KOAH ve astımda atak

Yıl: 2015 Cilt: 63 Sayı: 2 Sayfa Aralığı: 111 - 131 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

KOAH ve astımda atak

Öz:
Kronik obstrüktif akciğer hastalığı (KOAH) ve astım, ataklarla seyreden hava yollarının hastalıklarıdır. Ataklar her iki hastalıkta da hastalığın doğal seyrini etkilemektedir. KOAH atakları infeksiyonlar ve infeksiyon dışı nedenlere bağlı olarak gelişebilir. İnfeksiyon dışınedenler; başlıca çevresel faktörler (iç ve dış ortam hava kirliliği, mevsimsel değişiklikler), kardiyovasküler hastalıklar, astım-KOAHoverlap sendrom varlığı, KOAH-obstrüktif uyku apne overlap sendrom varlığı, pulmoner emboli, gastro-özefageal reflü, anksiyetedepresyon, pulmoner hipertansiyon olması gibi diğer faktörlerdir. Astım atakları, tetikleyen etkenlere maruziyet, viral infeksiyonlar, tedavinin hasta veya hekim tarafından aksatılması veya yetersiz verilmesi ile ortaya çıkar. Sigaranın bırakılması, infeksiyonların önlenmesi, uzun etkili antikolinerjik, uzun etkili β2 agonist, inhaler kortikosteroidler, fosfodiesteraz-4 inhibitörleri, mukolitikler, profilaktik antibiyotikler KOAH akut ataklarının önlenmesinde etkili olabilir. Astımda tetikleyen allerjen, viral infeksiyonlardan korunma, mesleki ajanlar, çevre kirliliğinden sakınma, komorbit hastalıkların tedavisi ile atak oranlarında azalmalar sağlanabilmektedir. Etkin tedaviler verilmesi; inhaler steroidler ve kombine tedaviler atakların önlenmesinde en etkin tedavi ajanlarıdır. Hasta eğitimi ve hasta ile işbirliği; etkin bir tedavi verilerek hastaya düzgün tedavisinin kullanımının gereği, inhaler tekniği öğretilmeli ve eline yazılı eylem planı verilerek yakınmaları başlayınca yapması gerekenler yazılarak aktarılmalıdır. KOAH ve astım atak tedavisinin temeli yoğun bir bronkodilatör tedavidir. Buna paralel olarak, atakta yangıya yönelik steroid tedavileri de, hastanın durumuna göre, devreye sokulur. Ayrıca atağa neden olan soruna (infeksiyon, hava kirliliği, emboli vb.) özgül tedavi ve uygulanmalıdır.
Anahtar Kelime:

Konular: Solunum Sistemi

Acute exacerbation in COPD and asthma

Öz:
Chronic obstructive pulmonary disease (COPD) and asthma are airway diseases with acute exacerbations. Natural course of both disease are affected by exacerbations. COPD exacerbations may be caused by infections and other causes; indoor and outdoor pollution, cardiovascular diseases, asthma-COPD overlap syndrome, COPD- obstructive sleep apnea syndrome, pulmonary embolism, gastro-oesophageal reflux, anxiety-depression, pulmonary hypertension. Exposure to triggering factors, viral infections, treatment insufficiency may cause asthma exacerbations. Smoking cessations, prevention of infections, long-acting anticholinergics, long-acting β2 agonists, inhaled corticosteroids, phosphodiesterase-4 inhibitors, mucolytics, prophilactic antibiotics can be effective on the prevention of COPD exacerbations. Asthma exacerbations may be decreased by the avoidance of allergens, viral infections, occupational exposures, airpollution, treatment of comorbid diseases. Effective treatment of asthma is required to prevent asthma exacerbations. Inhaled steroids and combined treatments are the most effective preventive therapy for exacerbations. Patient education and cooperation is an element of the preventive measures for asthma attacks. Compliance to therapy, inhalation techniques, written asthma plans are required. The essential of COPD and asthma exacerbation treatment is bronchodilator therapy. Steroids are also implemented to the therapy, targeting the inflammation. Specific treatments of the cause (infection, airpollution, pulmonary embolism etc.) should be administered.
Anahtar Kelime:

Konular: Solunum Sistemi
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Global Initiative for Chronic Obstructive Lung Disease. The Global Strategy for Diagnosis, management and Prevention of COPD (updated 2014, www.goldcopd.org).
  • 2. Caramori G, Contoli M, Marku B, Casolari P, Pauletti A, Forini G, et al. Definition and aetiology of infective exacerbations of COPD. Eur Respir Monogr 2013;60:58-67.
  • 3. Reddel HK, Taylor DR, Bateman ED Boulet LP, Boushey HA, Busse WW. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009:1;180:59-99. doi: 10.1164/rccm.200801-060ST.
  • 4. Montania D, Cavailles A, Bertoletti L, Botelhod A, Cortot A, Taillé C, et al. Adult asthma exacerbations in questions. Rev Mal Respir 2010:27:1175-94. doi: 10.1016/j.rmr.2010.10.005.
  • 5. Global Strategy for Asthma Management and Prevention. Available at: http://www.ginasthma.org/local/uploads/ files/GINA_Report_2014_Jun11.pdf, (Last accessed on july 2014).
  • 6. Hurst JR, Donaldson GC, Perera WR, Wilkinson TM, Bilello JA, Hagan GW, et al. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;174:867-74.
  • 7. Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:250-5.
