The relationship between Polycystic ovary syndrome and vitamin D levels

KEBABÇILAR, Ayşegül; PEKİN TAZEGÜL, Aybike; ALTINKAYA, Sündüz Özlem; ABUŞOĞLU, Sedat; YILMAZ, Setenay Arzu; celik, cetin; SEÇİLMİŞ KERİMOĞLU, Özlem; ÜNLÜ, Ali

The relationship between Polycystic ovary syndrome and vitamin D levels

Setenay Arzu YILMAZ, (Selçuk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya, Türkiye)

Sündüz Özlem ALTINKAYA, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Aydın, Türkiye)

Ayşegül KEBABÇILAR, (Selçuk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya, Türkiye)

Özlem SEÇİLMİŞ KERİMOĞLU, (Selçuk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya, Türkiye)

Aybike PEKİN TAZEGÜL, (Selçuk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya, Türkiye)

Sedat ABUŞOĞLU, (Selçuk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye)

Çetin ÇELİK, (Selçuk Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya, Türkiye)

Ali ÜNLÜ (Selçuk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye)

Türk Jinekoloji ve Obstetrik Derneği Dergisi

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Yıl: 2015 Cilt: 12 Sayı: 1 Sayfa Aralığı: 18 - 24 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship between Polycystic ovary syndrome and vitamin D levels

Öz:

Amaç: Bu çalışmadaki esas amacımız Polikistik over sendromu (PCOS) olan ve olmayan hastalarda, serum 25 hidroksi vitamin D (25-OH D) düzeyi ile klinik, metabolik ve hormonal parametreler arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Hastalar: 48 normal kilolu (vücut kitle index (VKİ) 19-24,99 kg/m2), 36 fazla kilolu (VKİ: 25-29,99 kg/m2) yeni tanısı konulmuş PCOSlu hasta ve 56 sağlıklı kontrol hastası (VKİ: 19-24,99 kg/m²) çalışmaya dahil edildi. Adetin 2. ile 5. günü arasında 10-12 saatlik açlık sonrası sabah 09:00da kan örnekleri alındı. Serum 25 hidroksi vitamin D (25-OH D), FSH, LH, E2, serbest testesteron (st), prolaktin, TSH, 17-OH progesteron, seks hormon bağlayıcı globulin (SHBG), açlık insulin, açlık glukoz, ve lipid profili değerlendirildi. Bulgular: 25-OH D düzeyi normal ve kilolu PCOSlu hastalarda da kontrol grubuna göre istatistiksel olarak anlamlı düşük düzeylerde bulundu (p<0,05, p<0,01 sırası ile). 25-OH D düzeyi ile bel çevresi, bel kalça oranı, serbest testesteron, modifiye Ferriman Galwey skoru arasında istatistiksel olarak anlamlı negatif korelasyon; SHBG ile pozitif korelasyon saptandı. Sonuç: PCOS, D vitamini eksikliği ile ilişkilidir.

Anahtar Kelime:

Konular: Cerrahi

Polikistik over sendromu ve D vitamini düzeyleri arasındaki ilişki

Öz:

