Yakup CANITEZ
(Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Allerji Bilim Dalı, Bursa, Türkiye)
Hülya EFE POYRAZ
(Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Allerji Bilim Dalı, Bursa, Türkiye)
Nihat SAPAN
(Uludağ Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Allerji Bilim Dalı, Bursa, Türkiye)
Yıl: 2015Cilt: 9Sayı: 2ISSN: 1307-4490 / 2148-3566Sayfa Aralığı: 147 - 151Türkçe

89 2
Karbamazepine bağlı dress sendromu; Nadir görülen bir ilaç hipersensitivite reaksiyonu
DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) sendromu, ateş, deri döküntüsü, lenfadenopati ve iç organ tutulumuyla karakterize, yaşamı tehdit edebilen ve çocukluk çağında nadir görülen bir gecikmiş tip ilaç hiper- sensitivite reaksiyonudur. Beş yaşında kız hasta, epilepsi tanısı ile karbamazepin tedavisi başlandıktan bir ay sonra, vücudunda yaygın döküntü ve ateş yakınmalarıyla başvurdu. Fizik muayenede ateş, deride yaygın makülopapüler döküntü, submandibular bölgede bilateral lenfadenopati ve hepatomegali mevcuttu. Hastaya klinik bulgular ve laboratuvar incelemeleri (atipik lenfositlerin varlığı, eozinofli ve hipertransaminazemi) sonucun - da DRESS sendromu tanısı konuldu ve destek tedavisi, sistemik kortikosteroid ve intravenöz immünglobulin (İVİG) ile tedavi edildi. İlaç kullanma öyküsü, ateş, deri döküntüsü, lenfadenopati ve iç organ tutulumu bulguları olan çocuklarda ayırıcı tanıda DRESS sendromu göz önünde tutulmalıdır. Tedavide temel prensipler, hastalığa erken tanı konulması, neden olduğu düşünülen ilacın kesilmesi ve destek tedavisidir. Özellikle ciddi olgularda sistemik kortikosteroid ve İVİG tedavisi kullanıl - ması önerilmektedir.
Fen > Tıp > Alerji
Fen > Tıp > Pediatri
Dergititle.paper.fact_presentationErişime Açık
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