  • 8. Schuetz P, Müller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev 2012;9:CD007498. doi: 10.1002/14651858.CD007498.pub2.
  • 9. Thomsen M, Ingebrigtsen TS, Marott JL, Dahl M, Lange P, Vestbo J, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013;309:2353-61.
  • 10. Polatli M, Cakir A, Cildag O, Bolaman AZ, Yenisey C, Yenicerioglu Y. Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation. J Thromb Thrombolysis 2008;26:97-102.
  • 11. Casanova C, Celli BR. Microalbuminuria as a potential novel cardiovascular biomarker in patients with COPD. Eur Respir J 2014;43:951-53. doi: 10.1183/09031936.00015614.
  • 12. Romundstad S, Naustdal T, Romundstad PR, Sorger H, Langhammer A. COPD and microalbuminuria: a 12-year follow-up study. Eur Respir J 2014;43:1042-50.
  • 13. Agusti A, Sin DD. Biomarkers in COPD. Clin Chest Med 2014;35:131-141. doi: 10.1016/j.ccm.2013.09.006.
  • 14. Hurst JR. Exacerbation phenotyping in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;184:625-26. doi: 10.1164/rccm.201106-1136ED.
  • 15. Suissa S, Dell'Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax 2012;67:957-63. doi: 10.1136/thoraxjnl-2011-201518.
  • 16. Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 2011;184:662- 71. doi: 10.1164/rccm.201104-0597OC.
  • 17. Türk Toraks Derneği Astım Tanı ve Tedavi Rehberi, Turkish Thoracic J 2014;(suppl 1) Available at Global Initiative for Chronic Obstructive Lung Disease. The Global Strategy for Diagnosis, management and Prevention of COPD (updated 2014, www.goldcopd.org): http://www.toraks. org.tr/uploadFiles/book/file/242014113315-kapak.pdf, (Last accessed on july 2014)
  • 18. BTS/SIGN British Guideline on the management of asthma. Available at: https://www.brit-thoracic.org.uk/ document-library/clinical-information/asthma/btssignguideline-on-the-management-of-asthma/ (Last accessed on july 2014).
  • 19. Expert Panel Report 3 (EPR3): Guidelines for the Diagnosis and Management of Asthma. Available at: http://www. nhlbi.nih.gov/ guidelines/asthma/asthgdln.htm. (Last accessed on july 2014).
  • 20. Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987;106:196-204.
  • 21. Siddiqi A, Sethi S. Optimizing antibiotic selection in treating COPD exacerbations. Int J Chron Obstruct Pulmon Dis 2008;3:31-44.
  • 22. Wedzicha JA, Mackay AJ, Singh R. COPD exacerbations: impact and prevention. Breathe 2013;9:434-40.
  • 23. Plaza V, Serrano J, Picado C, Sanchis J; High Risk Asthma Research Group. Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma. Eur Respir J 2002;19:846-52.
  • 24. Tattersfield AE, Postma DS, Barnes PJ, Svensson K, Bauer CA, O'Byrne PM. Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. Am J Respir Crit Care Med 1999;160:594-9.
  • 25. Nievas IF, Anand KJ. Severe acute asthma exacerbation in children: a stepwise approach for escalating therapy in a pediatric intensive care unit. J Pediatr Pharmacol Ther 2013;18:88-104. doi: 10.5863/1551-6776-18.2.88.
  • 26. Picado C. Classification of severe asthma exacerbations: a proposal. Eur Respir J 1996;9:1775-8.
  • 27. Wasserfallen JB1, Schaller MD, Feihl F, Perret CH. Sudden asphyxic asthma: a distinct entity? Am Rev Respir Dis 1990;142:108-111.
  • 28. Ayres JG, Miles JF, Barnes PJ. Brittle asthma. Thorax 1998;53:315-21.
  • 29. Alvarez GG1, Schulzer M, Jung D, Fitzgerald JM. A systematic review of risk factors associated with near-fatal and fatal asthma. Can Respir J 2005;12:265-270.
  • 30. Robin ED, Lewiston N. Unexpected, unexplained sudden death in young asthmatic subjects. Chest 1989;96:790-3.
  • 31. Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363:1128-38. doi: 10.1056/NEJMoa0909883.
  • 32. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, et al. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiolog 2011;261:274-82. doi: 10.1148/radiol.11110173.
  • 33. Wedzicha JA, Singh R, Mackay AJ. Acute COPD exacerbations. Clin Chest Med 2014;35:157-163. doi: 10.1016/j.ccm.2013.11.001.
  • 34. Mackay AJ, Donaldson GC, Patel AR, et al. Detection and severity grading of COPD exacerbations using the exacerbations of chronic pulmonary disease tool (EXACT). Eur Respir J 2014;43:735-744.
  • 35. Mackay AJ, Donaldson GC, Patel AR, Jones PW, Hurst JR, Wedzicha JA. Usefulness of the Chronic Obstructive Pulmonary Disease Assessment Test to evaluate severity of COPD exacerbations. Am J Respir Crit Care Med 2012;185:1218-24. doi: 10.1164/rccm.201110-1843OC.
  • 36. Steer J, Gibson J, Bourke SC. The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax 2012;67:970-6.
  • 37. Almagro P, Soriano JB, Cabrera FJ, Boixeda R, Alonso-Ortiz MB, Barreiro B, et al. Short-and medium - term prognosis in patinets hospitalized for COPD exacerbation. The CODEX index. Chest 2014;145:972-80.
