with chronic kidney disease; series of our cases. . 2013; 297 - 299.
IEEE Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L "Gabapentin toxicity in patients with chronic kidney disease; series of our cases." , ss.297 - 299, 2013.
ISNAD Karagöz, Ali vd. "Gabapentin toxicity in patients with chronic kidney disease; series of our cases". (2013), 297-299.
APA Karagöz A, GÜNEY I, YAZICI R, ARSLAN Ş, ALTINTEPE L (2013). Gabapentin toxicity in patients with chronic kidney disease; series of our cases. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 22(3), 297 - 299.
Chicago Karagöz Ali,GÜNEY IBRAHIM,YAZICI Raziye,ARSLAN Şevket,ALTINTEPE Lütfullah Gabapentin toxicity in patients with chronic kidney disease; series of our cases. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 22, no.3 (2013): 297 - 299.
MLA Karagöz Ali,GÜNEY IBRAHIM,YAZICI Raziye,ARSLAN Şevket,ALTINTEPE Lütfullah Gabapentin toxicity in patients with chronic kidney disease; series of our cases. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.22, no.3, 2013, ss.297 - 299.
AMA Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L Gabapentin toxicity in patients with chronic kidney disease; series of our cases. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2013; 22(3): 297 - 299.
Vancouver Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L Gabapentin toxicity in patients with chronic kidney disease; series of our cases. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2013; 22(3): 297 - 299.
IEEE Karagöz A,GÜNEY I,YAZICI R,ARSLAN Ş,ALTINTEPE L "Gabapentin toxicity in patients with chronic kidney disease; series of our cases." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 22, ss.297 - 299, 2013.
ISNAD Karagöz, Ali vd. "Gabapentin toxicity in patients with chronic kidney disease; series of our cases". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 22/3 (2013), 297-299.