Objective: The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS). Materials and Methods: Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m2) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m2) women with PCOS and 56 normal-weight controls participated in the study. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 am after an overnight fast. Circulating concentrations of 25-OH D, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, TSH, free testosterone, dehydroepiandrosterone sulphate (DHEA-SO4), 17-hydroxyprogesterone, sex hormonebinding globulin (SHBG), fasting insulin, fasting glucose, and lipid profile were assessed. Results: Normal weight (BMI 19-24.99 kg/m2) and overweight (BMI 25-29.99 kg/m2) women with PCOS were compared with normal-weight controls and lower 25-OH D levels were found in both PCOS groups (p<0.05 and p<0.01, respectively 25-OH D significantly negatively correlated with waist circumference (WC), waist-to-hip ratio (WHR), free testosterone and modified Ferriman-Gallwey scores, however, there was a positive correlation between 25-OH D and SHBG levels (p<0.05). Conclusion: Our findings suggest that PCOS is associated with hypovitaminosis D.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Carmina E, Lobo RA. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 1999;84:1897-9.
2. Wojciechowski P, Lipowska A, Rys P, Ewens KG, Franks S, Tan S, et al. Impact of FTOgenotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.Diabetologia 2012;55:2636-45.
3. Wild S, Pierpoint T, Jacobs H, McKeigue P. Long-termconsequences of polycystic ovary syndrome: results of a 31 yearfollow-upstudy. Hum Fertil (Camb) 2000;3:101-5.
4. Haoula Z, Salman M, Atiomo W. Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod 2012;27:1327-31. 5. Walters MR. Newly identified actions of the vitamin D endocrine system. Endocr Rev 1992;13:719-64.
6. Studzinski GP, McLane JA, Uskokovic MR. Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases. Crit Rev Eukaryot Gene Expr 1993;3:279-312.
7. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev 2008;66(10Suppl 2):153-64.
8. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 2010;121:297-300.
9. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81. 10. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insülin sensitivity. Nutr Res Rev 2009;22:82-92.
11. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res 2010;42:754-7.
12. Ranjzad F, Mahban A, Shemirani AI, Mahmoudi T, Vahedi M, Nikzamir A, et al. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. J Assist Reprod Genet 2011;28:225-32. 13. Franks S. Polycystic ovary syndrome. N Engl J Med 1995;333:853- 61.
14. Dale PO, Tanbo T, Vaaler S, Abyholm T. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations. Fertil Steril 1992;58:487-91.
15. Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism 2011;60:1475- 81.
16. Panidis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, et al. Serum parathyroid hormone concentrations are in creased in women with polycystic ovary syndrome.Clin Chem 2005;51:1691- 7.
17. Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insülin resistance, and the polycystic ovary syndrome. Fertil Steril 2010;93:1208-14.
18. Wehr E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, ObermayerPietsch B. Vitamin D-associated polymorphisms are related to insülin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol 2011;164:741-9.
19. Mazloomi S, Sharifi F, Hajihosseini R, Kalantari S, Mazloomzadeh S. Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome. ISRN Endocrinol 2012;2012:949427.
20. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insülin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006;114:577-83.
21. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, et al. Serum 25-hydroxyvitamin D concentrations in obese and onobese women with polycystic ovary syndrome. Arch Gynecol Obstet 2009;280:559-63.
22. Muscogiuri G, Policola C, Prioletta A, Sorice G, Mezza T, Lassandro A, et al. Low levels of 25(OH) D and insulin-resistance: 2 unrelated features or a cause-effect in PCOS? Clin Nutr 2012;31:476-80.
23. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol 2012;28:965-8.
24. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-7.
25. Wild RA, Vesely S, BeebeL,WhitsettT, OwenW. Ferriman Gallwey self scoring I: performance assessment in women with polycystic ovary syndrome. J Clin Endocrinol Metab2005;90:4112-4.
26. Legro RS, Castracane VD, Kauffman RP. Detecting insülin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv 2004;59:141-54.
27. Reha A. Uygulamalı Çok Değişkenli İstatistiksel Yöntemlere Giriş 1. Bölüm 7. Çoklu Doğrusal Regresyon, Çoklu Doğrusal Regresyon Modellerinde Değişken Seçimi. Nobel Yayın Dağıtım, Ankara, 2003:346.
28. Vittinghoff E, Glidden DV, Shiboski SC, McCulloch CE. Regression Methods in Biostatistics. Linear, Logistic, Survival and Repeated Measures Models. Chapter 5. Predictor Selection, Number of Predictors. Springer Science+Business Media, Inc. New York, 2005:149.
29. Stumpf WE, Denny ME. Vitamin D (soltriol), light, andreproduction. Am J Obstet Gynecol 1989;161:1375-84.
30. Isaia G, Giorgino R, Adami S. High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care 2001;24:1496.
31. Holecki M, Zahorska-Markiewicz B, Janowska J, Mizia-Stec K, ZakGotab A,Olszanecka-Glinianowicz M, et al. Osteoprotegerin--does it play a protective role in thepathogenesis of bone loss in obese perimenopausal women? Endokrynol Pol 2007;58:7-10.
32. Yanoff LB, Parikh SJ, Spitalnik A, Denkinger B, Sebring NG, Slaughter P, et al. The prevalence of hypovitaminosis D and second ary hyperparathyroidism in obese Black Americans. ClinEndocrinol 2006;64:523-9.
33. Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR. Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr 1981;34:2359-63.
34. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypo vitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 2009;161:575-82.
35. Selimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G, et al. The effect of vitamin D replacement therapy on insülin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest 2010;33:234-8.
36. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment onglucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011;34:757-63.