  • 38. Sato R, Tomita K, Sano H, Ichihashi H, Yamagata S, Sano A, et al. The strategy for predicting future exacerbation of asthma using a combination of the Asthma Control Test and lung function test. J Asthma 2009;46:677-82. doi: 10.1080/02770900902972160.
  • 39. Chapman KR, Boulet LP, Rea RM, Franssen E. Suboptimal asthma control: prevalence, detection and consequences in general practice. Eur Respir J 2008;31:320-5.
  • 40. Demoly P, Gueron B, Annunziata K,et al. Update on asthma control in five European countries: results of a 2008 survey. Eur Respir Rev 2010;19:150-7. doi: 10.1183/09059180.00002110.
  • 41. Bateman ED, Reddel HK, Eriksson G, Peterson S, Ostlund O, Sears MR, et al. Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol 2010;125:600-8. doi: 10.1016/j. jaci.2009.11.033.
  • 42. Wei HH, Zhou T, Wang L, Zhang HP, Fu JJ, Wang L, et al. Current asthma control predicts future risk of asthma exacerbation: a 12-month prospective cohort study Chin Med J 2012;125:2986-93.
  • 43. Ko FW, Hui DS, Leung TF, Chu HY, Wong GW, Tung AH, et al. Evaluation of the asthma control test: A reliable determinant of disease stability and a predictor of future exacerbations. Respirology 2012;17:370-8. doi: 10.1111/j.1440-1843.2011.02105.x.
  • 44. Honkoop PJ, Taylor DR, Smith AD, Snoeck-Stroband JB, Sont JK. Early detection of asthma exacerbations by using action points in self-management plans. Eur Respir J 2013;41:53-9. doi: 10.1183/09031936.00205911.
  • 45. Stanford RH, Shah MB, D'Souza AO, Dhamane AD, Schatz M. Short-acting b-agonist use and its ability to predict future asthma-related outcomes. Ann Allergy Asthma Immunol 2012;109:403-7. doi: 10.1016/j. anai.2012.08.014.
  • 46. Buhl R, Kuna P, Peters MJ, Andersson TL, Naya IP, Peterson S, et al. The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy. Respir Res 2012;13:59. doi: 10.1186/1465-9921-13-59.
  • 47. Laforest L, Licaj I, Devouassoux G, Chatte G, Martin J, Van Ganse E. Asthma drug ratios and exacerbations: claims data from universal health coverage systems. Eur Respir J 2014;43:1378-86. doi: 10.1183/09031936.00100113.
  • 48. Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G, et al. Current evidence and future research needs for FeNO measurement in respiratory diseases. Respir Med 2014;108:830-41. doi:10.1016/j. rmed.2014.02.005.
  • 49. Zeiger RS, Schatz M, Zhang F, Crawford WW, Kaplan MS, Roth RM, et al. Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids. J Allergy Clin Immunol 2011;128:412-4. doi: 10.1016/j.jaci.2011.06.008.
  • 50. Gelb AF, Flynn Taylor C, Shinar CM, Gutierrez C, Zamel N. Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest 2006;129:1492-9.
  • 51. Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med 2000;161:64-72.
  • 52. Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, et al. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol 2005;115:720-7.
  • 53. Forno E, Celedón JC. Predicting asthma exacerbations in children. Curr Opin Pulm Med 2012;18:63-9. doi: 10.1097/MCP.0b013e32834db288.
  • 54. Zeiger RS, Yegin A, Simons FE, Haselkorn T, Rasouliyan L, Szefler SJ, et al. Evaluation of the National Heart, Lung, and Blood Institute guidelines impairment domain for classifying asthma control and predicting asthma exacerbations. Ann Allergy Asthma Immunol 2012;108:81-7. doi: 10.1016/j. anai.2011.12.001.
  • 55. Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000;55:114-20.
  • 56. Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002;57:847-52.
  • 57. Ramon MA, Gimeno-Santos E, Ferrer J Balcells E, Rodríguez E, de Batlle J, et al. Hospital admissions and exercise capacity decline in patinents with COPD. Eur Respir J 2014;43:1018-27. doi: 10.1183/09031936. 00088313.
  • 58. Piquet J, Chavaillon JM, David P, Martin F, Blanchon F, Roche N, et al. High risk patients following hospitalisation for an acute exacerbation of COPD. Eur Respir J 2013;42:946-55. doi: 10.1183/09031936.00180312.
  • 59. Soler-Cataluna JJ, Martinez-Garcia MA, Sanchez PR, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005;60:925-31.
  • 60. Donaldson GC, Hurst JR, Smith CJ, Hubbard RB, Wedzicha JA. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest 2010;137:1091-7. doi: 10.1378/chest.09-2029.
  • 61. McDonald VM, Gibson PG. Exacerbations of severe asthma. Clin Exp Allergy 2012;42:670-7. doi: 10.1111/j.1365-2222.2012.03981.x.
  • 62. Steppuhn H, Langen U, Scheidt-Nave C, Keil T. Major comorbid conditions in asthma and association with asthma-related hospitalizations and emergency department admissions in adults: results from the German national health telephone interview survey (GEDA) 2010. BMC Pulm Med 2013;13:46. doi: 10.1186/1471-2466-13-46.
  • 63. Menezes AM, Montes de Oca M, Pérez-Padilla R, PérezPadilla R, Nadeau G, Wehrmeister FC, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest 2014;145:297- 304.
