Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement

Gürsoy, Mustafa Ozan; TURSUN, İrfan; Kalçık, Macit; Özkan, Mehmet; HAYKIR SOLAY, Aslı; GÜRSOY, Semra; ALPUA, Mehmet; DEMİRTAŞ, Hale; ÇOBANLI TOKAT, Müge; KARAKOYUN, Sülayman; ERCAN, Gülten

Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement

Mustafa Ozan GÜRSOY, (Iğdır Devlet Hastanesi, Kardiyoloji Kliniği, Iğdır, Türkiye)

Hale DEMİRTAŞ, (Iğdır Devlet Hastanesi, Kardiyoloji Kliniği, Iğdır, Türkiye)

İrfan TURSUN, (Iğdır Devlet Hastanesi, İç Hastalıkları Kliniği, Iğdır, Türkiye)

Mehmet ALPUA, (Iğdır Devlet Hastanesi, İç Hastalıkları Kliniği, Iğdır, Türkiye)

Aslı HAYKIR SOLAY, (Sağlık Bakanlığı, Iğdır Devlet Hastanesi, İnfeksiyon Hastalıkları Anabilim Dalı, Iğdır Türkiye)

Müge ÇOBANLI TOKAT, (Sağlık Bakanlığı, Iğdır Devlet Hastanesi, İnfeksiyon Hastalıkları Anabilim Dalı, Iğdır Türkiye)

Gülten ERCAN, (Iğdır Devlet Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Iğdır, Türkiye)

Semra GÜRSOY, (Iğdır Devlet Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Iğdır, Türkiye)

Macit KALÇIK, (Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Sülayman KARAKOYUN, (Doç. Dr. Yaşar Eryılmaz Doğubeyazıt Devlet Hastanesi, Kardiyoloji Kliniği, Ağrı, Türkiye)

Mehmet ÖZKAN, (Kafkas Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kars, Türkiye)

Diğer Yazarlar

Türk Kardiyoloji Derneği Arşivi

1 2

Yıl: 2015 Cilt: 43 Sayı: 3 Sayfa Aralığı: 242 - 249 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement

Öz:

Amaç: Bruselloz gelişmekte olan ülkelerde görülebilen önemli bir enfeksiyöz hastalıktır ve kardiyovasküler sistem dahil herhangi bir organı tutabilir. Bu çalışmada, brusellozlu hastalarda kalp ve endotel fonksiyonları incelendi.Yöntemler: Türkiyede 2011 ve 2013 yılları arasında gerçekleştirilen bu kesitsel çalışmaya brusellozlu 73 hasta ile sağlıklı 75 gönüllü alındı. Rose-Bengal testi, pozitif brusella standart tüp aglütinasyon testi, Coombs STA ve/veya kandan brusella türlerinin izolasyonu ile bruselloz tanısı konuldu. Hastalar üç gruba ayrıldı: Grup I akut brusellozlu, grup II subakut brusellozlu ve grup III kronik brusellozlu. Sağlıklı gönüllüler grup IVü oluşturdu. Tüm hastalara transtorasik ekokardiyografi ve brakiyal arter akım-ilişkili dilatasyon (FMD) testi uygulandı.Bulgular: Grup I-IV sırasıyla 35, 18, 20 hasta ve 75 sağlıklı gönüllüden oluşmaktaydı. En sık bulgular, artralji (%82), ateş (%92) ve halsizlik (%97) idi. Ekokardiyografik incelemede sol ventrikül sistolik ve diyastolik fonksiyonları ve kapak fonksiyonları açısından dört grup arasında fark saptanmadı. Hiperemi sonrası ölçülen brakiyal arter çapları gruplar arasında anlamlı olarak farklı idi (p=0.002). Post-hoc testine göre kronik brusellozdan oluşan grup IIIde hiperemi sonrası brakiyal arter çapı diğer gruplara göre anlamlı olarak daha düşük idi (sırasıyla, p=0.02, p=0.004 ve p=0.001). Benzer şekilde grup IIIde FMD değerleri grup I, II ve IVe göre (p<0.001 hepsi için) anlamlı olarak düşük idi.Sonuç: Bruselloz kronik semptomlu hastalarda belirgin kalp tutulumuna yol açmaksızın endotel fonksiyonlarını bozar.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Bruselloz kronik semptomlu hastalarda belirgin kalp tutulumuna yol açmaksızın endotel fonksiyonlarını bozar

Öz:

