Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

İNÖNÜ KÖSEOĞLU, Handan; TAŞLIYURT, Türker; Yılmaz, Abdulkerim; SAĞCAN, Mustafa; ŞAHAN, Abdülkadir Geylani; ŞIVGIN, Hakan; doruk, sibel

Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

Abdülkadir Geylani ŞAHAN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Abdülkerim YILMAZ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Türker TAŞLIYURT, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Sibel DORUK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Handan İNÖNÜ KÖSEOĞLU, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Hakan ŞIVGIN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Mustafa SAĞCAN (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Cumhuriyet Tıp Dergisi (ELEKTRONİK)

4 0

Yıl: 2014 Cilt: 36 Sayı: 2 Sayfa Aralığı: 178 - 183 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

Öz:

Amaç. Kronik obstrüktif akciğer hastalığı (KOAH) kronik, ilerleyici, inflamatuar bir hastalıktır.Oksidatif stres ve havayolu inflamasyonu hastalığın ana patofizyolojik etkenleridir. Bu çalışmadabir anjiyotensin reseptör blokeri (ARB) olan telmisartanın KOAHdaki antiinflamatuar etkisiniaraştırmayı amaçladık. Yöntem. Çalışmaya 25i telmisartan kullanan 50 KOAH hastası alındı.Hastaların yoğunlaştırılmış soluk havası (EBC) örnekleri EBC toplama cihazı kullanılarak toplandı(Ecoscreen, Jaeger, Germany). EBC örnekleri analiz edildi ve enzim immunoassay metodu(Cayman Chemical Co. Michigan, USA) kullanılarak 8-izoprostan düzeyleri ölçüldü. Bulgular.Her iki grup arasında ortalama yaş, cinsiyet ve sigara kullanımı açısından fark yoktu. Telmisartankullanan ve kullanmayan grupta 8-izoprostan düzeyleri sırasıyla 33,98 ve 35,91 pg/mL olarakölçüldü, iki grup arasındaki fark istatistiksel olarak anlamlı bulundu (p<0,001). Sonuç. ARBlerinoksidatif stres ve inflamasyonu azaltarak hastalığın patofizyolojisi ve ilerleyişine olumlu etkileriolabilir.

Anahtar Kelime:

Konular: Cerrahi

Kronik obstruktif akciğer hastalığında telmisartan ın antiinf lamatuar etkinliği: Yoğunlaştırılmış soluk havasında 8-isoprostan konsantrasyonu *

Öz:

Aim. Chronic obstructive pulmonary disease (COPD) is a chronic, progressive, inflammatorydisease. Oxidative stress and airway inflammation are its main pathophysiologic components. Inthis study, our aim was to investigate the effect of an angiotensin receptor blocker (ARB)telmisartan which also exerts antiinflammatory effects on inflammation and oxidative stress inCOPD. Method. The study group consisted of 50 stable COPD patients including 25 telmisartanusers. Exhaled breath condensate (EBC) samples of the cases were collected using an EBCcollecting device (Ecoscreen, Jaeger, Germany). EBC samples were analyzed and 8-isoprostanelevels were measured using an enzyme immunoassay method (Cayman Chemical Co. Michigan,USA). Results. Any intergroup difference as for mean age, distribution of gender and smokingwere not found. In telmisartan users, and nonusers mean 8-isoprostane levels were 33.98 and 35.91pg/mL, respectively with a statistically significant intergroup difference (p<0.001) Conclusion.We think that ARBs decrease oxidative stress and inflammation, and thus exert favourable effectson the pathophysiology and progression of COPD.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ŞAHAN A, Yılmaz A, TAŞLIYURT T, doruk s, İNÖNÜ KÖSEOĞLU H, ŞIVGIN H, SAĞCAN M (2014). Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. , 178 - 183.
Chicago	ŞAHAN Abdülkadir Geylani,Yılmaz Abdulkerim,TAŞLIYURT Türker,doruk sibel,İNÖNÜ KÖSEOĞLU Handan,ŞIVGIN Hakan,SAĞCAN Mustafa Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. (2014): 178 - 183.
MLA	ŞAHAN Abdülkadir Geylani,Yılmaz Abdulkerim,TAŞLIYURT Türker,doruk sibel,İNÖNÜ KÖSEOĞLU Handan,ŞIVGIN Hakan,SAĞCAN Mustafa Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. , 2014, ss.178 - 183.
AMA	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. . 2014; 178 - 183.
Vancouver	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. . 2014; 178 - 183.
IEEE	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M "Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate." , ss.178 - 183, 2014.
ISNAD	ŞAHAN, Abdülkadir Geylani vd. "Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate". (2014), 178-183.

APA	ŞAHAN A, Yılmaz A, TAŞLIYURT T, doruk s, İNÖNÜ KÖSEOĞLU H, ŞIVGIN H, SAĞCAN M (2014). Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. Cumhuriyet Tıp Dergisi (ELEKTRONİK), 36(2), 178 - 183.
Chicago	ŞAHAN Abdülkadir Geylani,Yılmaz Abdulkerim,TAŞLIYURT Türker,doruk sibel,İNÖNÜ KÖSEOĞLU Handan,ŞIVGIN Hakan,SAĞCAN Mustafa Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. Cumhuriyet Tıp Dergisi (ELEKTRONİK) 36, no.2 (2014): 178 - 183.
MLA	ŞAHAN Abdülkadir Geylani,Yılmaz Abdulkerim,TAŞLIYURT Türker,doruk sibel,İNÖNÜ KÖSEOĞLU Handan,ŞIVGIN Hakan,SAĞCAN Mustafa Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. Cumhuriyet Tıp Dergisi (ELEKTRONİK), vol.36, no.2, 2014, ss.178 - 183.
AMA	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. Cumhuriyet Tıp Dergisi (ELEKTRONİK). 2014; 36(2): 178 - 183.
Vancouver	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. Cumhuriyet Tıp Dergisi (ELEKTRONİK). 2014; 36(2): 178 - 183.
IEEE	ŞAHAN A,Yılmaz A,TAŞLIYURT T,doruk s,İNÖNÜ KÖSEOĞLU H,ŞIVGIN H,SAĞCAN M "Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate." Cumhuriyet Tıp Dergisi (ELEKTRONİK), 36, ss.178 - 183, 2014.
ISNAD	ŞAHAN, Abdülkadir Geylani vd. "Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate". Cumhuriyet Tıp Dergisi (ELEKTRONİK) 36/2 (2014), 178-183.