Fibromiyalji sendromunda uygulanan tedavi yöntemleri

SARAL, İlknur; SİNDEL, Dilşad; ESMAEİLZADEH, Sina

Fibromiyalji sendromunda uygulanan tedavi yöntemleri

Dilşad SİNDEL, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

İlknur SARAL, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Sina ESMAEİLZADEH (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye)

Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi

39 2

Yıl: 2012 Cilt: 58 Sayı: 2 Sayfa Aralığı: 136 - 142 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Fibromiyalji sendromunda uygulanan tedavi yöntemleri

Öz:

Fibromiyalji sendromu (FMS), genellikle allodini ve hiperaljezinin eşlik ettiği kronik yaygın ağrı ile karakterize multisistemik bir hastalıktır. Birçok hastada yorgunluk, tutukluk, uyku bozukluğu, depresyon ve anksiyete gibi komorbiditelerle ilişkili olduğundan sınıflandırılması ve tedavisi oldukça zordur. FMSde görülen ağrı, yorgunluk, depresyon, uyku bozukluğu ve bilişsel fonksiyon bozukluğu gibi çok sayıda belirti ve bulgu hastalarda fonksiyonel disabilite yaratarak günlük yaşam için gerekli aktiviteleri sürdürme kabiliyetini azaltarak yaşam kalitesini belirgin düzeyde bozmaktadır. Günümüze kadar yapılan çalışmalar, tedavide optimal yarar sağlayabilmenin ancak hastanın ağrı şiddetini, semptomlarını ve fonksiyonel durumunu göz önüne alan farmakolojik ve farmakolojik olmayan tedavi seçeneklerinin bir arada bulunduğu tedavi yaklaşımları ile olabileceğini göstermektedir. Bu derlemede amacımız, FMSde etkili olan farmakolojik ve farmakolojik olmayan tedavi yöntemlerini güncel literatürler eşliğinde gözden geçirmek ve tedavi yöntemleri ile ilgili kanıtları incelemektir. T

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Management approaches in fibromyalgia syndrome

Öz:

