Yıl: 2014 Cilt: 21 Sayı: 4 Sayfa Aralığı: 280 - 285 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors

Öz:
Amaç: Bu çalışmayla postoperatif radyoterapi uygulanan hastalarda, tümöre ve tedaviye bağlı prognostik faktörlerin, lokal ve bölgesel kontrol, genel sağkalım ve hastalıksız sağkalım üzerindeki etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Adjuvan eksternal radyoterapi ve brakiterapi uygulanan 61 endometrium kanserli hasta retrospektif olarak değerlendirilmiştir. Hastaların yaşı, tümör diferansiasyonu, tümör evresi, lenfovasküler invazyon, seroza invazyonu, myometrial invazyon, endoservikal tutulum, adneks tutulumu, lenf nodu tutulumu, sigara kullanımı, hipertansiyon ve diyabet hastalığı, hormon replasman tedavisi alıp almaması, doğum sayısı, menopoz yaşı, kemoterapi durumu, vajinal brakiterapi, radyoterapi şekli ve dozları, lokal nüks değerlendirilmiştir. Bulgular: Altmış bir hastanın 53ü (%87) endometrioid adenokarsinom, 8i (%13) ise diğer adenokarsinom (seröz, müsinöz, clear cell, mikst tip) histolojisine sahipti. Hastaların 53üne (%87) Total abdominal histerektomi+ bilateral salfingooferektomi + bilateral pelvik lenf nodu diseksiyonu (TAH+BSO+BPLND), 8 hastaya (%13) sadece TAH+BSO yapılmış. Otuz hastaya konvansiyonel, 23 hastaya ise konformal radyoterapi uygulanmıştır. Sekiz hastaya ise eksternal radyoterapi uygulanmamış sadece brakiterapi uygulaması yapılmıştır. İki yıllık genel sağkalım %93.4; 5 yıllık genel sağkalım %80.3 olarak bulunmuştur. Ortalama sağkalım 51 aydır. Hastalıksız sağkalım 2 yıllık ve 5 yıllık sırasıyla %85.2 ve %77 olarak tespit edildi. Genel sağkalım üzerine, serozal invazyon olması (p=0.034) anlamlı bulundu. Sonuç: Endometrium kanserinde postoperatif radyoterapi efektif ve güvenli bir yöntemdir.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Endometrium Kanserinde Postoperatif Radyoterapi: Tedavi Sonuçları ve Prognostik Faktörler

Öz:
Introduction and Purpose: In this study, we aim to investigate the effects of the prognostic factors related to tumour, treatment, local and regional controls, overall survival, and disease free survival in postoperative radiotherapy patients. Materials and Methods: Sixty-one patients admitted to suffering from adenocarcinom of endometrium were analyzed retrospectively following surgical operation, adjuvant radiotherapy, and brachytherapy. We evaluated the patients in trems of age, tumour differentiations, tumour stage, lymphovascular invasion, serosal invasion, myometrial invasion, endocervical invasion, adnex involvement, lymph node involvement, menopausal age, hypertension, diabetes mellitus, smoking history, parity, hormone replacement therapy, chemotherapy process, vaginal brachitherapy, the type and doses of radiotherapy and local relapses. Throughout our research, we studied how overall survival and disease-free survival are influenced by factors like age, stage, tumour differentiation, histological type, lymph node involvement, lymphovascular invasion (LVI), endocervical invasion, serosal invasion, menopausal age, hypertension, diabetes mellitus, smoking history, parity, hormone replacement therapy (HRT), operation type, depth of myometrial invasion, and adnexal involvement. Results: Fifty three patiens (87%) were exposed to total abdominal hysterectomy+bilateral saphingo oohporectomy+bilateral pelvic lymp node dissection (TAH+BSO+BPLND), while 8 patients (13%) were exposed to TAH-BSO. Thirty patients were treated by conventional methods, 23 patients were treated by conformal methods. Eight patients were treated only by brachytherapy. The five-year overall survival rate was 80.3% and disease-free survival rate was found to be 77%. Two year overall survival rate was 93.4% and disease-free survival rate was 85.2%. It was noticed that serosal invasion (p=0.034) affect overall survival. Conclusion: Postoperative radiation therapy is an effective and safe treatment option in endometrium cancer.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA temelli ö, GÜROCAK S, KEKİLLİ E, EKİCİ K (2014). Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. , 280 - 285.
Chicago temelli öztun,GÜROCAK SIMAY,KEKİLLİ Ersoy,EKİCİ Kemal Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. (2014): 280 - 285.
MLA temelli öztun,GÜROCAK SIMAY,KEKİLLİ Ersoy,EKİCİ Kemal Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. , 2014, ss.280 - 285.
AMA temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. . 2014; 280 - 285.
Vancouver temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. . 2014; 280 - 285.
IEEE temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K "Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors." , ss.280 - 285, 2014.
ISNAD temelli, öztun vd. "Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors". (2014), 280-285.
APA temelli ö, GÜROCAK S, KEKİLLİ E, EKİCİ K (2014). Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 21(4), 280 - 285.
Chicago temelli öztun,GÜROCAK SIMAY,KEKİLLİ Ersoy,EKİCİ Kemal Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 21, no.4 (2014): 280 - 285.
MLA temelli öztun,GÜROCAK SIMAY,KEKİLLİ Ersoy,EKİCİ Kemal Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.21, no.4, 2014, ss.280 - 285.
AMA temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2014; 21(4): 280 - 285.
Vancouver temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2014; 21(4): 280 - 285.
IEEE temelli ö,GÜROCAK S,KEKİLLİ E,EKİCİ K "Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 21, ss.280 - 285, 2014.
ISNAD temelli, öztun vd. "Postoperative Radiotherapy for Endometrial Cancer: Treatment Results and Prognostic Factors". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 21/4 (2014), 280-285.