Yıl: 2013 Cilt: 23 Sayı: 6 Sayfa Aralığı: 736 - 741 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery

Öz:
AMAÇ: Endoskopik endonazal trassfenoidal cerrahi (EETC) sonrasında gelişen postoperatif beyin omurilik sıvısı (BOS) kaçağı bu prosedürünmorbidite ve mortalitesini arttıran bir faktördür. Bu prospektif çalışma postoperatif BOS kaçağının ve buna bağlı komplikasyonlarınengellenmesi amacıyla otolog fibrin yapıştırıcı kullanımının ilk örneğidir.YÖNTEM ve GEREÇLER: Ekim 2010 ile Haziran 2012 arasında endoskopik endonazal transsfenoidal yaklaşım ile ameliyat edilen 200 olguretrospektif olarak değerlendirildi ve çalışmaya dahil edildi. Bunlar arasından bazal sisternler veya ventriküller ile ilişkisi olan geniş diafragmasella defekti veya geniş kafa tabanı defekti bulunan toplam 55 hasta seçildi. Hastalar genişletilmiş veya klasik endoskopik endonazaltranssfenoidal yaklaşım ile opere edildi. Kafa tabanı tamiri tüm olgularda çok katmanlı tamir yöntemi ile otolog fibrin yapıştırıcı kullanılarakgerçekleştirildi. EETCnin bir komplikasyonu olan BOS kaçağının insidansı analiz edildi. BULGULAR: Hastaların yaş dağılımı 20 ile 83 (ortalama 49.3) arasında idi. Bunlardan 25i (%46) erkek, 30u (%54) kadındı. Tüm hastalardasuprasellar veya parasellar uzanım gösteren tümör bulunmaktaydı. İki hastada (%3.6) postoperatif BOS kaçağı saptandı. Otolog fibrinyapıştırıcıya bağlı herhangi bir komplikasyon veya allerjik reaksiyona rastlanmadı. SONUÇ: Çok katmanlı tamir ile birlikte otolog fibrin yapıştıcı kullanımının, EETC sonrası gelişebilecek BOS kaçağının engellenmesinde güvenlive etkin bir teknik olduğunu düşünmekteyiz.
Anahtar Kelime:

Konular: Cerrahi

Endoskopik Endonazal Transsfenoidal Cerrahi Sırasında Oluşan geniş Kafa Tabanı defektine Bağlı Beyin Omurilik Sıvısı Kaçağı Tamirinde Otolog fibrin Yapıştırıcı Kullanımı

Öz:
AIM: Postoperative cerebrospinal fluid (CSF) leak following endoscopic endonasal transsphenoidal surgery (EETS) is associated with increasedmorbidity and mortality. This prospective study is the first evaluation of using autologous fibrin sealant for preventing postoperative CSF leakand related complications. MATERIAL and METHODS: 200 endoscopic endonasal transsphenoidal approaches were included in the study and reviewed retrospectivelyfrom September 2010 to June 2012. A total of 55 patients who have large skull base and diafragma sella defects, connected with basal cisternsor ventricles, were chosen for the study. The patients were operated via extended or classical endoscopic endonasal transsphenoidal approach.The skull base has been repaired using AFS combined with multilayer reconstruction in all cases. The incidence of CSF leak as a complicationof EETS was analyzed.results: The ages of the patients ranged from 20 to 83 years (mean 49.3 years). There were 25 (46%) male patients and 30 (54%) females.All patients had tumors with suprasellar or parasellar extension. Postoperative CSF leak was determined in 2 patients (3.6%). There were nocomplications and allergic reactions associated with the use of AFS.CONCLUSION: Using of AFS combined with multilayer reconstruction technique is a safe and effective method to prevent CSF leak in largedefects following EETS.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA YILDIRIM A, DURSUN E, ÖZDÖL Ç, DIVANLIOGLU D, NACAR O, Karakoyun D, Eryılmaz A, BELEN A (2013). using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. , 736 - 741.
Chicago YILDIRIM Ali Erdem,DURSUN Engin,ÖZDÖL Çağatay,DIVANLIOGLU Denizhan,NACAR Osman Arıkan,Karakoyun Durmuş Oğuz,Eryılmaz Adil,BELEN Ahmed Deniz using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. (2013): 736 - 741.
MLA YILDIRIM Ali Erdem,DURSUN Engin,ÖZDÖL Çağatay,DIVANLIOGLU Denizhan,NACAR Osman Arıkan,Karakoyun Durmuş Oğuz,Eryılmaz Adil,BELEN Ahmed Deniz using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. , 2013, ss.736 - 741.
AMA YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. . 2013; 736 - 741.
Vancouver YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. . 2013; 736 - 741.
IEEE YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A "using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery." , ss.736 - 741, 2013.
ISNAD YILDIRIM, Ali Erdem vd. "using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery". (2013), 736-741.
APA YILDIRIM A, DURSUN E, ÖZDÖL Ç, DIVANLIOGLU D, NACAR O, Karakoyun D, Eryılmaz A, BELEN A (2013). using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. Turkish Neurosurgery, 23(6), 736 - 741.
Chicago YILDIRIM Ali Erdem,DURSUN Engin,ÖZDÖL Çağatay,DIVANLIOGLU Denizhan,NACAR Osman Arıkan,Karakoyun Durmuş Oğuz,Eryılmaz Adil,BELEN Ahmed Deniz using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. Turkish Neurosurgery 23, no.6 (2013): 736 - 741.
MLA YILDIRIM Ali Erdem,DURSUN Engin,ÖZDÖL Çağatay,DIVANLIOGLU Denizhan,NACAR Osman Arıkan,Karakoyun Durmuş Oğuz,Eryılmaz Adil,BELEN Ahmed Deniz using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. Turkish Neurosurgery, vol.23, no.6, 2013, ss.736 - 741.
AMA YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. Turkish Neurosurgery. 2013; 23(6): 736 - 741.
Vancouver YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery. Turkish Neurosurgery. 2013; 23(6): 736 - 741.
IEEE YILDIRIM A,DURSUN E,ÖZDÖL Ç,DIVANLIOGLU D,NACAR O,Karakoyun D,Eryılmaz A,BELEN A "using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery." Turkish Neurosurgery, 23, ss.736 - 741, 2013.
ISNAD YILDIRIM, Ali Erdem vd. "using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid leak with large Skull Base Defect Following Endoscopic Endonasal transsphenoidal Surgery". Turkish Neurosurgery 23/6 (2013), 736-741.