Aim: In this study, the relationship between the level of prostaglandin F2&#945; and ovine sarcosproridiosis infection were investigated for abortion mechanism.Materials and Methods: Materials were collected at slaughterhouse of Aydın region. In order to identification of parasite, macroscopical and microscopical cysts were used for S. gigantea and S. arieticanis or S. tenella by the PCR and Modified Trypcine Technique. Also in order to determination of the level of prostaglandin F2&#945; in blood samples were used the methods of enzimmunoassay using a commercial kit (EIA).Results: A total number of 114 sheep oesophageal muscle were found in 9 (7.89%) to be infected with Sarcocystis macroscopic cysts. Examinations of a total number of 114 sheep were found in 58 (55.23%) of the sheep with microscopic cyst. These microscopic cyst species corresponding values were as follows: 32 (30.47%), 17 (16.19%) and 9 (8.57%) for S. tenella, S. gigantae and S. arieticanis, respectively. In addition a total number of 114 sheep blood examinations were determined in 9 (7.89%) samples at 300 and 402 pg/mL, 47 (41.22%) samples at 200 to 300 pg/mL and 58 (50.87%) samples at 53-200 pg/mL ranging between the levels of prostaglandin F2&#945;. The differences between groups were found statistically significant (P<0.001).Conclusions: In this study were detected in different values of the level of prostaglandin F2&#945;, when the relationship between the level of prostaglandin F2&#945; and macrocyst and microcyst in the oesophageal muscle of sheep were assessed. In conclusion, the aborts formation in Sarcosporidiosis infection may be associated with prostaglandin F2&#945; identified.