The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting

Turan, İbrahim; Demir, Selim; MENTEŞE, Ümit; DOĞAN, Süheyla; DEMİRBAŞ, Mine; KILIÇ, Aşkın; DOĞAN, Orhan Veli; AYKAN, Ahmet Çağrı; KARAHAN, Süleyman Caner; USTA, SEFER

The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting

Ümit MENTEŞE, (SB Ahi Evren Kalp Damar Cerrahi Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Trabzon, Türkiye)

Orhan Veli DOĞAN, (Sakarya Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi, Sakarya, Türkiye)

Süheyla DOĞAN, (SB Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

İbrahim TURAN, (Gümüşhane Üniversitesi, Tıp Fakültesi, Genetik ve Biyoteknik Bölümü, Gümüşhane, Türkiye)

Sefer USTA, (SB Ahi Evren Kalp Damar Cerrahi Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Trabzon, Türkiye)

Mine DEMİRBAŞ, (SB Ahi Evren Kalp Damar Cerrahi Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Trabzon, Türkiye)

Ahmet Çağrı AYKAN, (SB Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Aşkın KILIÇ, (SB Ahi Evren Kalp Damar Cerrahi Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Trabzon, Türkiye)

Selim DEMİR, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Süleyman Caner KARAHAN (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Türk Göğüs Kalp Damar Cerrahisi Dergisi

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Yıl: 2015 Cilt: 23 Sayı: 2 Sayfa Aralığı: 245 - 250 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting

Öz:

Amaç: Bu çalışmada, iskemi modifiye albümin (İMA)ninon-pump koroner arter baypas greftleme (ONCABG)de ameliyatsırası miyokard enfarktüsünü (PME) erken dönemde öngörebilmepotansiyeli değerlendirildi.Çalışmaplanı: Çalışmaya elektif izole ONCABG yapılan50 hasta (41 erkek, 9 kadın; ort. yaş 66 yıl; dağılım 56-75yıl) dahil edildi. Hastalar, ameliyat sırası EKG bulguları vekardiyak troponin I (cTnI) değerlerine göre, PME olanlar (n=8)ve PME olmayanlar (NPME; n=42) olarak gruplandırıldı.Serum İMA düzeyleri ameliyat öncesinde, aortik kros klempkonulduktan 20 dakika sonra, klemp kaldırıldıktan 30 dakika,3, 6, 12 ve 24 saat sonra ölçüldü.Bul gu lar: Klemp kalktıktan 30 dakika, 3, 6 ve 12 saat sonraİMA düzeyleri PME grubunda, NPME grubuna kıyasla, dahayüksekti (sırasıyla, p=0.002, p=0.048, p=0.023, p=0.007).Hem PME hem de NPME grubunda İMA düzeyleri aortik krosklemp konulduktan 20 dakika sonra, ameliyat öncesi İMAdüzeylerine kıyasla yükselmişti (sırasıyla p=0.0001, p=0.038).Sonuç: Çalışma bulgularımız, İMAnın ONCABG yapılanhastalarda miyokard infarktüsü için erken bir belirteçolabileceğini göstermektedir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi Cerrahi

On- pump koroner arter baypas greftlemede miyokarde nfarktüsü ile iskemi modifiye albüminin ilişkisi

Öz:

Background: This study aims to evaluate the potential ofischemia-modified albumin (IMA) to predict the myocardialinfarction in on pump coronary artery bypass grafting(ONCABG) patients.Methods: Fifty elective isolated ONCABG patients (41 males,9 females; mean age 66 years; range 56 to 75 years) were includedin the study. Patients were divided into perioperative myocardialinfarction (PMI; n=8) and non-infarction (NPMI; n=42) groupsaccording to perioperative cardiac troponin I (cTnI) values andECG findings. Serum IMA levels were measured preoperatively,20 minutes after aortic cross clamping, 30 minutes, at 3, 6,12 and 24 hours after declamping.Results: Compared to the NPMI group, the declamping 30minutes, 3, 6 and 12 hours IMA levels were higher in the PMIgroup (p=0.002, p=0.048, p=0.023, p=0.007, respectively). Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion: Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	MENTEŞE Ü, DOĞAN O, DOĞAN S, Turan İ, USTA S, DEMİRBAŞ M, AYKAN A, KILIÇ A, Demir S, KARAHAN S (2015). The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. , 245 - 250.
Chicago	MENTEŞE Ümit,DOĞAN Orhan Veli,DOĞAN Süheyla,Turan İbrahim,USTA SEFER,DEMİRBAŞ Mine,AYKAN Ahmet Çağrı,KILIÇ Aşkın,Demir Selim,KARAHAN Süleyman Caner The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. (2015): 245 - 250.
MLA	MENTEŞE Ümit,DOĞAN Orhan Veli,DOĞAN Süheyla,Turan İbrahim,USTA SEFER,DEMİRBAŞ Mine,AYKAN Ahmet Çağrı,KILIÇ Aşkın,Demir Selim,KARAHAN Süleyman Caner The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. , 2015, ss.245 - 250.
AMA	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. . 2015; 245 - 250.
Vancouver	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. . 2015; 245 - 250.
IEEE	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S "The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting." , ss.245 - 250, 2015.
ISNAD	MENTEŞE, Ümit vd. "The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting". (2015), 245-250.

APA	MENTEŞE Ü, DOĞAN O, DOĞAN S, Turan İ, USTA S, DEMİRBAŞ M, AYKAN A, KILIÇ A, Demir S, KARAHAN S (2015). The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 23(2), 245 - 250.
Chicago	MENTEŞE Ümit,DOĞAN Orhan Veli,DOĞAN Süheyla,Turan İbrahim,USTA SEFER,DEMİRBAŞ Mine,AYKAN Ahmet Çağrı,KILIÇ Aşkın,Demir Selim,KARAHAN Süleyman Caner The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. Türk Göğüs Kalp Damar Cerrahisi Dergisi 23, no.2 (2015): 245 - 250.
MLA	MENTEŞE Ümit,DOĞAN Orhan Veli,DOĞAN Süheyla,Turan İbrahim,USTA SEFER,DEMİRBAŞ Mine,AYKAN Ahmet Çağrı,KILIÇ Aşkın,Demir Selim,KARAHAN Süleyman Caner The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.23, no.2, 2015, ss.245 - 250.
AMA	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2015; 23(2): 245 - 250.
Vancouver	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2015; 23(2): 245 - 250.
IEEE	MENTEŞE Ü,DOĞAN O,DOĞAN S,Turan İ,USTA S,DEMİRBAŞ M,AYKAN A,KILIÇ A,Demir S,KARAHAN S "The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 23, ss.245 - 250, 2015.
ISNAD	MENTEŞE, Ümit vd. "The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting". Türk Göğüs Kalp Damar Cerrahisi Dergisi 23/2 (2015), 245-250.