Fibromyalgia syndrome (FMS) is a multisystem disorder, characterized by widespread pain that is usually associated with hyperalgesia and allodynia. Comorbidities such as fatigue, stiffness, insomnia, depression and anxiety make its classification and treatment difficult. The confluence of pain and other symptoms and conditions such as fatigue, depression, sleep disturbance and cognitive dysfunction contribute to the reduced function and quality of life in patients with FMS. Clinical trials have shown that optimum benefit may be obtained only with therapeutic strategies including both pharmacological and non-pharmacological interventions taking into consideration pain severity, symptoms and functional status. The aim of this review was to summarize the current literature on pharmacological and non-pharmacological treatments of FMS as well as to evaluate the evidence of the value of the available treatment interventions.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Rooks DS. Fibromyalgia treatment update. Curr Opin Rheumatol 2007;19:111-17.
2. Cetin N. Factors affecting the quality of life in patients with fibromyalgia. Turk J Rheumatol 2009;24:77-81.
3. Lera S, Gelman SM, López MJ, Abenoza M, Zorrilla JG, Castro-Fornieles J, et al. Multidisciplinary treatment of fibromyalgia: does cognitive behavior therapy increase the response to treatment? J Psychosom Res 2009;67:433-41.
4. McBeth J, Jones K. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2007;21:403-25.
5. Ozkan O, Yildiz M, Koklukaya E. The correlation of laboratory tests and sympathetic skin response parameters by using artificial neural networks in fibromyalgia patients. J Med Syst 2011 Jan 5. [Epub ahead of print]
6. Solitar BM. Fibromyalgia: knowns, unknowns, and current treatment. Bull NYU Hosp Jt Dis 2010;68:157-61.
7. Forbes D, Chalmers A. Fibromyalgia: revisiting the literature. J Can Chiropr Assoc 2004;48:119-31.
8. Wolfe F, Hassett AL, Walitt B, Michaud K. Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res (Hoboken), 2011;63:94-101.
9. Recla JM. New and emerging therapeutic agents for the treatment of fibromyalgia: an update. J Pain Res 2010;3:89-103.
10. Jones GT, Nicholl BI, McBeth J, Davies KA, Morriss RK, Dickens C, et al. Role of road traffic accidents and other traumatic events in the onset of chronic widespread pain: Results from a population-based prospective study.Arthritis Care Res (Hoboken), 2011;63:696-701.
11. Dadabhoy D, Clauw DJ. Therapy insight: fibromyalgia-a different type of pain needing a different type of treatment. Nat Clin Pract Rheumatol 2006;2:364-72.
12. Gür A. Fibromiyaljide etiyopatogenez. Türk Fiz Tıp Rehab Derg 2008;54:4-11.
13. Sarzi-Puttini P, Buskila D, Carrabba M, Doria A, Atzeni F. Treatment strategy in fibromyalgia syndrome: where are we now? Semin Arthritis Rheum 2008;37:353-65.
14. Carville SF, Arendt-Nielsen S, Bliddal H, Blotman F, Branco JC, Buskila D, et al. EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 2008;67:536-41.
15. Häuser W, Thieme K, Turk DC. Guidelines on the management of fibromyalgia syndrome - a systematic review. Eur J Pain 2010;14:5-10.
16. Kasper S. The psychiatrist confronted with a fibromyalgia patient. Hum Psychopharmacol 2009;24:25-30.
17. Oh TH, Stueve MH, Hoskin TL, Luedtke CA, Vincent A, Moder KG, et al. Brief interdisciplinary treatment program for fibromyalgia: six to twelve months outcome. Am J Phys Med Rehabil 2010;89:115-24.
18. Ormseth MJ, Eyler AE, Hammonds CL, Boomershine CS. Milnacipran for the management of fibromyalgia syndrome. J Pain Res 2010;3:15-24.
19. Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004;292:2388-95.
20. Di Franco M, Iannuccelli C, Atzeni F, Cazzola M, Salaffi F, Valesini G, et al. Pharmacological treatment of fibromyalgia. Clin Exp Rheumatol 2010;28:110-16.
21. Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry 2009;31:206-19.
22. Goldenberg DL. Pharmacological treatment of fibromyalgia and other chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2007;21:499-511.
23. Ngian GS, Guymer EK, Littlejohn GO. The use of opioids in fibromyalgia. Int J Rheum Dis 2011;14:6-11.
24. Cuatrecasas G, Riudavets C, Güell MA, Nadal A. Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. A pilot study. BMC Musculoskelet Disord 2007;8:119.
25. M, Vernon H, Ko G, Lawson G, Perera J. Chiropractic management of fibromyalgia syndrome: a systematic review of the literature. J Manipulative Physiol Ther 2009;32:25-40.
26. Bonifazi M, Suman AL, Cambiaggi C, Felici A, Grasso G, Lodi L, et al. Changes in salivary cortisol and corticosteroid receptor-alpha mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia. Psychoneuroendocrinology 2006;31:1076-86.
27. Borg-Stein J. Treatment of fibromyalgia, myofascial pain and related disorders. Phys Med Rehabil Clin N Am 2006;17:491-510.
28. Smith HS, Harris R, Clauw D. Fibromyalgia: an afferent processing disorder leading to a complex pain generalized syndrome. Pain Physician 2011;14:217-45.
29. Kranzler JD, Gendreau RM. Role and rationale for the use of milnacipran in the management of fibromyalgia. Neuropsychiatr Dis Treat 2010;6:197-208.
30. Häuser W, Wolfe F, Tölle T, Uçeyler N, Sommer C. The role of antidepressants in the management of fibromyalgia syndrome: a systematic review and meta-analysis. CNS Drugs 2012;26:297-307.
31. Malemud CJ. Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome. Clin Exp Rheumatol 2009;27(Suppl 56):86-91.
32. Fitzcharles MA, Yunus MB. The clinical concept of fibromyalgia as a changing paradigm in the past 20 years. Pain Res Treat 2012;2012:184835. Epub 2011 Oct 29.
33. Derry S, Gill D, Phillips T, Moore RA. Milnacipran for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012 Mar 14;3:CD008244.
34. Arnold LM, Goldenberg DL, Stanford SB, Lalonde JK, Sandhu HS, Keck PE Jr, et al. Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial. Arthritis Rheum 2007;56:1336-44.
35. Straube S, Derry S, Moore RA, Paine J, McQuay HJ. Pregabalin in fibromyalgia-responder analysis from individual patient data. BMC Musculoskelet Disord 2010;11:150.
36. Siler AC, Gardner H, Yanit K, Cushman T, McDonagh M. Systematic review of the comparative effectiveness of antiepileptic drugs for fibromyalgia. J Pain 2011;12:407-15.
37. Tzellos TG, Toulis KA, Goulis DG, Papazisis G, Zampeli VA, Vakfari A, et al. Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis. J Clin Pharm Ther 2010;35:639-56.
38. Stacey BR, Emir B, Petersel D, Murphy K. Pregabalin in treatment- refractory fibromyalgia. Open Rheumatol J 2010;4:35-8.
39. Holman AJ, Myers RR. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum 2005;52:2495-505.
40. Russell IJ, Perkins AT, Michalek JE; Oxybate SXB-26 Fibromyalgia Syndrome Study Group. Sodium oxybate relieves pain and improves function in fibromyalgia syndrome: a randomized, double-blind, placebo-controlled, multicenter clinical trial. Arthritis Rheum 2009;60:299-309.
41. Cuatrecasas G, Alegre C, Fernandez-Solà J, Gonzalez MJ, Garcia-Fructuoso F, Poca-Dias V, et al. Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia. Pain 2012 Mar 30. [Epub ahead of print]
42. Moldofsky H, Inhaber NH, Guinta DR, Alvarez-Horine SB. Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study. J Rheumatol 2010;37:2156-66.
43. Rico-Villademoros F, Hidalgo J, Morillas-Arques P, Vilchez JS, Delgado- Rodriguez A, Calandre EP. An open-label study of levopromazine (methotrimeprazine) as an add-on therapy in fibromyalgia management. Clin Exp Rheumatol 2009;27:16-20.
44. lu M. Nonpharmacological and multidisciplinary treatment of fibromyalgia syndrome. Turkiye Klinikleri J Immunol Rheumatol-Special Topics 2009;2:59-66.
45. Hassett AL, Gevirtz RN. Nonpharmacologic treatment for fibromyalgia: patient education, cognitive-behavioral therapy, relaxation techniques, and complementary and alternative medicine. Rheum Dis Clin North Am 2009;35:393-407.
46. Mannerkorpi K, Henriksson C. Non-pharmacological treatment of chronic widespread musculoskeletal pain. Best Pract Res Clin Rheumatol 2007;21:513-34.
47. deHueck A. Effectiveness of exercise in management of fibromyalgia. Curr Opin Rheumatol 2004;16:138-42.
48. Sindel D, Ketenci A. Fibromyalji. Fibromyaljide diğer tedavi yaklaşımları. Gökçe Kutsal Y, editor. Modern Tıp Seminerleri 2001;16;45-56.
49. Vierck CJ. A mechanism-based approach to prevention of and therapy for fibromyalgia. Pain Res Treat 2012;2012:951354. Epub 2011 Oct 2.
50. Valim V, Oliveira L, Suda A, Silva L, de Assis M, Barros Neto T, et al. Aerobic fitness effects in fibromyalgia. J Rheumatol 2003;30:1060-9.
51. Sañudo B, Galiano D, Carrasco L, Blagojevic M, de Hoyo M, Saxton J. Aerobic exercise versus combined exercise therapy in women with fibromyalgia syndrome: a randomized controlled trial. Arch Phys Med Rehabil 2010;91:1838-43.
52. Assis MR, Silva LE, Alves AM, Pessanha AP, Valim V, Feldman D, et al. A randomized controlled trial of deep water running: clinical effectiveness of aquatic exercise to treat fibromyalgia. Arthritis Rheum 2006;55:57-65.
53. Valkeinen H, Häkkinen K, Pakarinen A, Hannonen P, Häkkinen A, Airaksinen O, et al. Muscle hypertrophy, strength development, and serum hormones during strength training in elderly women with fibromyalgia. Scand J Rheumatol 2005;34:309-14.
54. Ge HY, Wang Y, Danneskiold-Samsøe B, Graven-Nielsen T, Arendt-Nielsen L. The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points. J Pain 2010;11:644-51.
55. Kayiran S, Dursun E, Ermutlu N, Dursun N, Karamürsel S. Neurofeedback in fibromyalgia syndrome. Agri 2007;19:47-53.
56. Kayiran S, Dursun E, Dursun N, Ermutlu N, Karamursel S. Neurofeedback intervention in fibromyalgia syndrome; a randomized, controlled, rater blind clinical trial. Appl Psychophysiol Biofeedback 2010;35:293-302.
57. Assefi NP, Sherman KJ, Jacobsen C, Goldberg J, Smith WR, Buchwald D. A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med 2005;143:10-9.
58. Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc 2006;81:749-57.
59. van Koulil S, Effting M, Kraaimaat FW, van Lankveld W, van Helmond T, Cats H, et al. Cognitive-behavioural therapies and exercise programmes for patients with fibromyalgia: state of the art and future directions. Ann Rheum Dis 2007;66:571-81.
60. Burckhardt CS. Educating patients: self-management approaches. Disabil Rehabil 2005;27:703-9.
61. Rooks DS, Gautam S, Romeling M, Cross ML, Stratigakis D, Evans B, et al. Group exercise, education, and combination self-management in women with fibromyalgia: a randomized trial. Arch Intern Med 2007;167:2192-200.
62. Bennett R, Nelson D. Cognitive behavioral therapy for fibromyalgia. Nat Clin Pract Rheumatol 2006;2:416-24.
63. Lawson K. Treatment options and patient perspectives in the management of fibromyalgia: future trends. Neuropsychiatr Dis Treat 2008;4:1059-71.
64. Williams DA, Clauw DJ. Understanding fibromyalgia: lessons from the broader pain research community. J Pain 2009;10:777-91.
65. Thieme K, Gromnica-Ihle E, Flor H. Operant behavioral treatment of fibromyalgia: a controlled study. Arthritis Rheum 2003;49:314-20.
66. Scascighini L, Toma V, Dober-Spielmann S, Sprott H. Multidisciplinary treatment for chronic pain: a systematic review of interventions and outcomes. Rheumatology (Oxford) 2008;47:670-8.
67. Häuser W, Bernardy K, Arnold B, Offenbächer M, Schiltenwolf M. Efficacy of multicomponent treatment in fibromyalgia syndrome: a meta-analysis of randomized controlled clinical trials. Arthritis Rheum 2009;61:216-24.
68. Saral I, Sindel D, Berk OS, Esmaeilzadeh S. The effectiveness of long-term and short-term interdisciplinary treatment approaches in female patients with fibromyalgia. Arthritis Rheum 2011;22:364-5 (P930).
69. van Koulil S, Kraaimaat FW, van Lankveld W, van Riel PL, Evers AW. A patient's perspective on multidisciplinary treatment gain for fibromyalgia: an indicator for pre-post treatment effects? Arthritis Rheum 2009;61:1626-32.
70. Edwards RR, Calahan C, Mensing G, Smith M, Haythornthwaite JA. Pain, catastrophizing, and depression in the rheumatic diseases. Nat Rev Rheumatol 2011;7:216-24.

