Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency

Atac, Gokce; Çandar, Tuba; Özdemir, Sedat; EZERARSLAN, Hande; KOCATÜRK, Sinan; DEMİRTAŞ, Selda

Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency

Hande EZERARSLAN, (Ufuk Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)

Tuba ÇANDAR, (Ufuk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Sedat ÖZDEMİR, (Ufuk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Gökçe Kaan ATAÇ, (Ufuk Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye)

Sinan KOCATÜRK, (Ufuk Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)

Selda DEMİRTAŞ (Ufuk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Türk Otolarengoloji Arşivi

0 0

Yıl: 2014 Cilt: 52 Sayı: 4 Sayfa Aralığı: 126 - 130 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency

Öz:

Amaç: Vertebrobaziler yetmezlik (VBY) vertebral arterve dallarında oluşan hemodinamik değişiklikler sonu- cunda akım hacminin azalması ile oluşan klinik tablo- dur. Bu çalışmanın amacı baş dönmesi şikayeti ile baş- vuran ve VBY saptanan hastaların işitme eşiklerinin veserum apelin değerlerinin belirlenmesidir. Yöntemler: Çalışmaya baş dönmesi şikayeti ile başvuranhastalar dahil edildi. Bilateral karotis ve vertebral arter- lerin renkli Doppler ultrason incelemeleri yapıldı. Has- talar VBY tanısı alan ve almayan olarak 2 gruba ayrıldı.Çalışmaya alınan kişilere 250-8000 Hertz (Hz) frekans- lar arasında saf ses odyometrisi, apelin, rutin biyokimyaparametreleri, tam kan sayımı ve C-reaktif protein öl- çümleri yapıldı. Bulgular: Çalışmaya VBY tespit edilen 38 (%47 kadın;yaş ortalaması: 57.6±9.3) hasta ve VBY tespit edilme- yen 24 (%50 kadın; yaş ortalaması: 57.0±10.1) hastaalındı. VBY olan grupta işitme eşiklerinin sadece solkulakta 500 Hz frekansı hariç diğer tüm frekanslarda yükseldiği görüldü. Ancak iki grup arasında apelin dü-zeyleri bakımından istatiksel olarak anlamlı farklılıktespit edilmedi.Sonuç: Bu çalışmada VBY olan hastalarda işitme tes-tinde saptanan anormallikler belirlenmiştir. Angiogene-zis, sıvı hemostazı ve kardiyovasküler hemodinamininsağlanmasında görev aldığı gösterilen apelin değerinin;VBYde vertebral arterlerdeki akım volümlerindeki asi-metrinin bu baziller arter disfonksiyonu yaratabileceğihipotezinden yola çıkılarak VBYde yükselebileceği dü-şünülmüştü. Bununla birlikte her iki grup apelin seviye-leri arasında anlamlı bir fark bulunamamıştır. Bu durumise çalışmaya dahil edilen hastalarda ciddi düzeyde he-modinami bozukluğu ve ateroskleroz olmaması ile iliş-kilendirilmiştir.

Anahtar Kelime:

Konular: Kulak, Burun, Boğaz

Vertebrobaziler yetmezlik tespit edilen hastalarda işitme eşikleri ve serum apelin düzeyleri

Öz:

Objective: Vertebrobasilar insufciency (VBI) is a clini- cal entity that results from the decrease in fow volumesdue to hemodynamic changes in the vertebral artery andits branches. Herein, we aimed to investigate the hearingthresholds and serum apelin levels in VBI patients whowere admitted to our clinics with vertigo. Methods: Patients who were admitted to our clinicswith vertigo were included in our study. Tey underwentbilateral carotid and vertebral artery color Doppler ul- trason investigation to determine VBI. Ten, they weregrouped into two groups: having VBI or not. Pure toneaudiometer tests between 2500-8000 Hertz (Hz) wereapplied, and plasma levels of apelin, routine biochem- istry parameters, and levels of C-reactive protein werestudied in these patients. Results: Tirty-eight (47% women, mean age 57.6±9.3)patients with VBI and 24 controls (50% women, mean age 57.0±10.1) were included. In patients with VBI,hearing thresholds were higher in the left ear exceptat the 500 Hz frequency. Serum apelin levels were notstatistically diferent between the 2 groups.Conclusion: In this study, several abnormalities inhearing tests were determined in VBI patients. Tehypothesis was that basilar artery dysfunction causedby asymmetry of vertebral artery fow volumes in VBImight increase apelin levels, which have functions in an-giogenesis, hemostasis, and cardiovascular hemodynam-ics. However, we could not fnd a signifcant diferencein apelin levels between the 2 groups. Tis result wasthought to be due to the absence of severe hemodynamicabnormalities and atherosclerosis in the study groups.

