The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)

ALTUN, Necdet Şükrü; SONGÜR, Murat; ŞAHİN, Ercan; TAKE KAPLANOĞLU, Gülnur; KALEM, Mahmut; DEMİR, Tuğcan

The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)

Murat SONGÜR, (Bülent Ecevit Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Zonguldak, Türkiye)

Ercan ŞAHİN, (Bülent Ecevit Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Zonguldak, Türkiye)

Tuğcan DEMİR, (Bahçeşehir Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, İstanbul, Türkiye)

Mahmut KALEM, (Ankara Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Ankara, Türkiye)

Gülnur TAKE KAPLANOĞLU, (Gazi Üniversitesi,Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye)

Necdet Şükrü ALTUN (Gazi Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Ankara, Türkiye)

Acta Orthopaedica et Traumatologica Turcica

1 0

Yıl: 2015 Cilt: 49 Sayı: 3 Sayfa Aralığı: 311 - 318 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)

Öz:

Objective: Bone protein extract (BPE) usually requires a carrier or a scaffold for implantation. We aimed to compare the effect of equine-derived BPE, an osteoinductive agent composed of a high amount of type-I collagen and other bone proteins (Colloss-E), with that of human demineralized bone matrix (DBM) for treating cavitary bone defects not requiring scaffold use. Methods: Rabbit distal femoral condyle was used as a stable cavitary bone defect model. Bone defects of 6-mm diameter and 10 12-mm depth were created in the femoral condyles. Rabbits were assigned into the equine-derived BPE (BPE) , human-derived DBM (DBM), and control (C) groups. Approximately 20 mg of BPE was implanted into the defect in the equine-derived BPE group (n=6), whereas 0.3 cc of DBM was implanted in the DBM group (n=6). Defects were left empty in the C group (n=6). The defect area was histologically examined after 6 weeks. Results: There were no instances of macroscopic defect collapse or failure. Histopathological examination revealed that the BPE group had better scores (statistically significant) than both the other groups in terms of quality of union. The BPE group also had higher scores than the DBM group in terms of graft incorporation and new-bone formation. Conclusion: The current study revealed results consistent with those of the previous studies concerning BPEs. Equine-derived BPE was found to be successful for treating cavitary bone defects not requiring scaffold use.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	SONGÜR M, ŞAHİN E, DEMİR T, KALEM M, TAKE KAPLANOĞLU G, ALTUN N (2015). The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). , 311 - 318.
Chicago	SONGÜR Murat,ŞAHİN Ercan,DEMİR Tuğcan,KALEM Mahmut,TAKE KAPLANOĞLU Gülnur,ALTUN Necdet Şükrü The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). (2015): 311 - 318.
MLA	SONGÜR Murat,ŞAHİN Ercan,DEMİR Tuğcan,KALEM Mahmut,TAKE KAPLANOĞLU Gülnur,ALTUN Necdet Şükrü The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). , 2015, ss.311 - 318.
AMA	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). . 2015; 311 - 318.
Vancouver	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). . 2015; 311 - 318.
IEEE	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N "The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)." , ss.311 - 318, 2015.
ISNAD	SONGÜR, Murat vd. "The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)". (2015), 311-318.

APA	SONGÜR M, ŞAHİN E, DEMİR T, KALEM M, TAKE KAPLANOĞLU G, ALTUN N (2015). The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica, 49(3), 311 - 318.
Chicago	SONGÜR Murat,ŞAHİN Ercan,DEMİR Tuğcan,KALEM Mahmut,TAKE KAPLANOĞLU Gülnur,ALTUN Necdet Şükrü The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica 49, no.3 (2015): 311 - 318.
MLA	SONGÜR Murat,ŞAHİN Ercan,DEMİR Tuğcan,KALEM Mahmut,TAKE KAPLANOĞLU Gülnur,ALTUN Necdet Şükrü The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica, vol.49, no.3, 2015, ss.311 - 318.
AMA	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica. 2015; 49(3): 311 - 318.
Vancouver	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY). Acta Orthopaedica et Traumatologica Turcica. 2015; 49(3): 311 - 318.
IEEE	SONGÜR M,ŞAHİN E,DEMİR T,KALEM M,TAKE KAPLANOĞLU G,ALTUN N "The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)." Acta Orthopaedica et Traumatologica Turcica, 49, ss.311 - 318, 2015.
ISNAD	SONGÜR, Murat vd. "The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study ( EXPERIMENTAL STUDY)". Acta Orthopaedica et Traumatologica Turcica 49/3 (2015), 311-318.