  • 64. Miller MK, Lee JH, Miller DP, Wenzel SE; TENOR Study Group. Recent asthma exacerbations: a key predictor of future exacerbations. Respir Med 2007;101:481-9. 65. Calhoun WJ, Haselkorn T, Mink DR,et al. Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort. J Allergy Clin Immunol Pract 2014;2:193-200. doi: 10.1016/j.jaip.2013.11.013.
  • 66. Tough SC, Hessel PA, Ruff M, Green FH, Mitchell I, Butt JC. Features that distinguish those who die from asthma from community controls with asthma. J Asthma 1998;35:657-65.
  • 67. Kupczyk M, ten Brinke A, Sterk PJ, Bel EH, Papi A, Chanez P, et al. Frequent exacerbators a distinct phenotype of severe asthma. Clin Exp Allergy 2014;44:212-21 doi: 10.1111/cea.12179.
  • 68. Balter M, Ernst P, Watson W, et al. Asthma Worsenings Working Group. Asthma worsenings: approaches to prevention and management from the Asthma Worsenings Working Group. Can Respir J 2008;15(Suppl B):1B-19B.
  • 69. Soler N, Torres A, Ewig S, Gonzalez J, Celis R, El-Ebiary M, et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med 1998;157:1498-505.
  • 70. Sethi S, Evans N, Grant BJ, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002;347:465-71.
  • 71. Domenech A, Puig C, Martí S, Santos S, Fernández A, Calatayud L, et al. Infectious etiology of acute exacerbations in severe COPD patients. J Infection 2013;67:516-23. doi: 10.1016/j.jinf.2013.09.003.
  • 72. Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia P. Lung microbiology and exacerbations in COPD. Int J Chron Obstruct Pulmon Dis 2012;7:555– 69. doi: 10.2147/COPD.S28286.
  • 73. Patel IS, Vlahos I, Wilkinson TMA, Lloyd-Owen SJ, Donaldson GC, Wilks M, et al. Bronchiectasis, exacerbation índices, and inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170:400-7.
  • 74. Tumkaya M, Atis S, Ozge C, Delialioglu N, Polat G, Kanik A. Relationship between airway colonization, inflammation and exacerbation frequency in COPD. Respir Med 2007;101:729-37.
  • 75. Zhang M, Li Q, Zhang XY, Ding X, Zhu D, Zhou X. Relevance of lower airway bacterial colonization, airway inflammation, and pulmonary function in the stable stage of chronic obstructive pulmonary disease. Eur J Clin Microbiol Infect Dis 2010;29:1487-93. doi: 10.1007/ s10096-010-1027-7.
  • 76. Wedzicha JA. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004;1:115-20.
  • 77. Tan WC, Xiang X, Qiu D, Ng TP, Lam SF, Hegele RG. Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. Am J Med 2003;115:272-7.
  • 78. Cameron RJ, de Wit D, Welsh TN, et al. Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation. Intensive Care Med 2006;32:1022-9.
  • 79. Seemungal T, Harper Owen R, Bhowmik A, Moric I, Sanderson G, Message S, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164:1618-23.
  • 80. Molyneaux PL, Mallia P, Cox MJ, Footitt J, Willis-Owen SA, Homola D, et al. Overgrowth of the bacterial microbiome after Rhinovirus exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013;188:1224-31. doi: 10.1164/rccm.201302-0341OC.
  • 81. Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev 2001;14:336-63.
  • 82. Chan ED, Iseman MD. Underlying host risk factors for nontuberculous mycobacterial lung disease. Semin Respir Crit Care Med 2013;34:110-23.
  • 83. Huerta A, Soler N, Esperatti M, Guerrero M, Menendez R, Gimeno A, et al. Importance of Aspergillus spp. isolation in acute exaerbations of severe COPD: prevelence, factors and follow-up: the FUNGI-COPD study. Respir Res 2014;15:17. doi: 10.1186/1465-9921-15-17.
  • 84. Donaldson GC, Goldring JJ, Wedzicha JA. Influence of season on exacerbation characteristics in patients with COPD. Chest 2012;141:94-100. doi: 10.1378/chest.11- 0281
  • 85. Jenkins CR, Celli B, Anderson JA, Ferguson GT, Jones PW, Vestboe J, et al. Seasonality and determinants of moderate and severe COPD exacerbations in the TORCH study. Eur Respir J 2012;9:38-40 doi: 10.1183/09031936.00194610.
  • 86. Patel AR, Hurst JR. Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art. Expert Rev Respir Med 2011;5:647-62. doi: 10.1586/ ers.11.62.
  • 87. Zvezdin B, Milutinov S, Kojicic M, Hadnadjev M, Hromis S, Markovic M, et al. A postmortem analysis of major causes of early death in patients hospitalized with COPD exacerbation. Chest 2009;136:376-80. doi: 10.1378/ chest.08-2918.
  • 88. McAllister DA, Maclay JD, Mills NL, Leitch A, Reid P, Carruthers R, et al. Diagnosis of myocardial infarction following hospiatlisation for exacerbation of COPD. Eur Respir J 2012;39:1097-103. doi: 10.1183/09031936. 00124811.
  • 89. Matamis D, Tsagourias M, Papathanasiou A, Sineffaki H3, Lepida D4, Galiatsou E, et al. Targeting occult heart failure in intensive care unit patient with acute chronic obstructive pulmonary disease exacerbation: Effect on outcome and quality of life. J Crit Care 2014;29:315. e7-14. doi: 10.1016/j.jcrc.2013.11.011.