APA	YILMAZ S, ALTINKAYA S, KEBABÇILAR A, SEÇİLMİŞ KERİMOĞLU Ö, PEKİN TAZEGÜL A, ABUŞOĞLU S, celik c, ÜNLÜ A (2015). The relationship between Polycystic ovary syndrome and vitamin D levels. , 18 - 24.
Chicago	YILMAZ Setenay Arzu,ALTINKAYA Sündüz Özlem,KEBABÇILAR Ayşegül,SEÇİLMİŞ KERİMOĞLU Özlem,PEKİN TAZEGÜL Aybike,ABUŞOĞLU Sedat,celik cetin,ÜNLÜ Ali The relationship between Polycystic ovary syndrome and vitamin D levels. (2015): 18 - 24.
MLA	YILMAZ Setenay Arzu,ALTINKAYA Sündüz Özlem,KEBABÇILAR Ayşegül,SEÇİLMİŞ KERİMOĞLU Özlem,PEKİN TAZEGÜL Aybike,ABUŞOĞLU Sedat,celik cetin,ÜNLÜ Ali The relationship between Polycystic ovary syndrome and vitamin D levels. , 2015, ss.18 - 24.
AMA	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A The relationship between Polycystic ovary syndrome and vitamin D levels. . 2015; 18 - 24.
Vancouver	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A The relationship between Polycystic ovary syndrome and vitamin D levels. . 2015; 18 - 24.
IEEE	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A "The relationship between Polycystic ovary syndrome and vitamin D levels." , ss.18 - 24, 2015.
ISNAD	YILMAZ, Setenay Arzu vd. "The relationship between Polycystic ovary syndrome and vitamin D levels". (2015), 18-24.

APA	YILMAZ S, ALTINKAYA S, KEBABÇILAR A, SEÇİLMİŞ KERİMOĞLU Ö, PEKİN TAZEGÜL A, ABUŞOĞLU S, celik c, ÜNLÜ A (2015). The relationship between Polycystic ovary syndrome and vitamin D levels. Türk Jinekoloji ve Obstetrik Derneği Dergisi, 12(1), 18 - 24.
Chicago	YILMAZ Setenay Arzu,ALTINKAYA Sündüz Özlem,KEBABÇILAR Ayşegül,SEÇİLMİŞ KERİMOĞLU Özlem,PEKİN TAZEGÜL Aybike,ABUŞOĞLU Sedat,celik cetin,ÜNLÜ Ali The relationship between Polycystic ovary syndrome and vitamin D levels. Türk Jinekoloji ve Obstetrik Derneği Dergisi 12, no.1 (2015): 18 - 24.
MLA	YILMAZ Setenay Arzu,ALTINKAYA Sündüz Özlem,KEBABÇILAR Ayşegül,SEÇİLMİŞ KERİMOĞLU Özlem,PEKİN TAZEGÜL Aybike,ABUŞOĞLU Sedat,celik cetin,ÜNLÜ Ali The relationship between Polycystic ovary syndrome and vitamin D levels. Türk Jinekoloji ve Obstetrik Derneği Dergisi, vol.12, no.1, 2015, ss.18 - 24.
AMA	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A The relationship between Polycystic ovary syndrome and vitamin D levels. Türk Jinekoloji ve Obstetrik Derneği Dergisi. 2015; 12(1): 18 - 24.
Vancouver	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A The relationship between Polycystic ovary syndrome and vitamin D levels. Türk Jinekoloji ve Obstetrik Derneği Dergisi. 2015; 12(1): 18 - 24.
IEEE	YILMAZ S,ALTINKAYA S,KEBABÇILAR A,SEÇİLMİŞ KERİMOĞLU Ö,PEKİN TAZEGÜL A,ABUŞOĞLU S,celik c,ÜNLÜ A "The relationship between Polycystic ovary syndrome and vitamin D levels." Türk Jinekoloji ve Obstetrik Derneği Dergisi, 12, ss.18 - 24, 2015.
ISNAD	YILMAZ, Setenay Arzu vd. "The relationship between Polycystic ovary syndrome and vitamin D levels". Türk Jinekoloji ve Obstetrik Derneği Dergisi 12/1 (2015), 18-24.