Yıl: 2014 Cilt: 5 Sayı: 4 Sayfa Aralığı: 312 - 315 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?

Öz:
Amaç: Kontrast madde nefropatisi (KMN), kontrast madde (KM) verdiktensonra böbrek fonksiyonlarındaki akut azalma olarak tanımlanır. Biz bu deneysel rat çalışmasında izotonik sodyum klorürün bolus IV (intravenöz) infüzyonunun KMN gelişmesini önlemedeki etkinliğini araştırmayı amaçladık. Gereçve Yöntem: Çalışmamızda 28 adet Wistar albino cinsi dişi rat yedişerli dörtgruba ayrıldı. Gruplar şöyle tanımlandı: KM veya IV sıvı verilmeyen (Grup I),sadece KM (Grup II), önce KM hemen ardından bolus IV sıvı, (Grup III) ve öncebolus IV sıvı ve sonrasında KM (Grup IV) uygulandı. Daha sonra serum kreatinin (Kr) değerleri için kan örnekleri alındı ve bazal değerler ve 72.saat değerleri olmak üzere iki kere çalışıldı. Ratlardan 72. saat serum Kr değerlerinde,bazal değere göre %25den fazla yükselme gözlenenlerde KMN gelişmiş olduğu kabul edildi. Bulgular: Çalışma boyunca rat kaybı olmadı. İkinci grupta dörtratta, dördüncü grupta ise bir ratta KMN gelişti. Üçüncü gün serum Kr ortalamaları değerleri karşılaştırıldığında, birinci grup ve dördüncü grupta anlamlıfark gözlenmezken, ikinci ve üçüncü grupta anlamlı fark gözlendi. Tüm gruplarda üçüncü gün serum Kr değerleri kıyaslandığında aralarında anlamlı farkgözlendi ve bu farklılığın ikinci gruptan kaynaklandığı bulundu. Tartışma: Yaptığımız hayvan deneyi çalışması; IV KM kullanmadan önce veya kullandıktanhemen sonra bolus izotonik sıvı kullanılmasının KMN gelişmesini azaltmadabaşarılı olduğu gösterildi.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Bolus İzotonik Salin İnfüzyonu Ratlarda Kontrast Nefropatisini Önler mi?

Öz:
Aim: Contrast-induced nephropathy (CIN) is defined as acute impairment inrenal functions following the use of contrast agents. We aimed to search theeffect of IV bolus infusion of isotonic sodium cloride on the developmentof CIN in an experimental rats model. Material and Method: In our study,28 Wistar albino female rats were seperated into four groups with sevenrats in each. Groups were defined as: Neither contrast agent nor fluid wasgiven (group 1), only contrast agent (Group II), initial contrast agent andthen IV fluid (Group III) and initial IV fluid and then contrast agent (GroupIV). Blood samples for serum creatinin (Cr) values were obtained twice asat the baseline and then 72 hours later. In serum creatinin levels, morethan 25% increases after 72-hour s levels according to basal values wereaccepted as CIN. Results: In our study, no rat had died during the study period.CIN was developed in four rats in the Group II and in one rat in the GroupIV. When comparing the mean values of serum Cr; there was no significantdifference between the Group I and the Group IV while there was a significantdifference between the Group II and the Group III. When comparing the serumcreatinine levels between all groups after 72 hours, serum creatinine levelswere significantly lower than the other. Discussion: Our animal study resultsshowed that bolus isotonic fluid infusion either before contrast agent or aftercontrast agent is effective to decrease CIN development.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Güllüpınar B, YANTURALI S, ÇOLAK ORAY N, SARIHAN A, TOPAÇOĞLU H (2014). Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. , 312 - 315.
Chicago Güllüpınar Birdal,YANTURALI Sedat,ÇOLAK ORAY Neşe,SARIHAN AYDIN,TOPAÇOĞLU Hakan Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. (2014): 312 - 315.
MLA Güllüpınar Birdal,YANTURALI Sedat,ÇOLAK ORAY Neşe,SARIHAN AYDIN,TOPAÇOĞLU Hakan Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. , 2014, ss.312 - 315.
AMA Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. . 2014; 312 - 315.
Vancouver Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. . 2014; 312 - 315.
IEEE Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H "Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?." , ss.312 - 315, 2014.
ISNAD Güllüpınar, Birdal vd. "Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?". (2014), 312-315.
APA Güllüpınar B, YANTURALI S, ÇOLAK ORAY N, SARIHAN A, TOPAÇOĞLU H (2014). Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. Journal of Clinical and Analytical Medicine, 5(4), 312 - 315.
Chicago Güllüpınar Birdal,YANTURALI Sedat,ÇOLAK ORAY Neşe,SARIHAN AYDIN,TOPAÇOĞLU Hakan Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. Journal of Clinical and Analytical Medicine 5, no.4 (2014): 312 - 315.
MLA Güllüpınar Birdal,YANTURALI Sedat,ÇOLAK ORAY Neşe,SARIHAN AYDIN,TOPAÇOĞLU Hakan Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. Journal of Clinical and Analytical Medicine, vol.5, no.4, 2014, ss.312 - 315.
AMA Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. Journal of Clinical and Analytical Medicine. 2014; 5(4): 312 - 315.
Vancouver Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?. Journal of Clinical and Analytical Medicine. 2014; 5(4): 312 - 315.
IEEE Güllüpınar B,YANTURALI S,ÇOLAK ORAY N,SARIHAN A,TOPAÇOĞLU H "Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?." Journal of Clinical and Analytical Medicine, 5, ss.312 - 315, 2014.
ISNAD Güllüpınar, Birdal vd. "Does Bolus Isotonic Saline Infusion Prevents Rats from Contrast Induced-Nephropathy?". Journal of Clinical and Analytical Medicine 5/4 (2014), 312-315.