Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease

Yıl: 2012 Cilt: 40 Sayı: 3 Sayfa Aralığı: 223 - 228 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease

Öz:
Amaç: Yapılan çeşitli çalışmalarda, enflamasyonun ateroskleroz gelişiminde önemli bir rol aldığı ve enflamatuvar sürecin aynı zamanda koroner arter kalsifikasyonu (KAK) ile de ilişkili olabileceği gösterilmiştir. Bu çalışmanın temel amacı, belirgin kardiyovasküler hastalığı olmayan hastalarda lökosit sayısı ile KAK arasındaki ilişkiyi ve artmış lökosit sayısının subklinik aterosklerozun bir göstergesi olup olamayacağını araştırmaktır. Çalışma planı: Kardiyovasküler hastalığı olmayan ardışık 284 hasta (156 erkek, 128 kadın) çalışmaya alındı. KAK bilgisayarlı kardiyak tomografi ile değerlendirilidi. Lökosit sayısı rutin kan incelemesi yoluyla ölçüldü. Bulgular: Lökosit sayısı, KAK olanlarda olmayanlara göre anlamlı olarak yüksek bulundu (7.87±1.85 ve 6.01±1.84; p<0.001). Lojistik regresyon analizde lökosit sayısı (odds oranı [OO]: 1.7, %95 güven aralığı [GA]: 1.3-2.1), sigara içimi (OO: 2.4, %95 GA: 1.2-4.6) ve yaş (OO: 1.2, %95 GA: 1.1-2.3) KAKnin bağımsız öngördürücüleri olarak bulundu. Lökosit sayısı ile KAK arasında anlamlı ilişki saptandı (r=0.57, p<0.001). Sonuç: Lökosit KAK gelişiminde önemli rol oynayabilir ve artmış lökosit sayısı subklinik aterosklerozun göstergesi olabilir.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Bilinen kardiyovasküler hastalığı olmayanlarda artmış lökosit sayısı koroner arter kalsifikasyonu için belirleyici olabilir

Öz:
Objectives: Several studies have demonstrated that inflam- mation plays a major role in the development of atherosclero- sis and that the inflammatory process might also be involved in coronary artery calcification (CAC). The main purpose of this study was to investigate the relation between leucocyte count and CAC and to determine whether a higher leucocyte count could indicate subclinical atherosclerosis in patients without overt cardiovascular disease. Study design: A total of 284 consecutive patients (156 men, 128 women) without established cardiovascular disease were enrolled. CAC was measured using cardiac computed tomography. Leucocyte count was measured via routine blood examination. Results: Patients with CAC had higher leucocyte counts compared to those without calcification (7.87±1.85 vs. 6.01±1.84; p<0.001). Logistic regression analysis identified the following as independent predictors of CAC: leucocyte count (odds ratio [OR]: 1.7, 95% confidence interval [CI]: 1.3- 2.1), smoking (OR: 2.4, 95% CI: 1.2-4.6) and age (OR: 1.2, 95% CI: 1.1-2.3). There was also a significant correlation be- tween CAC and leucocyte count (r=0.57, p<0.001). Conclusion: We demonstrated that leucocytes may play an im- portant role in the evolution of CAC and may be used in the de- tection of subclinical atherosclerosis in asymptomatic subjects.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA KORKMAZ L, KUL S, KORKMAZ A, AKYÜZ A, AĞAÇ M, Erkan H, ACAR Z, adar a, ERKUŞ M, ÇELİK Ş (2012). Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. , 223 - 228.
Chicago KORKMAZ Levent,KUL Selim,KORKMAZ Ayça ATA,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,Erkan Hakan,ACAR Zeydin,adar adem,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. (2012): 223 - 228.
MLA KORKMAZ Levent,KUL Selim,KORKMAZ Ayça ATA,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,Erkan Hakan,ACAR Zeydin,adar adem,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. , 2012, ss.223 - 228.
AMA KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. . 2012; 223 - 228.
Vancouver KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. . 2012; 223 - 228.
IEEE KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş "Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease." , ss.223 - 228, 2012.
ISNAD KORKMAZ, Levent vd. "Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease". (2012), 223-228.
APA KORKMAZ L, KUL S, KORKMAZ A, AKYÜZ A, AĞAÇ M, Erkan H, ACAR Z, adar a, ERKUŞ M, ÇELİK Ş (2012). Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. Türk Kardiyoloji Derneği Arşivi, 40(3), 223 - 228.
Chicago KORKMAZ Levent,KUL Selim,KORKMAZ Ayça ATA,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,Erkan Hakan,ACAR Zeydin,adar adem,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. Türk Kardiyoloji Derneği Arşivi 40, no.3 (2012): 223 - 228.
MLA KORKMAZ Levent,KUL Selim,KORKMAZ Ayça ATA,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,Erkan Hakan,ACAR Zeydin,adar adem,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. Türk Kardiyoloji Derneği Arşivi, vol.40, no.3, 2012, ss.223 - 228.
AMA KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. Türk Kardiyoloji Derneği Arşivi. 2012; 40(3): 223 - 228.
Vancouver KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease. Türk Kardiyoloji Derneği Arşivi. 2012; 40(3): 223 - 228.
IEEE KORKMAZ L,KUL S,KORKMAZ A,AKYÜZ A,AĞAÇ M,Erkan H,ACAR Z,adar a,ERKUŞ M,ÇELİK Ş "Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease." Türk Kardiyoloji Derneği Arşivi, 40, ss.223 - 228, 2012.
ISNAD KORKMAZ, Levent vd. "Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease". Türk Kardiyoloji Derneği Arşivi 40/3 (2012), 223-228.