Objective: We aimed to present patients with dialysis-dependent chronic kidney failure who underwent open heart surgery. Materials and Methods: Sixteen patients with dialysis-dependent end-stage chronic kidney failure (7 males, 9 females; mean age 62±11; range 30-75) were involved in the study. Coronary artery bypass surgery was performed for 12 patients, 2 patients underwent both coronary artery bypass surgery and aortic valve replacement, 1 underwent both ascending aorta and aortic valve replacement, and right atrial myxoma resection was performed for 1 patient. The preoperative, intraoperative, and postopera- tive data were analyzed retrospectively. Results: Fourteen patients underwent coronary artery bypass surgery, and the mean distal bypass was found to be 3.07±0.9. The mean cross-clamp time was 50±27 minutes, and the total cardiovascular bypass duration was 87±40 minutes. None of the patients needed revision. The mean drainage volume was 500±150 milliliters. Atrial fibrillation occurred in 4 patients (25%), and all of them converted to sinus rhythm through medical treatment. One patient died on the second postoperative day because of fatal arrhythmia that occurred after dialysis, and 1 patient died because of low cardiac output during the intensive care follow-up. The mortality rate was 12.5%. The mean intensive care unit hospitalization time was 52±4 hours, and the total hospitalization time was 7±2 days. Conclusion: Open heart surgery can be performed with acceptable mortality and morbidity rates for patients having dialysis- dependent chronic kidney failure.