Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet

UZ, Efkan; SAVAS, Hasan Basri; Demir Özer, Ezgi; ÖNER, Zübeyde; Şanlıdere Aloğlu, Hatice

Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet

HATİCE ŞANLIDERE ALOĞLU, (Kırklareli Üniversitesi, Mühendislik Fakültesi, Gıda Mühendisliği Bölümü, Kırklareli, Türkiye)

EZGİ DEMİR ÖZER, (Niğde Üniversitesi, Mühendislik Fakültesi, Gıda Mühendilsiği Bölümü, Niğde, Türkiye)

Zübeyde ÖNER, (Süleyman Demirel Üniversitesi, Mühendislik Fakültesi, Gıda Mühendisliği Bölümü, Isparta, Türkiye)

Hasan Basri SAVAŞ, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Isparta, Türkiye)

Efkan UZ (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Isparta, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2015 Cilt: 21 Sayı: 5 Sayfa Aralığı: 685 - 689 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet

Öz:

Yüksek kolesterol asimilasyon yeteneğine sahip probiyotik maya Cryptococcus humicola M5-2 suşu, geleneksel olarak üretilmiş birpeynirden izole edilmiş ve in vivo ortamda incelenmiştir. Çalışmada, C. humicola M5-2 suşunun in vivo ortamda kolesterolü asimileetme yeteneği incelenmiş ve kolesterolce zengin diyetle beslenen sıçanlarda bu suş ile beslemenin serum toplam kolesterol, HDL/LDLkolesterol ve trigliserit seviyelerine etkisi belirlenmiştir. C. humicola nın besiyeri içersindeki kolesterolü asimile etme oranı %73.33tür.Hayvanların beslenmesinde suş iki farklı dozda kullanılmıştır (yüksek ve düşük doz, sırasıyla %2 ve %0.1 liyofilize suş içermektedir).Deneme grupları karşılaştırıldığında, düşük doz besleme grubu daha olumlu sonuçlar göstermiştir. Serum analiz sonucuna göretrigliserit ve toplam kolesterol düzeyi sırasıyla %25 ve %1.34 oranında düşme göstermiştir. Özellikle trigliserit düzeyindeki düşme oranıçoğu in vivo çalışmada rastlanmamıştır. Elde edilen suşun fermente gıdalar ile beraber tüketiminin sağlık üzerine iyileştirici etkileryaratacağı düşünülmektedir.

Anahtar Kelime:

Konular: Veterinerlik

Probiyotik Mayanın Yüksek Kolesterol İçeren Diyetle Beslenen Sıçanlarda Kolesterolü Düşürücü Ajan Olarak Kullanılabilirliğinin Araştırılması

Öz:

Probiotic yeast, Cryptococcus humicola M5-2 strain, which has high cholesterol assimilation feature and isolated from traditionallyproduced cheese, was investigated in vivo. This study was conducted to determine cholesterol assimilation ability of C. humicolaM5-2 in vivo and specify the effect of the strain on serum total cholesterol, HDL/LDL cholesterol and triglycerides levels in rats fed oncholesterol-enriched diet. C. humicola had the ability to assimilate cholesterol at the rate of 73.33% in media. The strain was used withtwo different concentrations in animal feed (high and low doses containing 2% and 0.1% lyophilized strains, respectively). When thetreatment groups were compared, low dose feeding group had the positive results in terms of testing values. According to the resultsof serum analysis, triglyceride and total cholesterol level were decreased by 25% and 1.34% respectively. Especially, decreasing thepercentage rate of triglyceride has not obtained in other in vivo studies. It is thought that health promoting effect will be possible whenthe obtained isolate is consumed with fermented foods.

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Şanlıdere Aloğlu H, Demir Özer E, ÖNER Z, SAVAS H, UZ E (2015). Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. , 685 - 689.
Chicago	Şanlıdere Aloğlu Hatice,Demir Özer Ezgi,ÖNER Zübeyde,SAVAS Hasan Basri,UZ Efkan Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. (2015): 685 - 689.
MLA	Şanlıdere Aloğlu Hatice,Demir Özer Ezgi,ÖNER Zübeyde,SAVAS Hasan Basri,UZ Efkan Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. , 2015, ss.685 - 689.
AMA	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. . 2015; 685 - 689.
Vancouver	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. . 2015; 685 - 689.
IEEE	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E "Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet." , ss.685 - 689, 2015.
ISNAD	Şanlıdere Aloğlu, Hatice vd. "Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet". (2015), 685-689.

APA	Şanlıdere Aloğlu H, Demir Özer E, ÖNER Z, SAVAS H, UZ E (2015). Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21(5), 685 - 689.
Chicago	Şanlıdere Aloğlu Hatice,Demir Özer Ezgi,ÖNER Zübeyde,SAVAS Hasan Basri,UZ Efkan Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 21, no.5 (2015): 685 - 689.
MLA	Şanlıdere Aloğlu Hatice,Demir Özer Ezgi,ÖNER Zübeyde,SAVAS Hasan Basri,UZ Efkan Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.21, no.5, 2015, ss.685 - 689.
AMA	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2015; 21(5): 685 - 689.
Vancouver	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2015; 21(5): 685 - 689.
IEEE	Şanlıdere Aloğlu H,Demir Özer E,ÖNER Z,SAVAS H,UZ E "Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21, ss.685 - 689, 2015.
ISNAD	Şanlıdere Aloğlu, Hatice vd. "Investigation of a Probiotic Yeast as a Cholesterol Lowering Agent on Rats Fed on a High Cholesterol Enriched Diet". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 21/5 (2015), 685-689.