Anahtar Kelime:

Konular: Kulak, Burun, Boğaz

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Nakagawa T, Yamane H, Nakai Y, Shigeta T, Takashima T. Evalua- tion of the vertebrobasilar arterial system by magnetic resonance an- giography in the diagnosis of the vertebrobasilar insuficiency. Acta Otolaryngol 1998; 538: 54-7. [CrossRef]
2. Liu Y, Song CY, Wu SS, Liang QH, Yuan LQ, Liao EY. Novel adipokines and bone metabolism. Int J Endocrinol 2013; 2013: 895045. [CrossRef]
3. Wozniak S, Gee L, Wachtel M, Frezza E. Adipose Tissue: Te New Endocrin Organ A Review Article. Digestive Diseases and Sciences 2009; 54: 1847-56. [CrossRef]
4. Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine Pharmacology & Terapeutics 2005; 107: 198-211. [CrossRef]
5. Lee DK, George, S.R., ODowd, B.F. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol Sci 2006; 27: 190-4. [CrossRef]
6. Bendick PJ, Glover JL. Hemodynamic evaluation of vertebral arteries by duplex ultrasound. Surg Clin North Am 1990; 70: 235-44.
7. Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E; NHS Research and Development Health Technology Assessment Caro- tid Stenosis Imaging Group. Noninvasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 2006; 367: 1503-12. [CrossRef]
8. Hong JM, Chung CS, Bang OY, Yong SW, Joo IS, Huh K. Verteb- ral artery dominance contributes to basilar artery curvature and pe- ri-vertebrobasilar junctional infarcts. J Neurol Neurosurg Psychiatry 2009; 80: 1087-92. [CrossRef]
9. Bartels E, Knauth M, Liebetanz D, Paulus W. Traumatic dissection of the vertebral artery: value of sonographic diagnostics. Cerebro- vasc Dis 2006; 22: 209-13. [CrossRef]
10. Society of Atherosclerosis Imaging and Prevention Developed in collaboration with the International Atherosclerosis Society. App- ropriate use criteria for carotid intima media thickness testing. At- herosclerosis 2011; 214: 43-6. [CrossRef]
11. Pirodda A, Ferri GG, Modugno GC, Borghi C. Systemic Hypoten- sion and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects. Arch Otolaryngol Head Neck Surg 2001; 127: 1049-52. [CrossRef]
12. Suckfull M, Zacharias S, Mees K. Exploratory analysis of risk factors of acute inner ear dysfunction. Laryngorhinootologie 1999; 78: 4-8.
13. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Win- born KY, et al. Pharmacological and immunohistochemical chara- cterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 2003; 84: 1162-72. [CrossRef]
14. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. Characterization of apelin, the ligand for the APJ receptor. J Neuro- chem 2000; 74: 34-41. [CrossRef]
15. Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, et al. Te novel peptide apelin lowers blod presure via a nitric oxide-dependent mechanism. Regulatory Peptides 2001; 99: 87-92. [CrossRef]
16. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med 1994; 236: 567-73. [CrossRef]
17. Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (At- herosclerosis Risk In Communities) study. J Am Coll Cardiol 2010; 55: 1600-7. [CrossRef]
18. Kadoglou NP, Sailer N, Moumtzouoglou A, Kapelouzou A, Gera- simidis T, Kostakis A, et al. Adipokines: a novel link between adi- posity and carotid plaque vulnerability. Eur J Clin Invest 2012; 42: 1278-86. [CrossRef]

APA	EZERARSLAN H, Çandar T, Özdemir S, Atac G, KOCATÜRK S, DEMİRTAŞ S (2014). Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. , 126 - 130.
Chicago	EZERARSLAN Hande,Çandar Tuba,Özdemir Sedat,Atac Gokce,KOCATÜRK Sinan,DEMİRTAŞ Selda Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. (2014): 126 - 130.
MLA	EZERARSLAN Hande,Çandar Tuba,Özdemir Sedat,Atac Gokce,KOCATÜRK Sinan,DEMİRTAŞ Selda Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. , 2014, ss.126 - 130.
AMA	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. . 2014; 126 - 130.
Vancouver	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. . 2014; 126 - 130.
IEEE	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S "Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency." , ss.126 - 130, 2014.
ISNAD	EZERARSLAN, Hande vd. "Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency". (2014), 126-130.

APA	EZERARSLAN H, Çandar T, Özdemir S, Atac G, KOCATÜRK S, DEMİRTAŞ S (2014). Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. Türk Otolarengoloji Arşivi, 52(4), 126 - 130.
Chicago	EZERARSLAN Hande,Çandar Tuba,Özdemir Sedat,Atac Gokce,KOCATÜRK Sinan,DEMİRTAŞ Selda Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. Türk Otolarengoloji Arşivi 52, no.4 (2014): 126 - 130.
MLA	EZERARSLAN Hande,Çandar Tuba,Özdemir Sedat,Atac Gokce,KOCATÜRK Sinan,DEMİRTAŞ Selda Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. Türk Otolarengoloji Arşivi, vol.52, no.4, 2014, ss.126 - 130.
AMA	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. Türk Otolarengoloji Arşivi. 2014; 52(4): 126 - 130.
Vancouver	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency. Türk Otolarengoloji Arşivi. 2014; 52(4): 126 - 130.
IEEE	EZERARSLAN H,Çandar T,Özdemir S,Atac G,KOCATÜRK S,DEMİRTAŞ S "Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency." Türk Otolarengoloji Arşivi, 52, ss.126 - 130, 2014.
ISNAD	EZERARSLAN, Hande vd. "Hearing tresholds and serum apelin levels in patients with vertebrobasilar ınsufciency". Türk Otolarengoloji Arşivi 52/4 (2014), 126-130.