APA	SİNDEL D, SARAL İ, ESMAEİLZADEH S (2012). Fibromiyalji sendromunda uygulanan tedavi yöntemleri. , 136 - 142.
Chicago	SİNDEL Dilşad,SARAL İlknur,ESMAEİLZADEH Sina Fibromiyalji sendromunda uygulanan tedavi yöntemleri. (2012): 136 - 142.
MLA	SİNDEL Dilşad,SARAL İlknur,ESMAEİLZADEH Sina Fibromiyalji sendromunda uygulanan tedavi yöntemleri. , 2012, ss.136 - 142.
AMA	SİNDEL D,SARAL İ,ESMAEİLZADEH S Fibromiyalji sendromunda uygulanan tedavi yöntemleri. . 2012; 136 - 142.
Vancouver	SİNDEL D,SARAL İ,ESMAEİLZADEH S Fibromiyalji sendromunda uygulanan tedavi yöntemleri. . 2012; 136 - 142.
IEEE	SİNDEL D,SARAL İ,ESMAEİLZADEH S "Fibromiyalji sendromunda uygulanan tedavi yöntemleri." , ss.136 - 142, 2012.
ISNAD	SİNDEL, Dilşad vd. "Fibromiyalji sendromunda uygulanan tedavi yöntemleri". (2012), 136-142.