  • 90. Freixa X, Portillo K, Paré C, Garcia-Aymerich J, Gomez FP, Benet M, et al. Echocardiographic abnormalities in patients with COPD at their first hospital admission. Eur Respir J 2013;41:784-91. doi: 10.1183/09031936.00222511.
  • 91. Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003;124:474-81.
  • 92. Erelel M, Cuhadaroglu C, Ece T, Arseven O. The frequency of deep vein thrombosis and pulmonary embolism in acute exacerbations of chronic obstructive pulmonary disease. Respir Med 2002;96:515-8.
  • 93. Schönhofer B, Köhler D. Prevalence of deep vein thrombosis of the leg in patients with acute exacerbations of chronic obstructive pulmonary disease. Respiration1998;65:173-7.
  • 94. Gunen H, Gulbas G, In E, Yetkin O, Hacievliyagil SS. Venous thromboemboli and exacerbations of COPD. Eur Respir J 2010;35:1243-8. doi: 10.1183/09031936.00120909.
  • 95. Rizkallah J, Man SF, Sin DD. Prevalence of pulmonary embolismin acute exacerbations of COPD. A systematic review and meta-analysis. Chest 2009;135:786-93. doi: 10.1378/chest.08-1516.
  • 96. Takada K, Matsumoto S, Kojima E, Iwata S, Okachi S, Ninomiya K, et al. Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire. Respir Med 2011;105:1531-6. doi: 10.1016/j.rmed.2011.03.009.
  • 97. Liang B, Wang M, Yi Q, Feng Y. Association of gastroesophageal reflux disease risk with exacerbations of chronic obstructive pulmonary disease. Dis Esophagus 2013;26:557-60. doi: 10.1111/dote.12014.
  • 98. Kim J, Lee JH, Kim Y, Kim K, Oh YM, Yoo KH, et al. Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: anationalcross-sectional cohort study. BMC Pul Med 2013;13:51. doi: 10.1186/1471-2466-13-51.
  • 99. Laurin C, Moullec G, Bacon SL, Lavoie KL. Impact of anxiety and aepression on chronic obstructive pulmonary disease exacerbation risk. Am J Respir Crit Care Med 2012:185;918-23. doi: 10.1164/rccm.201105-0939PP.
  • 100. Eisner MD, Blanc PD, Yelin EH, Katz PP, Sanchez G, Iribarren C, et al. Influence of anxiety on health outcomes in COPD. Thorax 2010;65:229-34. doi: 10.1136/ thx.2009.126201.
  • 101. Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, et al. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 2012;367:913-21. doi: 10.1056/NEJMoa1203830.
  • 102. Kucukcoskun M, Baser U, Öztekin G, Kiyan E, Yalcin F. Initial periodontal treatment for prevention of chronic obstructive pulmonary disease exacerbations. J Periodontol 2013;84:863-70. doi: 10.1902/jop.2012.120399.
  • 103. Kew KM, Seniukovich A. Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2014;3:CD010115. doi: 10.1002/14651858.CD010115.pub2.
  • 104. Jackson DJ, Sykes A, Mallia P, Johnston SL. Asthma exacerbations: origin, effect, and prevention. J Allergy and Clin Immunol 2011;128:1165-74. doi:10.1016/j. jaci.2011.10.024.
  • 105. Bateman ED, Buhl R, O'Byrne PM, Humbert M, Reddel HK, Sears MR, et al. Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations. J Allergy Clin Immunol 2014;pii:S0091- 6749:01187-7. doi: 10.1016/j.jaci.2014.08.015.
  • 106. Pride NB, Milic-Emili J. Lung mechanics. In: Calverley PMA, MacNee W, Pride NB, Rennard SI (eds). Chronic Obstructive Pulmonary Disease. London: Arnold, 2000:151-174.
  • 107. Roca M, Verduri A, Corbetta L, Clini E, Fabbri LM, Beghé B. Mechanisms of acute exacerbation of respiratory symptoms in chronic obstructive pulmonary disease. Eur J Clin Invest 2013;43:510-21,
  • 108. Parshall MB, Schwartzein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, et al. An official American Thoracic Society statement: update of mechanisms, assessment and managementof dyspnea. Am J Respir Crit Care Med 2012;185;435-52. doi: 10.1164/rccm.201111- 2042ST.
  • 109. Chung KF, Adcock IM How variability in clinical phenotypes should guide research into disease mechanisms in asthma. Ann Am Thorac Soc 2013;(Suppl 10):S109-S17.
  • 110. Au DH, Bryson CL, Chien JW, Sun H, Udris EM, Evans LE, et al. The effects of smoking cessation on the risk of COPD exacerbations. J Gen Intern Med 2009;24:457-63. doi: 10.1007/s11606-009-0907-y.
  • 111. Nichol KL, Baken L, Nelson A. Relation between influenza vaccination and out patient visits, hospitalization and mortality in elderly patients with chronik lung disease. Ann Intern Med 1999;130:397-403.
  • 112. Wedzicha JA, Seemungal TA. COPD exacerbations: definiting their cause and prevention. Lancet 2007;370:786-96.
  • 113. Alfageme I, Vazquez R, Reyes N, Muñoz J, Fernández A, Hernandez M, et al. Clinical efficacy of anti-pneumococcal vaccination in patients with COPD. Thorax 2006;61:189- 95.
