The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy

YILMAZ, MEHMET; PEHLİVAN, MUSTAFA; ÖZKÜR, Ayhan; ZENGİN, Orhan; OKAN, Vahap; SAYINER, Zeynel A.; SAHIN, Handan H.

The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy

Orhan ZENGİN, (Gaziantep Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep, Türkiye)

Vahap OKAN, (Gaziantep Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye)

Ayhan ÖZKÜR, (Gaziantep Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Gaziantep, Türkiye)

Zeynel A. SAYINER, (Gaziantep Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep, Türkiye)

Handan H. SAHIN, (Gaziantep Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye)

Mehmet YILMAZ, (Gaziantep Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye)

Mustafa PEHLİVAN (Gaziantep Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Gaziantep, Türkiye)

Uluslararası Hematoloji-Onkoloji Dergisi

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Yıl: 2015 Cilt: 25 Sayı: 1 Sayfa Aralığı: 32 - 37 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy

Öz:

Hemofilinin en sık komplikasyonu hemofilik artropatidir. Bu nedenle hemofili takip ve tedavisindeki en önemli unsurdur. Bu çalışmada hemofilik artropati kanama, radyolojik değerlendirme ve fizik muayene yönünden değerlendirildi. Ayrıca hemofilik artropatinin sosyoekonomik sonuçları ve yaşam kalitesi üzerine etkileri araştırıldı. Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalında hemofili tanısıyla takip edilen 40 erkek hasta dahil edildi. Hastalardan 34ü hemofili A, 6sı hemofili B idi. Faktör düzeylerine göre ise 20 hasta (%50) ağır hemofili, 8 hasta (%20) orta hemofili, 12 hasta (%30) hafif hemofili idi. Çalışmamızda elde edilen sonuçlara göre hemofilik artropati oluşumunun faktör düzeyiyle yakından ilişkili olduğu görülmüştür.Faktör düzeyi ile kanama sayısı (p< 0.05), eklemin fonksiyonel değerlendirme (p< 0.05) ve radyolojik değerlendirme skorları (p<0.05) arasında negatif korelasyon olduğu görülmüştür. Hastaların bir yıllık dönemdeki eklem kanama sayısı eklemin fonksiyonel değerlendirmesi (p< 0.01) ve radyolojik değerlendirme (p< 0.01) arasında anlamlı pozitif ilişki olduğu görüldü. Kanama sayısının arttığı, fizik muayene ve radyolojik değerlendirme skorları yüksek olan ilerlemiş artropatisi olan hastaların yaşam kalitelerinde azalma görülmüştür. Ayrıca kanama sayısı artması ile faktör tüketimi ve tedavi masrafları artmaktadır. Hemofilik artropati kişiye ve topluma gerek sosyal gerek ekonomik açıdan önemli oranda yük bindiren ciddi bir sağlık sorunudur. Tam anlamıyla tedavisi erken yaşlarda başlamak üzere eklem kanamalarının önlenmesi, var olan sakatlıkların düzeltilmesi ve hastaların topluma kazandırılmaları ile mümkün olabilir.

Anahtar Kelime:

Konular: Onkoloji

Hemofilik Hastalarda Hemofilik Artropatinin Kanama Sıklığı ve Şiddeti İle İlişkisi, Artropatinin Radyolojik Değerlendirmesi ve Sosyoekonomik Sonuçları

Öz:

Hemophilic arthropathy is the most common complication of hemophilia, and the most important element for follow-up and treatment of hemophilia. In this study, hemophilic arthropathy was evaluated for bleeding, radiological assessment, and physical examination. Besides, socio-economic outcomes of hemophilic arthropathy and its impacts on quality of life were also investigated. Forty male patients diagnosed with hemophilia in the Hematology Unit of Gaziantep University Medical Faculty were included in the study. Of the 40 patients, 34 had hemophilia A and 6 had hemophilia B; 20 (50%) had severe, 8 (20%) had moderate and 12(30%) had mild hemophilia. According to our data collected in this study, there was a close relationship between hemophilic arthropathy and factor level. It was detected that the factor level and frequency of bleeding (p< 0.05), functional assessment of joints (p< 0.05) and scores of radiological assessment (p< 0.05) was negatively correlated. Frequency of joint bleeding during one-year period had a significantly positive correlation with functional assessment of joints (p< 0.01) and scores of radiological assessment (p< 0.01). It was observed that quality of life impaired in advanced arthropathy patients whose physical examination and radiological assessment scores were high among those who had more frequent bleedings. In addition, with increased frequency of bleeding, factor consumption and treatment costs are also increasing. Hemophilic arthropathy is a serious disease that imposes a large economic burden on patients and society. The full treatment of the disease may only be possible if the treatment is started at an early age and during this period it is crucially important to prevent joint bleedings, rehabilitate disabilities, and to introduce patients into society.

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ZENGİN O, OKAN V, ÖZKÜR A, SAYINER Z, SAHIN H, YILMAZ M, PEHLİVAN M (2015). The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. , 32 - 37.
Chicago	ZENGİN Orhan,OKAN Vahap,ÖZKÜR Ayhan,SAYINER Zeynel A.,SAHIN Handan H.,YILMAZ MEHMET,PEHLİVAN MUSTAFA The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. (2015): 32 - 37.
MLA	ZENGİN Orhan,OKAN Vahap,ÖZKÜR Ayhan,SAYINER Zeynel A.,SAHIN Handan H.,YILMAZ MEHMET,PEHLİVAN MUSTAFA The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. , 2015, ss.32 - 37.
AMA	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. . 2015; 32 - 37.
Vancouver	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. . 2015; 32 - 37.
IEEE	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M "The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy." , ss.32 - 37, 2015.
ISNAD	ZENGİN, Orhan vd. "The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy". (2015), 32-37.

APA	ZENGİN O, OKAN V, ÖZKÜR A, SAYINER Z, SAHIN H, YILMAZ M, PEHLİVAN M (2015). The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. Uluslararası Hematoloji-Onkoloji Dergisi, 25(1), 32 - 37.
Chicago	ZENGİN Orhan,OKAN Vahap,ÖZKÜR Ayhan,SAYINER Zeynel A.,SAHIN Handan H.,YILMAZ MEHMET,PEHLİVAN MUSTAFA The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. Uluslararası Hematoloji-Onkoloji Dergisi 25, no.1 (2015): 32 - 37.
MLA	ZENGİN Orhan,OKAN Vahap,ÖZKÜR Ayhan,SAYINER Zeynel A.,SAHIN Handan H.,YILMAZ MEHMET,PEHLİVAN MUSTAFA The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. Uluslararası Hematoloji-Onkoloji Dergisi, vol.25, no.1, 2015, ss.32 - 37.
AMA	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. Uluslararası Hematoloji-Onkoloji Dergisi. 2015; 25(1): 32 - 37.
Vancouver	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy. Uluslararası Hematoloji-Onkoloji Dergisi. 2015; 25(1): 32 - 37.
IEEE	ZENGİN O,OKAN V,ÖZKÜR A,SAYINER Z,SAHIN H,YILMAZ M,PEHLİVAN M "The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy." Uluslararası Hematoloji-Onkoloji Dergisi, 25, ss.32 - 37, 2015.
ISNAD	ZENGİN, Orhan vd. "The Relationship of Frequency and Intensity of Bleeding with Hemophilic Arthropathy in Hemophilia Patients, Radiological Assesment and Socio-Economic Impacts of the Arthropathy". Uluslararası Hematoloji-Onkoloji Dergisi 25/1 (2015), 32-37.