APA	SİNDEL D, SARAL İ, ESMAEİLZADEH S (2012). Fibromiyalji sendromunda uygulanan tedavi yöntemleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 58(2), 136 - 142.
Chicago	SİNDEL Dilşad,SARAL İlknur,ESMAEİLZADEH Sina Fibromiyalji sendromunda uygulanan tedavi yöntemleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 58, no.2 (2012): 136 - 142.
MLA	SİNDEL Dilşad,SARAL İlknur,ESMAEİLZADEH Sina Fibromiyalji sendromunda uygulanan tedavi yöntemleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.58, no.2, 2012, ss.136 - 142.
AMA	SİNDEL D,SARAL İ,ESMAEİLZADEH S Fibromiyalji sendromunda uygulanan tedavi yöntemleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2012; 58(2): 136 - 142.
Vancouver	SİNDEL D,SARAL İ,ESMAEİLZADEH S Fibromiyalji sendromunda uygulanan tedavi yöntemleri. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2012; 58(2): 136 - 142.
IEEE	SİNDEL D,SARAL İ,ESMAEİLZADEH S "Fibromiyalji sendromunda uygulanan tedavi yöntemleri." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 58, ss.136 - 142, 2012.
ISNAD	SİNDEL, Dilşad vd. "Fibromiyalji sendromunda uygulanan tedavi yöntemleri". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 58/2 (2012), 136-142.