The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure

Kaya, Hasan; TOPRAK, Nizamettin; alan, sait; YILDIZ, Abdulkadir; POLAT, Nihat; ACET, Halit; BILIK, MEHMET ZIHNI; IŞIK, Mehmet Ali; DEMİR, Muhammet; AYDIN, MESUT

The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure

Nihat POLAT, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Abdulkadir YILDIZ, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mehmet Zihni BİLİK, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mesut AYDIN, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Halit ACET, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Hasan KAYA, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Muhammet DEMİR, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mehmet Ali IŞIK, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Sait ALAN, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Nizamettin TOPRAK (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Türk Kardiyoloji Derneği Arşivi

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Yıl: 2015 Cilt: 43 Sayı: 2 Sayfa Aralığı: 157 - 165 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure

Öz:

Amaç:Kalp yetersizliğinde bakılan çeşitli hemogram parametrelerinin prognostik önemi olduğu bilinmektedir. Bu çalışmada bu parametrelerden hangilerinin akut dekompanse kalp yetersizliği (ADKY) olan hastalarda 1 yıllık tüm nedenlere bağlı ölümü öngörmede yararlı olduğunu araştırmayı amaçladık. Çalışma planı:Eylül 2012 ile Mart 2013 tarihleri arasında ADKY tanısıyla hastanemize yatırılan ve ejeksiyon fraksiyonu ≤%40, semptom ve konjesyon bulgusu olan ardışık hastalar geriye dönük olarak çalışmaya alındı. Bir yıl içinde ölüm gözlenen ve gözlenmeyen olarak hastalar iki gruba ayrıldı. Bulgular:Çalışmaya 119 hasta (ortalama yaş 67±14 yıl; %55 erkek) dahil edildi. Bir yıl sonunda hastaların %29unun öldüğü saptandı. Ölüm gözlenen grupta hemoglobin, hemotokrit değeri ile trombosit, bazofil ve lenfosit sayısının anlamlı olarak düşük, eritrosit dağılım genişliğinin (EDG) anlamlı olarak yüksek olduğu saptandı. Nötrofil, monosit ve eozinofil sayılarını iki grupta benzer bulduk. Bunun yanında hesaplanmış glomerül filtrasyon hızı (hGFH) düşüklüğü ve anjiyotensin-dünüştürücü enzim inhibitörü/anjiyootensin reseptör blokeri (ADEİ/ ARB) kullanmama 1 yıllık ölümle ilişkili bulundu. Tek değişkenli regresyon analizinde, yaş, hipertansiyon, sağ ventrikül çapı, hGFH, ADEİ/ARB tedavisi, hemoglobin, EDG değeri ile trombosit, lökosit, nötrofil, lenfosit, bazofil, eozinofil ve monosit sayısı anlamlı bulundu. Çok değişkenli regresyon modelinde, 1 yıllık mortalite ile ilişkili bağımsız risk faktörleri olarak lenfosit, trombosit sayısı ve hemoglobin değeri düşüklüğü ile çıkış tedavisinde ACEİ/ARB tedavisi kullanmama parametreleri saptandı (p<0.05). Sonuç:Hemogram parametrelerinden lenfosit ve trombosit sayısı ile hemoglobin değeri ADKY olan hastalarda tüm nedenlere bağlı 1 yıllık mortaliteyi ön görmede basit, ucuz ve kolay ulaşılabilir bir parametre olarak kullanılabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Akut dekompanse sistolik kalp yetersizliği olan hastaların risk sınıflamasında hemogram parametrelerinin önemi

Öz:

Objectives: In patients with heart failure, a variety of hemo- gram parameters are known to be of prognostic significance. This study aimed to investigate which of these parameters is/ are useful in predicting one-year all-cause mortality in patients with acute decompensated heart failure (ADHF). Study design: Patients who were hospitalized between Sep- tember 2012-March 2013 in our hospital with systolic-ADHF with ejection fraction ≤40%, symptoms, and findings of conges- tion were enrolled retrospectively in the study. The study popu- lation was divided into two groups based on one-year-mortality. Results: 119 patients with ADHF (mean-age 67±14 years; 55% male) were enrolled in the study. One-year-mortality oc- curred in 29% of patients. Hemoglobin levels, platelet, basophil and lymphocyte counts were significantly lower, while red-cell distribution width (RDW) was found to be significantly higher in the one-year-mortality group. Neutrophil, monocyte, and eo- sinophil counts were similar in the two groups. Furthermore, lower estimated glomerular-filtration-rate (eGFR) and unused angiotensin-converting enzyme inhibitors/angiotensin recep- tor blockers (ACEI/ARB) were associated with mortality. Age, presence of hypertension, right-ventricular diameter, eGFR, ACE/ARB treatment, hemoglobin levels, RDW and platelet, leukocyte, lymphocyte, basophil, neutrophil, monocyte, and eosinophil-counts were found to have prognostic significance in univariate analysis. In multivariate analysis, decreased plate- let, lymphocyte-counts and hemoglobin level on admission and unused ACE/ARB treatment at discharge (p<0.05) were found to be independent factors predicting one-year-mortality. Conclusion: Among hematological indices; hemoglobin level, platelet and lymphocyte counts are readily available, useful and inexpensive markers for the prediction of one-year all- cause mortality in ADHF patients.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	POLAT N, YILDIZ A, BILIK M, AYDIN M, ACET H, Kaya H, DEMİR M, IŞIK M, alan s, TOPRAK N (2015). The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. , 157 - 165.
Chicago	POLAT Nihat,YILDIZ Abdulkadir,BILIK MEHMET ZIHNI,AYDIN MESUT,ACET Halit,Kaya Hasan,DEMİR Muhammet,IŞIK Mehmet Ali,alan sait,TOPRAK Nizamettin The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. (2015): 157 - 165.
MLA	POLAT Nihat,YILDIZ Abdulkadir,BILIK MEHMET ZIHNI,AYDIN MESUT,ACET Halit,Kaya Hasan,DEMİR Muhammet,IŞIK Mehmet Ali,alan sait,TOPRAK Nizamettin The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. , 2015, ss.157 - 165.
AMA	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. . 2015; 157 - 165.
Vancouver	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. . 2015; 157 - 165.
IEEE	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N "The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure." , ss.157 - 165, 2015.
ISNAD	POLAT, Nihat vd. "The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure". (2015), 157-165.

APA	POLAT N, YILDIZ A, BILIK M, AYDIN M, ACET H, Kaya H, DEMİR M, IŞIK M, alan s, TOPRAK N (2015). The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Türk Kardiyoloji Derneği Arşivi, 43(2), 157 - 165.
Chicago	POLAT Nihat,YILDIZ Abdulkadir,BILIK MEHMET ZIHNI,AYDIN MESUT,ACET Halit,Kaya Hasan,DEMİR Muhammet,IŞIK Mehmet Ali,alan sait,TOPRAK Nizamettin The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Türk Kardiyoloji Derneği Arşivi 43, no.2 (2015): 157 - 165.
MLA	POLAT Nihat,YILDIZ Abdulkadir,BILIK MEHMET ZIHNI,AYDIN MESUT,ACET Halit,Kaya Hasan,DEMİR Muhammet,IŞIK Mehmet Ali,alan sait,TOPRAK Nizamettin The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Türk Kardiyoloji Derneği Arşivi, vol.43, no.2, 2015, ss.157 - 165.
AMA	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Türk Kardiyoloji Derneği Arşivi. 2015; 43(2): 157 - 165.
Vancouver	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure. Türk Kardiyoloji Derneği Arşivi. 2015; 43(2): 157 - 165.
IEEE	POLAT N,YILDIZ A,BILIK M,AYDIN M,ACET H,Kaya H,DEMİR M,IŞIK M,alan s,TOPRAK N "The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure." Türk Kardiyoloji Derneği Arşivi, 43, ss.157 - 165, 2015.
ISNAD	POLAT, Nihat vd. "The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure". Türk Kardiyoloji Derneği Arşivi 43/2 (2015), 157-165.