Objective: Brucellosis is an important infectious disease, especially in developing countries, and may involve any organ, including the cardiovascular system. This study aimed to assess cardiac and endothelial functions in brucellosis patients. Methods: Seventy-three patients with brucellosis and seventy-five healthy volunteers from Turkey were enrolled between 2011 and 2013 in this cross-sectional study. Diagnosis was established by the Rose-Bengal test, positive Brucella standart tube agglutination test, and Coombs STA and/or isolation Brucella species from blood. Cases were divided into three groups: Group I; acute brucellosis, Group II; subacute brucellosis, and Group III; chronic brucellosis. Healthy individuals comprised Group IV. All patients underwent transthoracic echocardiogra- phy and brachial artery flow-mediated dilatation (FMD) test. Results: Groups I to IV comprised 35, 18, and 20 patients, and 75 controls respectively. The most frequent symptoms were arthralgia (82%), fever (92%), and fatigue (97%). Echocardiography revealed no difference among the 4 groups regarding left ventricular systolic and diastolic functions and valvular functions. Brachial artery diameter after hyperemia was significantly different among the groups (p=0.002). Post hoc test showed Group III to have significantly lower brachial artery diameter after hyperemia compared to other groups (p=0.02, p=0.004 and p=0.001, respectively). FMD was also significantly lower in Group III compared to Groups I, II and IV (p<0.001 for each). Conclusion: Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Gürsoy M, DEMİRTAŞ H, TURSUN İ, ALPUA M, HAYKIR SOLAY A, ÇOBANLI TOKAT M, ERCAN G, GÜRSOY S, Kalçık M, KARAKOYUN S, Özkan M (2015). Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. , 242 - 249.
Chicago	Gürsoy Mustafa Ozan,DEMİRTAŞ Hale,TURSUN İrfan,ALPUA Mehmet,HAYKIR SOLAY Aslı,ÇOBANLI TOKAT Müge,ERCAN Gülten,GÜRSOY Semra,Kalçık Macit,KARAKOYUN Sülayman,Özkan Mehmet Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. (2015): 242 - 249.
MLA	Gürsoy Mustafa Ozan,DEMİRTAŞ Hale,TURSUN İrfan,ALPUA Mehmet,HAYKIR SOLAY Aslı,ÇOBANLI TOKAT Müge,ERCAN Gülten,GÜRSOY Semra,Kalçık Macit,KARAKOYUN Sülayman,Özkan Mehmet Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. , 2015, ss.242 - 249.
AMA	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. . 2015; 242 - 249.
Vancouver	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. . 2015; 242 - 249.
IEEE	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M "Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement." , ss.242 - 249, 2015.
ISNAD	Gürsoy, Mustafa Ozan vd. "Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement". (2015), 242-249.

APA	Gürsoy M, DEMİRTAŞ H, TURSUN İ, ALPUA M, HAYKIR SOLAY A, ÇOBANLI TOKAT M, ERCAN G, GÜRSOY S, Kalçık M, KARAKOYUN S, Özkan M (2015). Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Türk Kardiyoloji Derneği Arşivi, 43(3), 242 - 249.
Chicago	Gürsoy Mustafa Ozan,DEMİRTAŞ Hale,TURSUN İrfan,ALPUA Mehmet,HAYKIR SOLAY Aslı,ÇOBANLI TOKAT Müge,ERCAN Gülten,GÜRSOY Semra,Kalçık Macit,KARAKOYUN Sülayman,Özkan Mehmet Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Türk Kardiyoloji Derneği Arşivi 43, no.3 (2015): 242 - 249.
MLA	Gürsoy Mustafa Ozan,DEMİRTAŞ Hale,TURSUN İrfan,ALPUA Mehmet,HAYKIR SOLAY Aslı,ÇOBANLI TOKAT Müge,ERCAN Gülten,GÜRSOY Semra,Kalçık Macit,KARAKOYUN Sülayman,Özkan Mehmet Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Türk Kardiyoloji Derneği Arşivi, vol.43, no.3, 2015, ss.242 - 249.
AMA	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Türk Kardiyoloji Derneği Arşivi. 2015; 43(3): 242 - 249.
Vancouver	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Türk Kardiyoloji Derneği Arşivi. 2015; 43(3): 242 - 249.
IEEE	Gürsoy M,DEMİRTAŞ H,TURSUN İ,ALPUA M,HAYKIR SOLAY A,ÇOBANLI TOKAT M,ERCAN G,GÜRSOY S,Kalçık M,KARAKOYUN S,Özkan M "Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement." Türk Kardiyoloji Derneği Arşivi, 43, ss.242 - 249, 2015.
ISNAD	Gürsoy, Mustafa Ozan vd. "Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement". Türk Kardiyoloji Derneği Arşivi 43/3 (2015), 242-249.