Yıl: 2015 Cilt: 54 Sayı: 2 Sayfa Aralığı: 101 - 105 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri

Öz:
Fare blastokistindeki üç germ tabakasının oluşumu, hücrelerin gelişim sürecinin erken dönemindeki davranışlarını,hangi iç ve dış etkenlerin bu süreçte rol oynadığı ve bunlar arasındaki etkileşimleri çalışmak için önemli bir modelsistemi sağlamaktadır. Stabi l polarize dış epitelin oluşmasıyla birlikte, erken yarıklanma aşamasının iç ve dışhücreleri arasındaki sinyal farklılıkları iç hücre kitlesi (ICM), embriyoblast ve trofoektodermin kurulmasına yol açar.Embriyonik gelişim aşamalarında gerçekleşen hücre polaritesi, hücre pozisyonu, lokal mikroçevre etkileri,transkripsiyonel faktörler ve bunların karşılıklı etkileşimlerini içeren süreçler hücre kaderinin belirlenmesinde roloynamaktadır. Bu süre içerisinde fare gelişiminin yavaş ilerlemesi, kültür embriyo y eteneği, canlı hücre görüntülemearaçlarının geliştirilmesi ve gen ekspresyonlarını modifiye edebilme yeteneği bu süreçlerin aydınlatılabilmesinisağlamaktadır.
Anahtar Kelime:

Konular: Biyoloji Hücre ve Doku Mühendisliği

Transcriptional networks and cell signals in embryonic development

Öz:
The formation of the three lineages of the mouse blastocyst provides an important model system to study behavior ofcells in the early stage of the development process, internal and external factors which play a role in this process andthe interaction between them. With the establishment of a stable polarized outer epithelium, the signal differencesbetween the inner and outer cells of the early cleavage stages lead to the establishment of the inner cell mass(embryoblast) and the trophectoderm. Events in the stages of embryonic development including cell polarity, cellposition, effects of local microenvironment, transcriptional factors and their interaction processes are involved indetermining cell fate. The slow pace of development of the mouse during this time, the ability to culture embryos, thedevelopment of tools for live cell imaging and the ability to modify the expression of genes that enable the elucidationof the process.
Anahtar Kelime:

Konular: Biyoloji Hücre ve Doku Mühendisliği
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA AÇIKGÖZ E, Aktug H (2015). Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. , 101 - 105.
Chicago AÇIKGÖZ Eda,Aktug Huseyin Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. (2015): 101 - 105.
MLA AÇIKGÖZ Eda,Aktug Huseyin Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. , 2015, ss.101 - 105.
AMA AÇIKGÖZ E,Aktug H Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. . 2015; 101 - 105.
Vancouver AÇIKGÖZ E,Aktug H Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. . 2015; 101 - 105.
IEEE AÇIKGÖZ E,Aktug H "Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri." , ss.101 - 105, 2015.
ISNAD AÇIKGÖZ, Eda - Aktug, Huseyin. "Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri". (2015), 101-105.
APA AÇIKGÖZ E, Aktug H (2015). Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. Ege Tıp Dergisi, 54(2), 101 - 105.
Chicago AÇIKGÖZ Eda,Aktug Huseyin Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. Ege Tıp Dergisi 54, no.2 (2015): 101 - 105.
MLA AÇIKGÖZ Eda,Aktug Huseyin Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. Ege Tıp Dergisi, vol.54, no.2, 2015, ss.101 - 105.
AMA AÇIKGÖZ E,Aktug H Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. Ege Tıp Dergisi. 2015; 54(2): 101 - 105.
Vancouver AÇIKGÖZ E,Aktug H Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri. Ege Tıp Dergisi. 2015; 54(2): 101 - 105.
IEEE AÇIKGÖZ E,Aktug H "Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri." Ege Tıp Dergisi, 54, ss.101 - 105, 2015.
ISNAD AÇIKGÖZ, Eda - Aktug, Huseyin. "Embriyoner gelişimde transkripsiyonel ağlar ve hücre sinyalleri". Ege Tıp Dergisi 54/2 (2015), 101-105.