Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Mukaddes EŞREFOĞLU, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)
Ayşin AKINCI, (Doğu Fertil Tüp Bebek Merkezi, Malatya, Türkiye)
Hülya ELBE, (İnönü Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Malatya, Türkiye)
Elif TAŞLIDERE, (İnönü Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Malatya, Türkiye)
Aslı ÇETİN, (İnönü Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Malatya, Türkiye)
Burhan ATEŞ (İnönü Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)
Turkish Journal of Biology
7 0
Yıl: 2014 Cilt: 38 Sayı: 4 Sayfa Aralığı: 493 - 501 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats

Öz:
In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.
Anahtar Kelime:

Konular: Biyoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Esrefoglu M, AKINCI A, Elbe H, TAŞLIDERE E, ÇETİN A, Ates B (2014). Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. , 493 - 501.
Chicago Esrefoglu Mukaddes,AKINCI Ayşin,Elbe Hulya,TAŞLIDERE Elif,ÇETİN Aslı,Ates Burhan Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. (2014): 493 - 501.
MLA Esrefoglu Mukaddes,AKINCI Ayşin,Elbe Hulya,TAŞLIDERE Elif,ÇETİN Aslı,Ates Burhan Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. , 2014, ss.493 - 501.
AMA Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. . 2014; 493 - 501.
Vancouver Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. . 2014; 493 - 501.
IEEE Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B "Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats." , ss.493 - 501, 2014.
ISNAD Esrefoglu, Mukaddes vd. "Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats". (2014), 493-501.
APA Esrefoglu M, AKINCI A, Elbe H, TAŞLIDERE E, ÇETİN A, Ates B (2014). Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology, 38(4), 493 - 501.
Chicago Esrefoglu Mukaddes,AKINCI Ayşin,Elbe Hulya,TAŞLIDERE Elif,ÇETİN Aslı,Ates Burhan Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology 38, no.4 (2014): 493 - 501.
MLA Esrefoglu Mukaddes,AKINCI Ayşin,Elbe Hulya,TAŞLIDERE Elif,ÇETİN Aslı,Ates Burhan Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology, vol.38, no.4, 2014, ss.493 - 501.
AMA Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology. 2014; 38(4): 493 - 501.
Vancouver Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology. 2014; 38(4): 493 - 501.
IEEE Esrefoglu M,AKINCI A,Elbe H,TAŞLIDERE E,ÇETİN A,Ates B "Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats." Turkish Journal of Biology, 38, ss.493 - 501, 2014.
ISNAD Esrefoglu, Mukaddes vd. "Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats". Turkish Journal of Biology 38/4 (2014), 493-501.
Sayfa Oluşturulma Tarihi
22-04-2024 20:23

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