The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease

Yılmaz, Mustafa; DEVEER, Mehmet; SÖZEN, Ayşe; Yılmaz, Nigar; HAZER, Derya Burcu; Cullu, Nesat

The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease

Mustafa YILMAZ, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Muğla, Türkiye)

Nigar YILMAZ, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Muğla, Türkiye)

Ayşe SÖZEN, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Muğla, Türkiye)

Mehmet DEVEER, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Muğla Türkiye)

Neşat ÇULLU, (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Muğla Türkiye)

Derya Burcu HAZER (Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Nöroşirürji, Anabilim Dalı, Muğla, Türkiye)

Journal of Neurological Sciences (Turkish)

6 1

Yıl: 2013 Cilt: 30 Sayı: 2 Sayfa Aralığı: 257 - 264 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease

Öz:

Giriş: Parkinson hastalarında 25-Hydroksi vitamin D (25(OH)-D), paratiroid hormon (PTH)ve bazal ganglion kalsifikasyonu (BGC) seviyelerini ve aralarındaki ilişkiyi araştırmayıamaçladık.Metod: Antakya Devlet Hastanesi Nöroloji kliniğine başvuran 32 parkinson hastası ve 32sağlıklı kişi çalışmaya dahil edildi. Serumda 25(OH)-D, PTH, kalsiyum (Ca++), fosfor (PO4),total protein, albumin seviyeleri saptandı. BGC'u tespit etmek için beyin tomoğrafisi (BT)kullanıldı. Parkinson hastaları olarak tedavi altındaki erken ve orta dönemdeki hastalar seçildi.Sonuç: Parkinson hastalarında 25(OH)-D seviyesi kontrol grubuna kıyasla anlamlı olarakdüşük tespit edildi (p<0.001). Parkinson hastalarında PTH seviyesi yüksekliği tespit edildiancak istatistiksel olarak anlamlı değildi (p>0.05). BGC, Parkinson hastaların üçünde (%9)varken, kontrol grubunda ikisinde (%6) tespit edildi. Parkinson hastalarında ve kontrolgrubunda BGC açısından istatistiksel fark tespit edilmedi. Parkinson hastalarında düşük25(OH)-D seviyesi ile PTH arasında korelasyon tespit edilmedi.Tartışma: Parkinson hastalarında 25 (OH)-D seviyesinin çok düşük miktarda olduğu ancak Dvitaminin metabolizmasında rol oynayan PTH seviyesinin değişmediği ve kalsiyummetabolizmasının bozulmasıyla oluşan BGC varlığının sağlıklı kişilere göre farklı olmadığıtespit edilmiştir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Bazal Ganglion Kalsifikasyonunun ve Parathorman, 25(OH)-D Düzeylerinin Parkinson Hastalığı ile İlişkisi

Öz:

Objective: This study aims to investigate the relationship between the levels of 25- Hydroxyvitamin D (25(OH)-D), parathyroid hormone (PTH) and basal ganglia calcification(BGC) in patients with Parkinson's disease (PD).Method: The study population consisted of 32 patients with PD who were admitted to theNeurology Clinic of Antakya State Hospital in 2010 as well as 32 healthy control subjects.Serum 25(OH)-D, PTH, calcium (Ca++), phosphorus (PO4), total protein, and albumin levelswere determined. Brain computed tomography (CT) scans were used to show BGC. Treatedand early-mid-stage patients were selected.Results: The level of 25(OH)-D in serum were lower in patients with PD than the controlgroup (p<0.001). The level of PTH was found higher in patients with PD, but it was notstatistically significant (p>0.05). BGC was present three patients (9%) with PD and twosubjects (6%) in the control group. The presence of BGC was not statistically significant inpatients with PD compared with the control group. There were no correlations between lower25 (OH)-D and PTH concentrations in patients with PD; however the level of PTH, whichplays a role in the vitamin D metabolism, was not found different, and the presence of BGC,which plays a role in the calcium metabolism, was not found different compared with healthysubjects.Conclusions: The low level of 25 (OH)-D should cause poor control of Ca++, PO4; howeverthe level of PTH and the presence of BGC were not different significantly.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yılmaz M, Yılmaz N, SÖZEN A, DEVEER M, Cullu N, HAZER D (2013). The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. , 257 - 264.
Chicago	Yılmaz Mustafa,Yılmaz Nigar,SÖZEN Ayşe,DEVEER Mehmet,Cullu Nesat,HAZER Derya Burcu The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. (2013): 257 - 264.
MLA	Yılmaz Mustafa,Yılmaz Nigar,SÖZEN Ayşe,DEVEER Mehmet,Cullu Nesat,HAZER Derya Burcu The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. , 2013, ss.257 - 264.
AMA	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. . 2013; 257 - 264.
Vancouver	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. . 2013; 257 - 264.
IEEE	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D "The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease." , ss.257 - 264, 2013.
ISNAD	Yılmaz, Mustafa vd. "The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease". (2013), 257-264.

APA	Yılmaz M, Yılmaz N, SÖZEN A, DEVEER M, Cullu N, HAZER D (2013). The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. Journal of Neurological Sciences (Turkish), 30(2), 257 - 264.
Chicago	Yılmaz Mustafa,Yılmaz Nigar,SÖZEN Ayşe,DEVEER Mehmet,Cullu Nesat,HAZER Derya Burcu The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. Journal of Neurological Sciences (Turkish) 30, no.2 (2013): 257 - 264.
MLA	Yılmaz Mustafa,Yılmaz Nigar,SÖZEN Ayşe,DEVEER Mehmet,Cullu Nesat,HAZER Derya Burcu The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. Journal of Neurological Sciences (Turkish), vol.30, no.2, 2013, ss.257 - 264.
AMA	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. Journal of Neurological Sciences (Turkish). 2013; 30(2): 257 - 264.
Vancouver	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease. Journal of Neurological Sciences (Turkish). 2013; 30(2): 257 - 264.
IEEE	Yılmaz M,Yılmaz N,SÖZEN A,DEVEER M,Cullu N,HAZER D "The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease." Journal of Neurological Sciences (Turkish), 30, ss.257 - 264, 2013.
ISNAD	Yılmaz, Mustafa vd. "The Relationship Basal Ganglia Calcification and Level Of 25(OH)-D and Parathyroid Hormone in Patients With Parkinson's Disease". Journal of Neurological Sciences (Turkish) 30/2 (2013), 257-264.