ARZU COMBA
(Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Van, Türkiye)
HANDAN MERT
(Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Van, Türkiye)
BAHAT COMBA
(Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Van, Türkiye)
Yıl: 2014Cilt: 25Sayı: 3ISSN: 1017-8422 / 1308-3651Sayfa Aralığı: 87 - 91Türkçe

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Leptin ve Metabolik Etkileri
Leptin, son zamanlarda keşfedilen ve önemi giderek artan metabolik bir hormondur. Leptinin esas salınım yeri ve etkisi yağ dokusu olarak bilinse de, yapılan son çalışmalar leptinin ve leptin reseptörlerinin vücudun diğer organlarında da üretildiğini kanıtlamaktadır. Leptin metabolik etkilerinin çoğunu merkezi sinir sisteminde ve periferik dokularda bulunan reseptörlerle etkileşerek göstermektedir. Bu derlemede, leptinin yapısı, salgılanması, karbonhidrat ve lipit metabolizmasına, kilo artışına etkisi değerlendirilmiştir.
Fen > Veterinerlik > Veterinerlik
DergiAraştırma MakalesiErişime Açık
  • Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. (1996). Role of leptin in the neuroendocrine response to fasting. Nature, 382, 250-252. Auwerx J, Staels B (1998). Leptin. The Lancet, 351, 737-742. Bado A, Levasseur S, Le Marchand-Brustel Y, Lewin MJM (1998). The stomach is a source of Leptin, Nature, 394, 790-793. Baile CA, Della-Fera MA, Martin RJ (2000). Regulation of metabolism and body fat mass by leptin. Ann Rev Nutrition, 20, 105-127. Banks WA (2001). Leptin transport across the blood brain barrier: Implication for the cause and treatment of obesity. Curr Pharm Des, 7, 125-133. Barb CR, Hausmane GJ, Houseknecht KL (2001). Biology of leptin in the pig. Domestic Anim Endocrinol, 21, 297-317. Bartness TJ, Bamshad M (1998). Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol, 275, 1399-1411. Bennet BD, Solar GP, Yuan JO, Thomas GR (1996). A role for leptin and its cognate receptor in haematopoiesis. Curr Biol, 6, 1170-1180. Boden G, Chen X, Mozzoli M, Ryan I (1996). Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab, 81, 3419-23. Brabant G, Horn R, Mary M, Wuster U, Schnabel D, Heindenreich F (2000). Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia, 43, 438-42. Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A (2001). Leptin in reproduction. Trends in Endocrinol & Metabol, 12, 65-72. Cha MC, Jones PJ (1998). Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. J Lipit Res, 39, 1655-1660. Chehab FF, Lim ME, Lu R (1996). Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant Leptin. Nat Genet, 12, 318-320. Chelikani PK, Ambrose JD, Keisler DH, Kennelly JJ (2004). Effect of short term fasting on plasma concentrations of leptin and other hormones and metabolites in dairy cattle. Dom Anim Endocrinol, 26, 33-48. Chilliard Y, Bonnet M, Delavaud C, Faulconniera Y, Lerouxb C, Djianec J, Bocquierd F (2001). Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Dom Anim Endocrinol, 21, 271–295. Chilliard Y, Ferlay A, Faulconnier Y, Bonnet M, Rouel J, Bocquier F (2000). Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants. Proc Nutr Society, 59: 127-134. Christos S, Mantzoros MD (1999). The role of leptin in human obesity and disease: A review of current evidience. Ann Intern Med, 13, 671-680. Clement K (1999). Leptin and the genetics of obesity. Acta Pediatr, Suppl 428:51-57. Comba A (2014). Farklı koyun ırklarında leptin ve lipit profili düzeylerinin belirlenmesi. Y. Y. Ü. Sağlık Bilimleri Enstitüsü Biyokimya Anabilim Dalı Doktora Tezi, Van. D’Adamo M, Buongiorno A, Maroccia E, Leonetti F, Barbetti F, Giaccari A, Zorretta D, Tamburrano G, Sbraccia P (1998). Increased OB gene expression leads to elevated plasma leptin concentrations in patients with chronic primary hyperinsulinemia. Diabetes, 47, 10, 625-9. Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y (2002). Plasma leptin concentration in adult cattle: effects of breed, adiposity, feeding level, and meal intake. J Anim Sci, 80, 1317-1328. Dulloo AG, Stock MJ, Solinas G, Boss O, Montani JP, Seydoux J (2002). Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Letters, 515, 109-113. Friedman JM, Halaas JL (1998). Leptin and the regulation of body weight in mammals. Nature, 395, 763-70. Fruhbeck G, Jebb SA, Prentice AM (1998). Leptin: physiology and pathophysiology. Clin Physiol, 18, 399-419. Goumenou AG, Matalliotakis IM, Koumantakis GE, Panidis DK (2002). The role of leptin in fertility. Eur J Obs & Gyn Reprod Biol, 106, 118-124, Guerre-Millo M (2002). Adipose tissue hormones. J Endocrinol Invest, 25, 855-861. Harris RB (1998). Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem Biophys Res Commun, 245, 502-509. Harris RBS, Zhou J, Weigle DS, Kuijper JL (1997). Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium. Am J Physiol, 272, R1800– R1808. Hekimoğlu A (2006). Leptin ve fizyopatolojik olaylardaki rolü. Dicle Tıp Derg, 33, 4, 259-267. Himms-Hagen J (1999). Physiological roles of the leptin endocrine system: Differences between Mice and Humans. Crit Rev Cl Lab Sci, 36, 6, 575- 655. Houseknecht KL, Baıle CA, Matterı RI, Spurlocks ME (1998). The biology of leptin: a review. Journal of Animal Science, 76, 1405-1420. Houseknecht KL, Portocarrero CP (1998). Leptin and its receptors: regulators of whole-body energy homeostasis. Domest Anim Endocrin, 15, 457-475. Iwaniec UT, Heaney RP, Cullen DM, Yee JA (1998). Leptin increases the number of mineralized bone nodules in vitro. J Bone Miner Res, 13, 2- 12. Jeanrenaud B, Jeanrenaud R (2002). Nöropetidler ve leptinin besin alımı ve obezitedeki rolü. Editör: Dursun N, International Textbook of Obesity, 1 baskı, AND Danışmanlık & Yayıncılık, İstanbul, sayfa 101- 112. Jin L, Burguera BG, Couce ME, Scheıthauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV (1999). Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocr Metab, 84, 2903- 2911. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ (1997). Acute stimulation of glucose metabolism in mice by leptin treatment. Nature, 389, 74-377. Karlsson C (2000). Leptin-a slimmer’s dream that crashed? J Int F Clin Chem Lab Med, 12, 1-9. Kim KH (1996). Scientists Sprint to Understand Fat-Busting Protein Leptin. Purdue News, 11. Kirel B, Doğruel N (1998). Yeni bir hormon: Leptin. Sürekli Tıp Eğt Derg, 7, 421-423. Klaus S (2004). Adipose tissue as a regulatorof energy balance. Curr Drug Targets, 5, 241-50. Klein S, Coppack SW, Mohamed-Ali V, Landt M (1996). Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes, 45, 984–987. Maffei M, Stoffel M. Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig DS, Flier JS, Talley M (1996). Absence of mutations in the human OB gene in Obese/diabetic subjects. Diabetes, 45, 675-678. Meier U, Gressner AM (2004). Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin and resistin. Clin Chem, 50, 9, 1511-1525. Mizuno A, Murakami T, Otani S, Kuwajima M, Shima K (1998). Leptin affects pancreatic endocrine functions through the sympathetic nervous system. Endocrinology, 139, 3863-3870. