Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise

Karadag, Cetin Hakan; TOPUZ, RUHAN DENİZ; Süt, Necdet; VARDAR, Selma Arzu; ÇALIŞKAN, Semra; ÖZEN TOPÇU, Serap; Gürel, Elif Ezgi; PALABIYIK, Orkide

Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise

Selma Arzu VARDAR, (Trakya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Edirne, Türkiye)

Orkide PALABIYIK, (Trakya Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Edirne, Türkiye)

Ruhan Deniz TOPUZ, (Trakya Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Edirne, Türkiye)

Elif Ezgi GÜREL, (Trakya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Edirne, Türkiye)

Semra ÇALIŞKAN, (Trakya Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Edirne, Türkiye)

Serap ÖZEN TOPÇU, (Trakya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Edirne, Türkiye)

Necdet SÜT, (Trakya Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Edirne, Türkiye)

Çetin Hakan KARADAĞ (Trakya Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Edirne, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2015 Cilt: 45 Sayı: 2 Sayfa Aralığı: 298 - 305 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise

Öz:

Background/aim: Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes.We compared the hemodynamic efects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed byreperfusion in exercised rat hearts with nonexercised ones.Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups afer a running protocol for 5 days and 4 nonexercised(NE) groups. In the frst protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the secondprotocol, diferent doses of isatin (0.1, 10, 100 µM/L) were added to the perfusion solution before ANP in 3 E and 3 NE groups. Lefventricular developed pressure (LVDP) and maximum and minimum rates of change in lef ventricular pressure (dP/dtmax and dP/dtmin) were recorded.Results: Higher LVDP and dP/dtmin values were observed in the E group than the NE group following addition of ANP before ischemia.Values of dP/dtmax were higher in the E group at the frst minute of reperfusion period. Hemodynamic diference was not observedbetween groups given the same amount of isatin before ANP.Conclusion: Tis study indicated that higher ANP concentrations before ischemia were more efective on the lef ventricle contractilityand relaxation functions in the hearts that were exposed to exercise.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Clerico A. Vittorini S. Te cardiac natriuretic hormone system. In: Clerico A, Emdin M, editors. Natriuretic Peptides: Te Hormones of the Heart. Trento, Italy: Springer-Verlag Italia; 2006. pp. 2164.
2. Raine AE, Erne P, Bürgisser E, Müller FB, Bolli P, Burkart F, Bühler FR. Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 1986; 315: 533537.
3. Karakuşoğlu Ö, Vardar SA, Kunduracılar H, Süt N. Efects of short duration supramaximal exercise on plasma atrial natriuretic peptide concentrations in healthy subjects. Turkiye Klinikleri J Sports Sci 2010; 2: 16.
4. Mandroukas K, Zakas A, Aggelopoulou N, Christoulas K, Abatzides G, Karamouzis M. Atrial natriuretic factor responses to submaximal and maximal exercise. Br J Sports Med 1995; 29: 248251.
5. Onuoha GN, Nicholls DP, Patterson A, Beringer T. Neuropeptide secretion in exercise. Neuropeptides 1998; 32: 319325.
6. Gerczuk PZ, Kloner RA. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. J Am Coll Cardiol 2012; 59: 969978.
7. Wakui S, Sezai A, Tenderich G, Hata M, Osaka S, Taniguchi Y, Koerfer R, Minami K. Experimental investigation of direct myocardial protective efect of atrial natriuretic peptide in cardiac surgery. J Torac Cardiovasc Surg 2010; 139: 918925.
8. Yang XM, Philipp S, Downey JM, Cohen MV. Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts. Basic Res Cardiol 2006; 101: 311318.
9. Kasama S, Furuya M, Toyama T, Ichikawa S, Kurabayashi M. Efect of atrial natriuretic peptide on lef ventricular remodelling in patients with acute myocardial infarction. Eur Heart J 2008; 29: 14851494.
10. Sangawa K, Nakanishi K, Ishino K, Inoue M, Kawada M, Sano S. Atrial natriuretic peptide protects against ischemia-reperfusion injury in the isolated rat heart. Ann Torac Surg 2004; 77: 233 237.
11. Dickson EW, Hogrefe CP, Ludwig PS, Ackermann LW, Stoll LL, Denning GM. Exercise enhances myocardial ischemic tolerance via an opioid receptor-dependent mechanism. Am J Physiol Heart Circ Physiol 2008; 294: H402408.
12. Opie LH. Ventricular function. In: Opie LH, editor. Heart Physiology from Cell to Circulation. 3rd ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 1998. pp. 343389.
13. Date H, Imamura T, Onitsuka H, Maeno M, Watanabe R, Nishihira K, Matsuo T, Eto T. Diferential increase in natriuretic peptides in elite dynamic and static athletes. Circ J 2003; 67: 691696.
14. Vardar SA, Aktoz M, Karakuşoğlu Ö, Kunduracilar H. Te alteration of plasma atrial natriuretic peptide levels induced by postural changes in archery athletes. Trakya Univ Tıp Fak Derg 2010; 27: 275280 (in Turkish with English abstract).
15. de Almeida JC, Alves CL, de Abreu LC, Sato MA, Fonseca FL, de Mello Monteiro CB, Vanderlei LC, Macedo H Jr, Tavares CM, Herrero D et al. Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise. Int Arch Med 2012; 5: 4.
16. Clarkson PB, Wheeldon NM, Macleod C, Coutie W, MacDonald TM. Acute efects of atrial natriuretic peptide on lef ventricular diastolic function. A pulsed wave Doppler study in man. Eur Heart J 1995; 16: 17101715.
17. Rauch U, Schulze K, Witzenbichler B, Schultheiss HP. Alteration of the cytosolic-mitochondrial distribution of high-energy phosphates during global myocardial ischemia may contribute to early contractile failure. Circ Res 1994; 75: 760769.
18. Gavin TP, Wagner PD. Efect of short-term exercise training on angiogenic growth factor gene responses in rats. J Appl Physiol 2001; 90: 12191226.
19. Demirel HA, Powers SK, Zergeroglu MA, Shanely RA, Hamilton K, Coombes J, Naito Hl. Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol 2001; 91: 22052212.
20. Difee GM, Seversen EA, Titus MM. Exercise training increases the Ca 2+ sensitivity of tension in rat cardiac myocytes. J Appl Physiol 2001; 91: 309315.
21. Duncker DJ, Bache RJ. Regulation of coronary blood fow during exercise. Physiol Rev 2008; 88: 10091086.
22. Pataki I, Adamik A, Telegdy G. Isatin (indole-2,3-dione) inhibits natriuretic peptide-induced hyperthermia in rats. Peptides 2000; 21: 373377.
23. Yang XM, Philipp S, Downey JM, Cohen MV. Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts. Basic Res Cardiol 2006; 101: 311318.
24. Zhong B, Wang DH. N-Oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia- reperfusion injury via activation of TRPV1. Am J Physiol Heart Circ Physiol 2008; 295: H728735.
25. Yaguchi Y, Satoh H, Wakahara N, Katoh H, Uehara A, Terada H, Fujise Y, Hayashi H. Protective efects of hydrogen peroxide against ischemia/reperfusion injury in perfused rat hearts. Circ J 2003; 67: 253258.

