Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome
Yıl: 2015 Cilt: 30 Sayı: 4 Sayfa Aralığı: 334 - 342 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome
Öz: Objectives: This study aims to determine monocyte expression levels of interleukin 1 beta (IL-1β), IL-6, IL-8, and tumor necrosis factor alpha infibromyalgia syndrome (FMS) patients and healthy females. Patients and methods: A total of 80 female FMS patients and 50 healthy females were evaluated. Twelve of the FMS patients who did not meet the1990 American College of Rheumatology criteria and 10 healthy controls were excluded. After exclusion 68 participants as FMS patient (mean age41.41±7.14 years; range 18 to 55 years) and 40 participants as control group (mean age 39.12±10.9 years; range 18 to 55 years) were included in thestudy. For both groups, a detailed form was filled out which included information on age, body mass index, marital status, educational status, visualanalog scale, fibromyalgia impact questionnaire, Hamilton anxiety scale, Hamilton depression scale, modified fatigue impact scale, and Nottinghamhealth profile. Whole blood peripheral blood monocyte cells were drawn in ethylenediaminetetraacetic acid tubes from patient and control groupsbetween 08:30 to 9:30 hours. Tumor necrosis factor alpha, IL-6, IL-8, and IL-1β expressions were evaluated using fluorescence-activated cell sortingflow cytometry device. Results: No statistically significant difference was detected between the two groups in terms of average age, body mass index, and otherdemographic data (p>0.05). Visual analog scale, Hamilton anxiety scale, Hamilton Depression Scale, fibromyalgia impact questionnaire, modifiedfatigue impact scale total score and Nottingham health profile total-subscore values were statistically significantly higher in the patient group thanthe control group (p<0.001). No significant difference was found in expression of cytokines by monocytes in patients with FMS (p>0.05). Conclusion: Although FMS is not traditionally considered an inflammatory disorder, evidence for elevated inflammatory processes has been notedin some studies. Our results do not support any role of the inflammatory cytokines in the pathogenesis of FMS.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | ÖĞÜT E, Gur A, KOÇYİĞİT B, ÖZTUZCU S, CENGIZ B, ALTINDAĞ Ö, KARAGÜLLÜ H, Gursoy S (2015). Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. , 334 - 342. |
Chicago | ÖĞÜT Evrim,Gur Ali,KOÇYİĞİT Burhan Fatih,ÖZTUZCU Serdar,CENGIZ Beyhan,ALTINDAĞ Özlem,KARAGÜLLÜ Hilal,Gursoy Savas Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. (2015): 334 - 342. |
MLA | ÖĞÜT Evrim,Gur Ali,KOÇYİĞİT Burhan Fatih,ÖZTUZCU Serdar,CENGIZ Beyhan,ALTINDAĞ Özlem,KARAGÜLLÜ Hilal,Gursoy Savas Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. , 2015, ss.334 - 342. |
AMA | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. . 2015; 334 - 342. |
Vancouver | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. . 2015; 334 - 342. |
IEEE | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S "Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome." , ss.334 - 342, 2015. |
ISNAD | ÖĞÜT, Evrim vd. "Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome". (2015), 334-342. |
APA | ÖĞÜT E, Gur A, KOÇYİĞİT B, ÖZTUZCU S, CENGIZ B, ALTINDAĞ Ö, KARAGÜLLÜ H, Gursoy S (2015). Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. Archives of Rheumatology, 30(4), 334 - 342. |
Chicago | ÖĞÜT Evrim,Gur Ali,KOÇYİĞİT Burhan Fatih,ÖZTUZCU Serdar,CENGIZ Beyhan,ALTINDAĞ Özlem,KARAGÜLLÜ Hilal,Gursoy Savas Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. Archives of Rheumatology 30, no.4 (2015): 334 - 342. |
MLA | ÖĞÜT Evrim,Gur Ali,KOÇYİĞİT Burhan Fatih,ÖZTUZCU Serdar,CENGIZ Beyhan,ALTINDAĞ Özlem,KARAGÜLLÜ Hilal,Gursoy Savas Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. Archives of Rheumatology, vol.30, no.4, 2015, ss.334 - 342. |
AMA | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. Archives of Rheumatology. 2015; 30(4): 334 - 342. |
Vancouver | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome. Archives of Rheumatology. 2015; 30(4): 334 - 342. |
IEEE | ÖĞÜT E,Gur A,KOÇYİĞİT B,ÖZTUZCU S,CENGIZ B,ALTINDAĞ Ö,KARAGÜLLÜ H,Gursoy S "Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome." Archives of Rheumatology, 30, ss.334 - 342, 2015. |
ISNAD | ÖĞÜT, Evrim vd. "Monocyte Expression Levels of Cytokines in Patients With Fibromyalgia Syndrome". Archives of Rheumatology 30/4 (2015), 334-342. |