The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

TUNÇOK, YESIM; BÜYÜKDELİGÖZ, Müjgan; ORANSAY, Kubilay; KALKAN, Şule; HOCAOĞLU AKSAY, NİL

The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

Müjgan BÜYÜKDELİGÖZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İzmir, Türkiye)

NİL HOCAOĞLU AKSAY, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İzmir, Türkiye)

Kubilay ORANSAY, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İzmir, Türkiye)

Yeşim TUNÇOK, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İzmir, Türkiye)

Şule KALKAN (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İzmir, Türkiye)

Balkan Medical Journal

1 0

Yıl: 2015 Cilt: 32 Sayı: 3 Sayfa Aralığı: 303 - 308 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

Öz:

Background: Citalopram is a selective serotonin re- uptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QTinterval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulatingadenosine A1 receptors without affecting the release ofadenosine. Aims: We examined the effects of adenosine receptorantagonists in reversing the cardiovascular toxic effectsinduced by citalopram in rats. Study Design: Animal experimentation. Methods: Rats were divided into three groups ran- domly (n=7 for each group). Sodium cromoglycate (20mg/kg) was administered to all rats to inhibit adenosineA3 receptor mast cell activation. Citalopram toxicitywas achieved by citalopram infusion (4 mg/kg/min) for20 minutes. After citalopram infusion, in the controlgroup (Group 1), rats were given an infusion of dextrose solution for 60 minutes. In treatment groups, theselective adenosine A1 antagonist DPCPX (Group 2,8-cyclopentyl-1,3-dipropylxanthine, 20 μg/kg/min) orthe selective A2a antagonist CSC (Group 3, 8-(3-chlo- rostyryl)caffeine, 24 μg/kg/min) was infused for 60 minutes. Mean arterial pressure (MAP), heart rate(HR), QRS duration and QT interval measurementswere followed during the experiment period. Statistical analysis was performed by ANOVA followed byTukey s multiple comparison tests.Results: Citalopram infusion reduced MAP and HRand prolonged the QT interval. It did not cause anysignificant difference in QRS duration in any group.When compared to the control group, DPCPX aftercitalopram infusion shortened the prolongation of theQT interval after 40, 50 and 60 minutes (p<0.01). DP- CPX infusion shortened the prolongation of the QTinterval at 60 minutes compared with the CSC group(p<0.05). CSC infusion shortened the prolongation ofthe QT at 60 minutes compared with the control group(p<0.05). Conclusion: DPCPX improved QT interval prolon- gation in citalopram toxicity. The results of this studyshow that mechanism of cardiovascular toxicity induced by citalopram may be related adenosine A1 receptor stimulation. Adenosine A1 receptor antagonistsmay be used for the treatment of citalopram toxicity.

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APA	BÜYÜKDELİGÖZ M, HOCAOĞLU AKSAY N, ORANSAY K, TUNÇOK Y, KALKAN Ş (2015). The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. , 303 - 308.
Chicago	BÜYÜKDELİGÖZ Müjgan,HOCAOĞLU AKSAY NİL,ORANSAY Kubilay,TUNÇOK YESIM,KALKAN Şule The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. (2015): 303 - 308.
MLA	BÜYÜKDELİGÖZ Müjgan,HOCAOĞLU AKSAY NİL,ORANSAY Kubilay,TUNÇOK YESIM,KALKAN Şule The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. , 2015, ss.303 - 308.
AMA	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. . 2015; 303 - 308.
Vancouver	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. . 2015; 303 - 308.
IEEE	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş "The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning." , ss.303 - 308, 2015.
ISNAD	BÜYÜKDELİGÖZ, Müjgan vd. "The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning". (2015), 303-308.

APA	BÜYÜKDELİGÖZ M, HOCAOĞLU AKSAY N, ORANSAY K, TUNÇOK Y, KALKAN Ş (2015). The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. Balkan Medical Journal, 32(3), 303 - 308.
Chicago	BÜYÜKDELİGÖZ Müjgan,HOCAOĞLU AKSAY NİL,ORANSAY Kubilay,TUNÇOK YESIM,KALKAN Şule The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. Balkan Medical Journal 32, no.3 (2015): 303 - 308.
MLA	BÜYÜKDELİGÖZ Müjgan,HOCAOĞLU AKSAY NİL,ORANSAY Kubilay,TUNÇOK YESIM,KALKAN Şule The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. Balkan Medical Journal, vol.32, no.3, 2015, ss.303 - 308.
AMA	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. Balkan Medical Journal. 2015; 32(3): 303 - 308.
Vancouver	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning. Balkan Medical Journal. 2015; 32(3): 303 - 308.
IEEE	BÜYÜKDELİGÖZ M,HOCAOĞLU AKSAY N,ORANSAY K,TUNÇOK Y,KALKAN Ş "The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning." Balkan Medical Journal, 32, ss.303 - 308, 2015.
ISNAD	BÜYÜKDELİGÖZ, Müjgan vd. "The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning". Balkan Medical Journal 32/3 (2015), 303-308.