Yıl: 2015 Cilt: 15 Sayı: 2 Sayfa Aralığı: 132 - 136 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major

Öz:
Objective: Beta-thalassemia major (TM) is a genetic hemoglobin disorder causing chronic hemolytic anemia. Since cardiac insufficiency and arrhythmias are the primary causes of mortality in such patients, monitoring of cardiac iron load is important in management of the disorder. The purpose of this study was to investigate the importance of fragmented QRS (fQRS) and its relation to the cardiac T2* value for the evaluation of cardiac iron load in TM patients. Methods: This retrospective study included 103 TM patients. The patients T2* values, measured by cardiac MRI and 12-lead surface ECGs, were interpreted. The cardiac T2* values under 20 were considered as cardiac iron overload. The relationship between the cardiac T2* value and fQRS in ECG was investigated. Results: The median age of the patients was 22.6±6.6 years. All patients were on regular blood transfusions and iron chelators. The patients had no risk factors for coronary artery disease. In 50 (48%) patients fQRS was detected, and in 37 (74%) of these the T2* values were low. 86% of patients with cardiac involvement (37) had fQRS, but 22% of patients with non-involvement (13) had fQRS (p<0.001). Conclusion: Since cardiac involvement is the primary cause of mortality in TM patients, the early diagnosis of cardiac dysfunction is of vital importance. The search for fQRS in the ECGs of these patients, particularly when cardiac T2* values cannot be determined and followed, is a non-expensive and easy-to-attain method for therapy management. (Anatolian J Cardiol 2015; 15: 132-6)
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Bayar N, Kurtoglu E, ARSLAN S, Erkal Z, Cay S, ÇAĞIRCI G, DEVECİ B, KÜÇÜKSEYMEN S (2015). Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. , 132 - 136.
Chicago Bayar Nermin,Kurtoglu Erdal,ARSLAN SAKIR,Erkal Zehra,Cay Serkan,ÇAĞIRCI Göksel,DEVECİ BURAK,KÜÇÜKSEYMEN Selçuk Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. (2015): 132 - 136.
MLA Bayar Nermin,Kurtoglu Erdal,ARSLAN SAKIR,Erkal Zehra,Cay Serkan,ÇAĞIRCI Göksel,DEVECİ BURAK,KÜÇÜKSEYMEN Selçuk Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. , 2015, ss.132 - 136.
AMA Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. . 2015; 132 - 136.
Vancouver Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. . 2015; 132 - 136.
IEEE Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S "Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major." , ss.132 - 136, 2015.
ISNAD Bayar, Nermin vd. "Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major". (2015), 132-136.
APA Bayar N, Kurtoglu E, ARSLAN S, Erkal Z, Cay S, ÇAĞIRCI G, DEVECİ B, KÜÇÜKSEYMEN S (2015). Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. The Anatolian Journal of Cardiology, 15(2), 132 - 136.
Chicago Bayar Nermin,Kurtoglu Erdal,ARSLAN SAKIR,Erkal Zehra,Cay Serkan,ÇAĞIRCI Göksel,DEVECİ BURAK,KÜÇÜKSEYMEN Selçuk Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. The Anatolian Journal of Cardiology 15, no.2 (2015): 132 - 136.
MLA Bayar Nermin,Kurtoglu Erdal,ARSLAN SAKIR,Erkal Zehra,Cay Serkan,ÇAĞIRCI Göksel,DEVECİ BURAK,KÜÇÜKSEYMEN Selçuk Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. The Anatolian Journal of Cardiology, vol.15, no.2, 2015, ss.132 - 136.
AMA Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. The Anatolian Journal of Cardiology. 2015; 15(2): 132 - 136.
Vancouver Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major. The Anatolian Journal of Cardiology. 2015; 15(2): 132 - 136.
IEEE Bayar N,Kurtoglu E,ARSLAN S,Erkal Z,Cay S,ÇAĞIRCI G,DEVECİ B,KÜÇÜKSEYMEN S "Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major." The Anatolian Journal of Cardiology, 15, ss.132 - 136, 2015.
ISNAD Bayar, Nermin vd. "Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major". The Anatolian Journal of Cardiology 15/2 (2015), 132-136.