APA	VARDAR S, PALABIYIK O, TOPUZ R, Gürel E, ÇALIŞKAN S, ÖZEN TOPÇU S, Süt N, Karadag C (2015). Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. , 298 - 305.
Chicago	VARDAR Selma Arzu,PALABIYIK Orkide,TOPUZ RUHAN DENİZ,Gürel Elif Ezgi,ÇALIŞKAN Semra,ÖZEN TOPÇU Serap,Süt Necdet,Karadag Cetin Hakan Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. (2015): 298 - 305.
MLA	VARDAR Selma Arzu,PALABIYIK Orkide,TOPUZ RUHAN DENİZ,Gürel Elif Ezgi,ÇALIŞKAN Semra,ÖZEN TOPÇU Serap,Süt Necdet,Karadag Cetin Hakan Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. , 2015, ss.298 - 305.
AMA	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. . 2015; 298 - 305.
Vancouver	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. . 2015; 298 - 305.
IEEE	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C "Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise." , ss.298 - 305, 2015.
ISNAD	VARDAR, Selma Arzu vd. "Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise". (2015), 298-305.

APA	VARDAR S, PALABIYIK O, TOPUZ R, Gürel E, ÇALIŞKAN S, ÖZEN TOPÇU S, Süt N, Karadag C (2015). Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. Turkish Journal of Medical Sciences, 45(2), 298 - 305.
Chicago	VARDAR Selma Arzu,PALABIYIK Orkide,TOPUZ RUHAN DENİZ,Gürel Elif Ezgi,ÇALIŞKAN Semra,ÖZEN TOPÇU Serap,Süt Necdet,Karadag Cetin Hakan Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. Turkish Journal of Medical Sciences 45, no.2 (2015): 298 - 305.
MLA	VARDAR Selma Arzu,PALABIYIK Orkide,TOPUZ RUHAN DENİZ,Gürel Elif Ezgi,ÇALIŞKAN Semra,ÖZEN TOPÇU Serap,Süt Necdet,Karadag Cetin Hakan Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. Turkish Journal of Medical Sciences, vol.45, no.2, 2015, ss.298 - 305.
AMA	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. Turkish Journal of Medical Sciences. 2015; 45(2): 298 - 305.
Vancouver	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise. Turkish Journal of Medical Sciences. 2015; 45(2): 298 - 305.
IEEE	VARDAR S,PALABIYIK O,TOPUZ R,Gürel E,ÇALIŞKAN S,ÖZEN TOPÇU S,Süt N,Karadag C "Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise." Turkish Journal of Medical Sciences, 45, ss.298 - 305, 2015.
ISNAD	VARDAR, Selma Arzu vd. "Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise". Turkish Journal of Medical Sciences 45/2 (2015), 298-305.