Yıl: 2014 Cilt: 24 Sayı: 3 Sayfa Aralığı: 391 - 397 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage

Öz:
AMAÇ: Anevrizmal subaraknoid kanamalı hastalarda (SAK), postoperatif iskemik durumlar ve prognozla ilişkili olarak beyin omurilik sıvısı (BOS)sistatin C (SC) düzeylerindeki değişiklikleri araştırmaktır.YÖNTEM ve GEREÇLER: Çalışma grubu, mikrocerrahi olarak klibe edilmiş intrakranial anevrizmalı (İA) 40 hasta ile 22 kontrol BOS örneğiniiçermekteydi. Hastalarda BOS örnekleri lomber intratekal katater yoluyla ameliyatın başında, hemen sonrasında (erken postoperatif) veameliyat sonrası birinci günde (geç postoperatif) sağlandı.BuLGuLAR: Üç dönemdeki CC düzeyleri de Hunt-Hess skoru 4, 5 hastalarda, 1, 2 ve 3 olanlara göre anlamlı olarak yüksekti. Postoperatifbirinci gün SC düzeyleri ile kontrol grubu arasındaki fark istatistiksel olarak anlamlı idi. Fokal serebral iskemi gelişen hastalarda erken ve geçpostoperatif dönemdeki SC düzeyleri, iskemi gelişmeyen gruba göre anlamlı olarak yüksekti. Ayrıca, kötü prognoz gösteren (GOS 1, 2, 3)hastalar, iyi prognoz gösterenlere göre (GOS 4, 5) her üç dönemde de anlamlı olarak yüksek SC konsantrasyonlarına sahipti. SONUÇ: Anevrizmal SAKlı hastalarda artmış BOS SC düzeyleri, kanamanın ciddiyeti, intraoperatif iskemik olaylar ve kötü prognozla ilişkiligörünmektedir.
Anahtar Kelime:

Konular: Cerrahi

Anevrizmal Subaraknoid Kanama Tedavisi Sonrası Beyin Omurilik Sıvısı Sistatin C Düzeyleri

Öz:
AIM: To investigate the changes of cerebrospinal fluid (CSF) cystatin C (CC) levels associated with the postoperative ischemic conditions andprognostic outcome in patients with aneurysmal subarachnoid hemorrhage (SAH).MATERIAL and METHODS: The study group consisted of 40 patients with microsurgically clipped intracranial aneurysms (IA s) and 22 controlCSF samples. In patients, CSF samples were taken from the lumbar intrathecal catheter for CC measurement, at the beginning of operation,immediately after the operation (early postoperative), and the first postoperative day (late postoperative).RESULTS: CC levels in three periods were significantly higher in patients with Hunt-Hess scores of 4, 5 than 1, 2, 3. There was a significantdifference between the CC concentrations on the first postoperative day and controls. In patients who developed focal cerebral ischemia,CC levels at early and late postoperative periods were significantly higher than the group without ischemia. In addition, patients with poorprognostic outcome (GOS score of 1, 2, 3) had significantly higher levels of CC in all three periods than that of patients with good outcome(GOS score of 4, 5). CONCLUSION: The raised CSF CC concentrations appear to be associated with the severity of bleeding, intraoperative ischemic events andpoor prognostic outcome in patients with aneurysmal SAH.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÖKSU E, GOKSU E, KARSLI B, AKYÜZ M, Akbas H, ÜNAL A, Boztug N, TUNCER R (2014). Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. , 391 - 397.
Chicago GÖKSU Ethem,GOKSU Ebru,KARSLI Bilge,AKYÜZ Mahmut,Akbas Halide,ÜNAL Ali,Boztug Neval,TUNCER Recai Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. (2014): 391 - 397.
MLA GÖKSU Ethem,GOKSU Ebru,KARSLI Bilge,AKYÜZ Mahmut,Akbas Halide,ÜNAL Ali,Boztug Neval,TUNCER Recai Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. , 2014, ss.391 - 397.
AMA GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. . 2014; 391 - 397.
Vancouver GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. . 2014; 391 - 397.
IEEE GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R "Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage." , ss.391 - 397, 2014.
ISNAD GÖKSU, Ethem vd. "Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage". (2014), 391-397.
APA GÖKSU E, GOKSU E, KARSLI B, AKYÜZ M, Akbas H, ÜNAL A, Boztug N, TUNCER R (2014). Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. Turkish Neurosurgery, 24(3), 391 - 397.
Chicago GÖKSU Ethem,GOKSU Ebru,KARSLI Bilge,AKYÜZ Mahmut,Akbas Halide,ÜNAL Ali,Boztug Neval,TUNCER Recai Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. Turkish Neurosurgery 24, no.3 (2014): 391 - 397.
MLA GÖKSU Ethem,GOKSU Ebru,KARSLI Bilge,AKYÜZ Mahmut,Akbas Halide,ÜNAL Ali,Boztug Neval,TUNCER Recai Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. Turkish Neurosurgery, vol.24, no.3, 2014, ss.391 - 397.
AMA GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. Turkish Neurosurgery. 2014; 24(3): 391 - 397.
Vancouver GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage. Turkish Neurosurgery. 2014; 24(3): 391 - 397.
IEEE GÖKSU E,GOKSU E,KARSLI B,AKYÜZ M,Akbas H,ÜNAL A,Boztug N,TUNCER R "Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage." Turkish Neurosurgery, 24, ss.391 - 397, 2014.
ISNAD GÖKSU, Ethem vd. "Cerebrospinal Fluid Cystatin C levels Following treatment for Aneurysmal Subarachnoid Hemorrhage". Turkish Neurosurgery 24/3 (2014), 391-397.