Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?
Yıl: 2015 Cilt: 21 Sayı: 5 Sayfa Aralığı: 673 - 676 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?
Öz: Serulein ile indüklenmiş akut pankreatiti (AP)nin uterusa etkisi ve melatonin uygulamasının muhtemel uterus koruyucuetkileri araştırıldı. Yirmi sekiz rat dört gruba ayrıldı: (1) Kontrol grubu (n = 7); (2) melatonin grubu (n = 7); (3) serulein grubu (n= 7); (4) melatonin + serulein grubu (n = 7). AP, genç dişi hayvanlara saatte bir (50 μg/kg) dozunda 4 kez verilen intraperitonalserulein enjeksiyonu ile indüklenmiştir. Melatonin (20 mg/kg) AP indüksiyonundan 30 dakika önce intraperitonal enjeksiyonyolu ile verildi. Ratlar seruleinin son enjeksiyonundan 12 saat sonra sakrifiye edildi ve uterusları histopatoloj ik değerlendirmeiçin alındı. Ortalama vücut ağırlığı ve uterusun ıslak ağırlıkları kaydedildi. Endo-miyometriyumdaki histoloj ik değişikliklerinderecesi, ödem, kanama, nekroz, lökosit infiltrasyonu, endometriyal proliferasyon ve endometrial kalınlık skorlaması için H-Puanyöntemi kullanıldı. Her grupta tedaviden sonra ortalama vücut ağırlığında anlamlı bir farkın olmadığı gözlendi. Kontrol veserulein verilen ratlar arasındaki uterus ıslak ağırlıkları anlamlı derecede farklı (P<0.01) olduğu tespit edildi. Serulein grubundaendometriyal kalınlık, ödem, kanama, nekroz ve lökosit infiltrasyonu melatonin ve kontrol grubuna oranla anlamlı derecededaha fazla olduğu görüldü (P<0.01). Daha önceden melatonin uygulanan grupta sadece serulein uygulanan gruba oranlahistoloj ik olarak yapısal bozuklukların normale döndüğü ve uterus ıslak ağırlığının anlamlı ölçüde azaldığı gözlendi. Melatoninuygulamasının, uterusun endometriumu üzerine seruleinden kaynaklanan olumsuz etkilerin profilaksisinde önemli bir roloynayabileceği düşünülmektedir.
Anahtar Kelime: Konular:
Melatonin Serulein in Olumsuz Etkilerine Karşı Endometriyumu Koruyabilir mi?
Öz: We investigated the effects of a caerulein-induced acute pancreatitis (AP) on uterus and possible uterine protective effects ofmelatonin administration. Twenty-eight animals were divided into four groups: (1) control group (n = 7); (2) melatonin group(n = 7); (3) caerulein group (n = 7); (4) melatonin + caerulein group (n = 7). AP was induced by 4 intraperitoneal inj ection ofcaerulein given hourly (50 μg/kg) into young female animals. Melatonin (20 mg/kg) was given via intraperitoneal inj ection30 min prior to the induction of AP. The rats were sacrificed by decapitation 12 h after the last inj ection of caerulein and theiruterus were taken for histopathological evaluation. Mean body weight and uterine wet weight was recorded. The H-Scoremethod was used to score the degree of histological changes of endo-myometrium edema, hemorrhage, necrosis, leucocyteinfiltration, endometrial proliferation and endometrial thickness. There was no significant difference in the mean body weightobserved after treatment in each group. The uterine wet weight differences between the control and caerulein given rats weresignificant (P<0.01). The endometrial thickness, edema, hemorrhage, necrosis and leucocyte infiltration of the caerulein groupwas significantly higher than the control and melatonin groups (P<0.01). It was observed that preteratment with melatoninnormalized histological abnormalities and significantly reduced uterine wet weight as compared with the caerulein onlygroup. Melatonin application may play an important role in the prophylaxis of uterine endometrium arising from adverseeffects of caerulein.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Şahin L, Şahin H, KARAHAN F, GÜL S, BAHAR L, GÜL M, ÖZAKŞİT M (2015). Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. , 673 - 676. |
| Chicago | Şahin Levent,Şahin Hilal,KARAHAN Feride,GÜL SEMİR,BAHAR LEYLA,GÜL MEHMET,ÖZAKŞİT Müzeyyen Gülnur Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. (2015): 673 - 676. |
| MLA | Şahin Levent,Şahin Hilal,KARAHAN Feride,GÜL SEMİR,BAHAR LEYLA,GÜL MEHMET,ÖZAKŞİT Müzeyyen Gülnur Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. , 2015, ss.673 - 676. |
| AMA | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. . 2015; 673 - 676. |
| Vancouver | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. . 2015; 673 - 676. |
| IEEE | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M "Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?." , ss.673 - 676, 2015. |
| ISNAD | Şahin, Levent vd. "Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?". (2015), 673-676. |
| APA | Şahin L, Şahin H, KARAHAN F, GÜL S, BAHAR L, GÜL M, ÖZAKŞİT M (2015). Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21(5), 673 - 676. |
| Chicago | Şahin Levent,Şahin Hilal,KARAHAN Feride,GÜL SEMİR,BAHAR LEYLA,GÜL MEHMET,ÖZAKŞİT Müzeyyen Gülnur Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 21, no.5 (2015): 673 - 676. |
| MLA | Şahin Levent,Şahin Hilal,KARAHAN Feride,GÜL SEMİR,BAHAR LEYLA,GÜL MEHMET,ÖZAKŞİT Müzeyyen Gülnur Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.21, no.5, 2015, ss.673 - 676. |
| AMA | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2015; 21(5): 673 - 676. |
| Vancouver | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2015; 21(5): 673 - 676. |
| IEEE | Şahin L,Şahin H,KARAHAN F,GÜL S,BAHAR L,GÜL M,ÖZAKŞİT M "Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21, ss.673 - 676, 2015. |
| ISNAD | Şahin, Levent vd. "Can Melatonin Protect the Endometrium from the Adverse Effects of Caerulein?". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 21/5 (2015), 673-676. |
