Objective: To evaluate the treatment results of patients with monosymptomatic enuresis nocturna. Methods: 97 patients with monosymptomatic enuresis nocturna were included. First, motivation and behavioral treatment have been applied to the patients for 3 months. 60-120 mcg desmopressin has been applied to 79 patients who did not want to continue to the motivation and behavioral treatment or who did not have benefit from motivation and behavioral treatment or whose disease have relapsed. It is accepted as full response if the number of wetting decreases 90-100%, middle response decreases 50-90%, failed response decreases less than 50%. Treatment and relapse rates were evaluated based on the response to therapy at the time of controls. Results: Mean age of the patients was 7.75±1.96 (5-12) years. 20 of 97 (21%) patients who have taken motivation and behavioral treatment have been cured. Two (%10) of these patients diseases have relapsed. Desmopressin has been applied to79 patients who did not have benefit from motivation and behavioral treatment or whose diseases have relapsed. Full dryness has been provided in 36 (46%) patients who have taken desmopressin and came to the control visit. Middle response has been obtained in 22 (28%) patients. Failed response has been obtained in 21 (26%) patients. Relapse has been seen in case of quitting desmopressin in 35 (60%) patients who have benefit from desmopressin. Conclusion: Although, Desmopressin is the most preferred method in monosymptomatic enuresis nocturna, because of easy usage and fast response, relapse ratio is high following discontinuation of the drug.