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387, 903–908. Moran O, Phillip M (2003). Leptin: obesity, diabetes, and other peripheral effects- a review. Pediatr Diabetes, 4, 101-109. Morton NM, Emilsson V, De Groot P, Pallett AL, Cawthorne MA (1999). Leptin signalling in pancreatic islets and clonal insulin-secreting cells. Journal of Molecular Endocrinology, 22, 173-184. Muoio DM, Dohm GL, Fiedorek FT, Tapscott EB, Coleman RA, Dohn GL (1997). Leptin directly alters lipit partitioning in skeletal muscle. Diabetes, 46, 1360-1363. Muzumdar R, Ma X, Yang X, Atzmon G, Bernstein J, Karkanias G, Barzılai N (2003). Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J, 17, 1130-1132. Pelleymounter M, Cullen MJ, Baker MB, Hecht R, Winters D, Bone T, Collins F (1995). effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540-543. Pratley RE, Nicolson M, Bogardus C, Ravussin, E (1997). Plasma leptin responses to fasting in Pima Indians. Am J Physiol, 273, E644–E649. Prolo P, Wong ML, Licinio J (1998). Leptin. Int J Biochem Cell Biol, 30, 1285-1290. Scarpace PJ, Matheny M (1998). Leptin induction of UCP1 gene expression is dependent on sympathetic innervation. Am J Physiol, 275, 259-264. Schoeller DA, Cella LK, Sinha MK, Caro JF (1997). Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest, 100, 1882–1887. Schwartz MW, Seeley RJ (1997). Neuroendocrine responses to starvation and weight loss, New Eng J Med, 19, 1807-1811. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH (1997). Direct antidiabetic effect of leptin through triglyceride depletion of tissues. P Natl Acad Sci USA, 94, 4637-4641. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, Boss O, Pernin A, Chin WW, Cusin I, Rohner-Jeanrenaud F, Burger AG, Zapf J, Meier CA (1997). Direct effects of leptin on brown and white adipose tissue. J Clin Invest, 100, 2858-2864. Teker Z, Özer G, Topaloglu K, Mungan NÖ, Yüksel B (2002). Leptin yapı ve fizyolojisi. Arşiv, 11, 30-40. Thong FSL, Graham TE (1999). Leptin and reproduction: is it a critical link between adipose tissue, nutrition, and reproduction? Can J Appl Physiol, 24, 317-336. Van Aggel-Leijssen DPC, van Baak MA, Tenenbaum R, Campfield LA, Saris WHM (1999). Regulation of average 24h human plasma leptin level; the influence of exercise and physiological changes in energy balance. Int J Obesity, 23, 151–158. Vila R, Adan C, Rafecas I, Fernandez-Lopez JA, Remesar X, Alemany M (1998). Plasma leptin turnover rates in lean and obese Zucker rats. Endocrinology, 139: 4466–4469. Wang JL, Chinookoswong N, Scully S, Qi M, Shİ ZQ (1999b). Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology, 140, 2117-2124. Wang ZW, Zhou YT, Lee Y, Hıga M, Kalra SP, Unger RH (1999a). Hyperleptinemia depletes fat from denervated fat tissue. Biochem Bioph Res Co, 260, 653-657. Yıldız S, Blache D, Çelebi F, Kaya I, Saatçi M, Çenesiz M, Güven B (2003). Effects of short-term high carbohydrate or fat intakes on leptin, growth hormone and luteinizing hormone secretions in prepubertal fat-tailed tuj lambs. Reprod Dom Anim, 38, 182-186. Yu Wh, Kimura M, Walczewska A, Karanth S, Mccann SM (1997). Role of leptin in hypothalamic-pituitary function. P Natl Acad Sci USA, 94, 1023-1028. Zeng J, Patterson BW, Klein S, Martin DR, Dagogo-Jack S, Kohrt WM, Miller SB, Landt M (1997). Whole body leptin kinetics and renal metabolism in vivo. Am J Physiol, 273, 1102–1106. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432. Zierath JR, Frevert EU, Ryder JW, Berggren PO, Kahn BB (1998). Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes, 47, 1-4.

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