The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography

TEKÇE, Hikmet; TANRISEV, Mehmet; KURTULMUŞ, Yusuf; ŞAHİN, SEVNAZ; ALP, ALPER; ÖZDOĞAN, Ömer; GÜLOĞLU ÇOLAK, Canan; Çolak, Hülya

The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography

Canan GÜLOĞLU ÇOLAK, (SB İzmir Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye)

Alper ALP, (SB İzmir Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye)

SEVNAZ ŞAHİN, (Ege Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, İzmir, Türkiye)

Ömer ÖZDOĞAN, (İzmir Tepecik Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İzmir, Türkiye)

Yusuf KURTULMUŞ, (İzmir Tepecik Eğitim ve Araştırma Hastanesi, Biyokimya Kliniği, İzmir, Türkiye)

Hülya ÇOLAK, (SB İzmir Tepecik Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İzmir, Türkiye)

Mehmet TANRISEV, (SB İzmir Tepecik Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İzmir, Türkiye)

Hikmet TEKÇE (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Nefroloji Anabilim Dalı, Bolu, Türkiye)

Türk Nefroloji Diyaliz ve Transplantasyon Dergisi

5 0

Yıl: 2014 Cilt: 23 Sayı: 3 Sayfa Aralığı: 223 - 228 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography

Öz:

AMAÇ: Kontrast madde nefropatisi; diğer nedenler ekarte edildikten sonra kontrast ajanın uygulan- masını takiben gelişen bir akut böbrek hasarı tablosudur. Çalışmamızda, klinik pratikte sıklığı giderek artan ve kardiyak kateterizasyon yapılan olgularda önemli bir akut böbrek yetmezliği sebebi olan kont- rast madde nefropatisinin erken tanısında üriner NGAL(neutrophil gelatinase associated lipocalin)in yerini saptamayı amaçladık. GEREÇ ve YÖNTEMLER: Çalışmamıza, 1 Ocak 2011 ve 1 Mart 2011 tarihleri arasında elektif koroner anjiyografi uygulanan 100 olgu dahil edildi. Hastaların üriner NGAL seviyeleri için idrar örnekleri koroner anjiyografi yapıldıktan en geç 4 saat içinde alındı. BULGULAR: Koroner anjiyografiyi izleyen 48. saatte 8 hastanın kreatinin seviyeleri en az %25 artmıştı ve kontrast madde nefropatisi(KMN) tanısı konuldu. Bu 8 hastanın tamamında üriner NGAL değerleri kabul edilebilir sınır olan 100 ng/ml üzerindeydi.KMN gelişen hastaların 6sı kadın ve 2si erkekti. Tüm hastalarda hipertansiyon veya eşlik eden bir diğer kronik hastalık mevcuttu. SONUÇ: Anjiyografi sonrası KMN tanısı konvansiyonel metodla işlemden 48 saat sonra kreatinin düzeyi bakılarak konulabilmektedir fakat üriner NGAL düzeyi bakılması tanı ve tedaviyi hızlandırabilir ve hastanede kalma süresini kısaltabilir.

Anahtar Kelime:

Konular: Cerrahi

Koroner anjiyografi yapılan hastalarda kontrast madde nefropatisini saptamada nötrofil jelatinaz ilişkili lipokalinin yeri

Öz:

OBJECTIVE: Contrast-induced nephropathy (CIN) is the acute kidney injury developing following he administration of contrast agent after all other reasons are excluded. We aimed to determine the ole of NGAL in the urine for early diagnosis of contrast-induced nephropathy, as the disorder is an mportant reason of acute renal failure in cases subject to cardiac catheterization clinical practice, and he frequency is increasing. MATERIAL and METHODS: One hundred cases undergoing elective coronary angiography between he dates of January 1st 2011 and March 1st 2011 were included in the study. Urine samples of the patients were taken maximum 4 hours after the coronary angiography to check the urinary NGAL level. RESULTS: The creatinine level had increased 25% in 8 patients at the 48th hour following angiography and this was accepted as CIN. Using a cutoff value of 100 ng/ml, urinary NGAL levels were found to elevated in these 8 patients, consisting of 6 females and 2 males. All them had hypertension (HT) by tself or with other accompanying diseases. CONCLUSION: The CIN diagnosis can be made with the conventional method of measuring the level of creatinine in the blood 48 hours after surgery but using the urinary NGAL method can fasten the diagnosis and treatment and also can shorten hospital stays.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜLOĞLU ÇOLAK C, ALP A, ŞAHİN S, ÖZDOĞAN Ö, KURTULMUŞ Y, Çolak H, TANRISEV M, TEKÇE H (2014). The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. , 223 - 228.
Chicago	GÜLOĞLU ÇOLAK Canan,ALP ALPER,ŞAHİN SEVNAZ,ÖZDOĞAN Ömer,KURTULMUŞ Yusuf,Çolak Hülya,TANRISEV Mehmet,TEKÇE Hikmet The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. (2014): 223 - 228.
MLA	GÜLOĞLU ÇOLAK Canan,ALP ALPER,ŞAHİN SEVNAZ,ÖZDOĞAN Ömer,KURTULMUŞ Yusuf,Çolak Hülya,TANRISEV Mehmet,TEKÇE Hikmet The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. , 2014, ss.223 - 228.
AMA	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. . 2014; 223 - 228.
Vancouver	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. . 2014; 223 - 228.
IEEE	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H "The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography." , ss.223 - 228, 2014.
ISNAD	GÜLOĞLU ÇOLAK, Canan vd. "The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography". (2014), 223-228.

APA	GÜLOĞLU ÇOLAK C, ALP A, ŞAHİN S, ÖZDOĞAN Ö, KURTULMUŞ Y, Çolak H, TANRISEV M, TEKÇE H (2014). The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 23(3), 223 - 228.
Chicago	GÜLOĞLU ÇOLAK Canan,ALP ALPER,ŞAHİN SEVNAZ,ÖZDOĞAN Ömer,KURTULMUŞ Yusuf,Çolak Hülya,TANRISEV Mehmet,TEKÇE Hikmet The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 23, no.3 (2014): 223 - 228.
MLA	GÜLOĞLU ÇOLAK Canan,ALP ALPER,ŞAHİN SEVNAZ,ÖZDOĞAN Ömer,KURTULMUŞ Yusuf,Çolak Hülya,TANRISEV Mehmet,TEKÇE Hikmet The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.23, no.3, 2014, ss.223 - 228.
AMA	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2014; 23(3): 223 - 228.
Vancouver	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2014; 23(3): 223 - 228.
IEEE	GÜLOĞLU ÇOLAK C,ALP A,ŞAHİN S,ÖZDOĞAN Ö,KURTULMUŞ Y,Çolak H,TANRISEV M,TEKÇE H "The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 23, ss.223 - 228, 2014.
ISNAD	GÜLOĞLU ÇOLAK, Canan vd. "The role of neutrophil gelatinase-associated lipocalin (ngal) in the determination of contrast-ınduced nephropathy in patients undergoing coronary angiography". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 23/3 (2014), 223-228.