  • 114. Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, et al. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation. Lancet 2000;355:362-8.
  • 115. Garcia-Aymerich J, Farrero E, Félez MA, Izquierdo J, Marrades RM, Antó JM; Estudi del Factors de Risc d'Agudització de la MPOC investigators. Risk faktors of readmission to hospital for COPD exacerbation: prospective study. Thorax 2003;58:100-5.
  • 116. Casanova C, Celli BR, Tost L, Soriano E, Abreu J, Velasco V, et al. Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD. Chest 2000;118:1582-90.
  • 117. Zahid I, Sharif S, Routledge T, Scarci M. Is volume reduction surgery effective in the treatment of advanced emphysema? Intract Cardiovasc Thorac Surg 2011;12:480-6. doi: 10.1510/icvts.2010.252213
  • 118. Washko GR, Fan VS, Ramsey SD, Mohsenifar Z, Martinez F, Make BJ, et al. The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med 2008;177:164-9.
  • 119. Dusser D, Bravo ML, Iacano P. The effect of tiotropium on exacerbations and airflow in patients with COPD. Eur Respir J 2006;27:547-55.
  • 120. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008;359:1543-54 doi: 10.1056/NEJMoa0805800.
  • 121. Anzueto A, Niewoehner DE, Leimer I, Rühmkorf F, Celli BR, Decramer M, et al. A post hoc pooled analysis of exacerbations among US participants in randomised controled trials of tiotropium. Respir Med 2013;107:1912- 22. doi: 10.1016/j.rmed.2013.07.020.
  • 122. Wang J, Nie B, Xiong W, Xu Y. Effect of long-acting betaagonists on the frequency of COPD exacerbations; metaanalysis. J Clin Pharmacy Ther 2012;37:204-11. doi: 10.1111/j.1365-2710.2011.01285.x.
  • 123. Aaron S, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, et al. Tiotropium in combination with plasebo, salmeterol, or fluticasone-salmeterol for treatment of COPD. Ann Intern Med 2007;146:545-55.
  • 124. Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007;356:775-7.
  • 125. Dransfiet MT, Bourbeau J, Jones PW, Hanania NA, Mahler DA, Vestbo J, et al. Once-daily inhaled fluticasone furuate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blinde, paralel-group, randomised controled trials. Lancet Respir Med 2013;1:210- 23. doi: 10.1016/S2213-2600(13)70040-7.
  • 126. Wedzicha JA, Calverley PMA, Seemurgal TA, Hagan G, Ansari Z, Stockley RA; INSPIRE Investigators. The prevention of COPD exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med 2008;177:19-26.
  • 127. Wedzicha JA, Rabe KF, Martinez FJ, Bredenbröker D, Brose M, Goehring UM, et al. Efficacy of roflumilast in the COPD frequent exacerbator phenotype. Chest 2013;143:1302- 11. doi: 10.1378/chest.12-1489.
  • 128. Calverley PMA, Rabe HF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ, et al. Roflumilast in semptomatik chronic obstructive pulmonary disease; two randomised clinical trial. Lancet 2009;374:685-94. doi: 10.1016/ S0140-6736(09)61255-1.
  • 129. Rennard SI, Calverley PM, Goehring UM, Bredenbröker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitors roflumilast--the importance of definiting differend susets of patients with COPD. Respir Res 2011;12:18. doi: 10.1186/1465-9921-12-18.
  • 130. Bateman ED, Rabe KF, Calverley PM, Goehring UM, Brose M, Bredenbröker D, et al. Roflumilast with long-acting beta2- agonist for COPD: influence of exacerbation history. Eur Respir J 2011;38:553-60. doi: 10.1183/09031936.00178710.
  • 131. Poole PJ, Black PN. Mucolytic agents for COPD. Cochrane Database Syst Rev 2006;3:CD001287.
  • 132. Miravitlles M, Soler-Cataluna JJ, Calle M, Molina J, Almagro P, Quintano JA, et al. Spanish COPD guidelines (GesEPOC): Pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. Arch Bronconeumol 2012;48:247-57.
  • 133. Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA Jr, Criner GJ, et al. Azitromycin for prevention of exacerbations of COPD. N Engl J Med 2011;365:689-98. doi: 10.1056/ NEJMoa1104623.
  • 134. Donalth E, Chaudhry A, Hernandez-Aya LF, Lit L. A metaanalysis on the prophylactic use of macrolide antibiotics fort he prevention of disease exacerbations in patients with Chronic Obstructive Pulmonary Disease. Respir Med 2013;107:1385-92. doi: 10.1016/j.rmed.2013.05.004.
  • 135. United State Food and Drug Administration. FDA Drug safety communication: Azitromycin (Zithromax or Zmax) and risk of potantially fatal heart rhythms. March 2013.
  • 136. Sethi S, Jones PW, Theron MS, Miravitlles M, Rubinstein E, Wedzicha JA, et al. Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Respir Res 2010;11:10. doi: 10.1186/1465-9921-11-10.
  • 137. Lasserson TJ, Ferrara G, Casali L. Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children. Cochrane Database Syst Rev 2011;12:CD004106. doi: 10.1002/14651858.CD004106.pub4 138. Cates CJ, Wieland LS, Oleszczuk M, Kew KM. Safety of regular formoterol or salmeterol in adults with asthma: an overview of Cochrane reviews. Cochrane Database Syst Rev 2014;2:CD010314. doi: 10.1002/14651858. CD010314.pub2.
  • 139. Kew KM, Karner C, Mindus SM, Ferrara G. Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev. 2013;12:CD009019. doi: 10.1002/14651858. CD009019.pub2.
  • 140. Chauhan BF, Ducharme FM. Addition to inhaled corticosteroids of long-acting beta2-agonists versus antileukotrienes for chronic asthma. Cochrane Database Syst Rev. 2014;1:CD003137. doi: 10.1002/14651858. CD003137.pub5.
  • 141. Hagan JB, Samant SA, Volcheck GW, Li JT, Hagan CR, Erwin PJ, et al. The risk of asthma exacerbation after reducing inhaled corticosteroids: a systematic review and metaanalysis of randomized controlled trials. Allergy 2014;69:510-6. doi: 10.1111/all.12368.
  • 142. Normansell R, Walker S, Milan SJ, Walters EH, Nair P. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev 2014;1:CD003559. doi: 10.1002/14651858.CD003559.pub4.
  • 143. Rebuck AS, Chapman KR, Abboud R, Pare PD, Kreisman H, Wolkove N, et al. Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. Am J Med 1987;82:59-64.
  • 144. Johnson MK, Stevenson RD. Management of an acute exacerbation of COPD: are we ignoring the evidence ? Thorax 2002;57(Suppl 2):SII15-SII23.
  • 145. Rennard SI. Treatment of stable chronic obstructive pulmonary disease. Lancet 2004;364:791-802
  • 146. Polverino E, Gomez FP, Manrique H, Soler N, Roca J, Barberà JA, et al. Gas exchange response to short acting beta2-agonists in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 2007;176: 350-5.
  • 147. McCrory DC, Brown CD. Anti-cholinergic bronchodilators versus beta2-sympathomimetic agents for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2002;CD003900.
  • 148. Moayyedi P, Congleton J, Page RL, Pearson SB, Muesr MF. Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. Thorax 1995;50:834-7.
  • 149. Nair S, Thomas E, Pearson SB. Henry MT. A randomized controlled trial to assess the optimal dose and effect of nebulized albuterol in acute exacerbations of COPD. Chest 2005;128:48-54. 150. Celli BR, MacNee W; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004;23:932-46
  • 151. Di Marco F, Verga M, Santus P, Morelli N, Cazzola M, Centanni S. Effect of formoterol, tiotropium and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease: a pilot study. Respir Med 2006;100:1925-32.
  • 152. Barr RG, Rowe BH, Camargo CA. Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomized trials. BMJ 2003;327:643.
  • 153. Quon BS, Gan WQ, Sin DD. Contemporary management of acute exacerbations of COPD: a systematic review and meta-analysis. Chest 2008;133:756-66. doi: 10.1378/ chest.07-1207.
  • 154. Llor C, Moragas A, Hernandez S, et al. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;186:716-23. doi: 10.1164/rccm.201206-0996OC.
  • 155. Vollenweider DJ, Jarrett H, Steurer-Stey CA, GarciaAymerich J, Puhan MA. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012;12:CD010257. doi: 10.1002/14651858. CD010257.
  • 156. Başoğlu ÖK, Sayıner AA, Zeytinoğlu A, Sayıner A. The role of atypical bacteria in acute exacerbations of chronic obstructive pulmonary disease. Turkish Respiratory Journal 2005;6:22-27.
  • 157. Siempos II, Dimopoulos G, Korbila IP, Manta K, Falagas ME. Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-aanlysis. Eur Respir J 2007;29: 1127-37.
  • 158. Schembri S, Williamson PA, Short PM, Singanayagam A, Akram A, Taylor J, et al. Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies. BMJ 2013;346:f1235. doi: 10.1136/bmj.f1235.
  • 159. Walters JA, Gibson PG, Wood-Baker R, Hannay M, Walters EH. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2009;CD001288. doi: 10.1002/14651858. CD001288.pub3.
  • 160. Sayıner A, Aytemur ZA, Cirit M, Ünsal I. Systemic glucocorticoids in severe exacerbations of COPD. Chest 2001;119:726-30.
  • 161. Leuppi JD, Schuetz P, Bingisser R, Bodmer M, Briel M, Drescher T, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA 2013;309:2223-31. doi: 10.1001/jama.2013.5023.
  • 162. Lindenauer PK, Pekow PS, Lahti MC, Lee Y, Benjamin EM, Rothberg MB. Association of corticosteroid use and route of administration with risk of treatment failure in avute exacerbations of chronic obstructive pulmonary disease. JAMA 2010;303:2359-67. doi: 10.1001/jama.2010.796.
  • 163. Çeviker Y, Sayıner A. Comparison of two systemic steroid regimens for the treatment of COPD exacerbations. Pulm Pharmacol Ther 2014;27:179-83. doi: 10.1016/j. pupt.2013.03.004.
  • 164. Maltais F, Ostinelli J, Bourbeau J, Tonnel AB, Jacquemet N, Haddon J, et al. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Am J Respir Crit Care Med 2002;165:698-703.
  • 165. Günen H, Hacıevliyagil SS, Yetkin O, Gülbaş G, Mutlu LC. The role of nebulised budesonide in the treatment of exacerbations of COPD. Eur Respir J 2007;29:660-7.
  • 166. Black PN, Morgan-Day A, McMillan TE, Poole PJ, Young RP. Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med 2004;4:13.
  • 167. Aytemur ZA, Baysak A, Özdemir Ö, Sayiner A. N-Acetylcysteine in exacerbations of chronic obstrutive pulmonary disease associated with increased sputum. Am J Respir Crit Care Med 2011;183:A3123.
  • 168. Isbaniah F, Wiyono WH, Yunus F, Setiawati A, Totzke U, Verbruggen MA. Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial. J Clin Pharm Ther 2011;36:568- 57. doi: 10.1111/j.1365-2710.2010.01212.x.
  • 169. Stefan MS, Rothberg MB, Priya A, Pekow PS, Au DH, Lindenauer PK. Association between beta-blocker therapy and outcomes in patients hospitalized with acute exacerbations of chronic obstructive lung diasease with underlying ischemic heart disease, heart failure or hypertension. Thorax 2012;67:977-984. doi: 10.1136/ thoraxjnl-2012-201945.
APA YILDIRIM N, DEMİR T, Gemicioglu B, KIYAN E, OĞUZÜLGEN İ, POLATLI M, SARYAL S, Sayiner A, yorgancıoglu a, Bavbek S, ÇELİK G, Gunen H, MUNGAN V, SEN E, TÜRKTAŞ H, Yildiz F (2015). KOAH ve astımda atak. , 111 - 131.
Chicago YILDIRIM Nurhayat,DEMİR Tunçalp,Gemicioglu Bilun,KIYAN Esen,OĞUZÜLGEN İPEK KIVILCIM,POLATLI MEHMET,SARYAL SEVGI BEHIYE,Sayiner Abdullah,yorgancıoglu arzu,Bavbek Sevim,ÇELİK Gülfem E.,Gunen Hakan,MUNGAN VESİLE DİLŞAD,SEN ELIF,TÜRKTAŞ HALUK ŞABAN,Yildiz Fusun KOAH ve astımda atak. (2015): 111 - 131.
MLA YILDIRIM Nurhayat,DEMİR Tunçalp,Gemicioglu Bilun,KIYAN Esen,OĞUZÜLGEN İPEK KIVILCIM,POLATLI MEHMET,SARYAL SEVGI BEHIYE,Sayiner Abdullah,yorgancıoglu arzu,Bavbek Sevim,ÇELİK Gülfem E.,Gunen Hakan,MUNGAN VESİLE DİLŞAD,SEN ELIF,TÜRKTAŞ HALUK ŞABAN,Yildiz Fusun KOAH ve astımda atak. , 2015, ss.111 - 131.
AMA YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F KOAH ve astımda atak. . 2015; 111 - 131.
Vancouver YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F KOAH ve astımda atak. . 2015; 111 - 131.
IEEE YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F "KOAH ve astımda atak." , ss.111 - 131, 2015.
ISNAD YILDIRIM, Nurhayat vd. "KOAH ve astımda atak". (2015), 111-131.
APA YILDIRIM N, DEMİR T, Gemicioglu B, KIYAN E, OĞUZÜLGEN İ, POLATLI M, SARYAL S, Sayiner A, yorgancıoglu a, Bavbek S, ÇELİK G, Gunen H, MUNGAN V, SEN E, TÜRKTAŞ H, Yildiz F (2015). KOAH ve astımda atak. Tüberküloz ve Toraks, 63(2), 111 - 131.
Chicago YILDIRIM Nurhayat,DEMİR Tunçalp,Gemicioglu Bilun,KIYAN Esen,OĞUZÜLGEN İPEK KIVILCIM,POLATLI MEHMET,SARYAL SEVGI BEHIYE,Sayiner Abdullah,yorgancıoglu arzu,Bavbek Sevim,ÇELİK Gülfem E.,Gunen Hakan,MUNGAN VESİLE DİLŞAD,SEN ELIF,TÜRKTAŞ HALUK ŞABAN,Yildiz Fusun KOAH ve astımda atak. Tüberküloz ve Toraks 63, no.2 (2015): 111 - 131.
MLA YILDIRIM Nurhayat,DEMİR Tunçalp,Gemicioglu Bilun,KIYAN Esen,OĞUZÜLGEN İPEK KIVILCIM,POLATLI MEHMET,SARYAL SEVGI BEHIYE,Sayiner Abdullah,yorgancıoglu arzu,Bavbek Sevim,ÇELİK Gülfem E.,Gunen Hakan,MUNGAN VESİLE DİLŞAD,SEN ELIF,TÜRKTAŞ HALUK ŞABAN,Yildiz Fusun KOAH ve astımda atak. Tüberküloz ve Toraks, vol.63, no.2, 2015, ss.111 - 131.
AMA YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F KOAH ve astımda atak. Tüberküloz ve Toraks. 2015; 63(2): 111 - 131.
Vancouver YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F KOAH ve astımda atak. Tüberküloz ve Toraks. 2015; 63(2): 111 - 131.
IEEE YILDIRIM N,DEMİR T,Gemicioglu B,KIYAN E,OĞUZÜLGEN İ,POLATLI M,SARYAL S,Sayiner A,yorgancıoglu a,Bavbek S,ÇELİK G,Gunen H,MUNGAN V,SEN E,TÜRKTAŞ H,Yildiz F "KOAH ve astımda atak." Tüberküloz ve Toraks, 63, ss.111 - 131, 2015.
ISNAD YILDIRIM, Nurhayat vd. "KOAH ve astımda atak". Tüberküloz ve Toraks 63/2 (2015), 111-131.