Yıl: 2013 Cilt: 4 Sayı: 3 Sayfa Aralığı: 216 - 218 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion

Öz:
Amaç: Akciğer kontüzyonlu ratların serumlarında adenozin deaminaz (ADA)izoenzimlerinin aktivitelerini araştırmayı amaçladık. Gereç ve Yöntem: On ikitane erkek wistar albino sıçanda toraks üzerine hareketli platform ile 50 cmyükseklikten bir silindirik ağırlık bırakılarak akciğer kontüzyonu oluşturuldu.Travmadan 24 saat (n=6) ve 72 saat (n=6) sonra sıçanlar öldürüldü. Kontrol (n=6) (travma uygulanmayan) ve travmatik sıçanların serumlarında ADAizoenzimleri ölçüldü. Bulgular: Bizim sonuçlarımız kontüzyon sonrası 72 saatte serum total ADA aktivitelerinde önemli derecede azalma olduğunu göstermiştir. Kontüzyon sonrası 24 ve 72 saatteki ADA1 aktivitesinde kontrolle karşılaştırıldığında önemli bir düşüş vardır. Diğer taraftan, 24 ve 72 saatte ADA2 aktivitesindeki artış istatistiksel olarak anlamlı değildir. Sonuç: Sonuç olarak, serum ADA2 izoenzimi akciğer kontüzyonunda inflamatuvar yanıt nedeniyle baskın izoenzim haline gelmiştir. Ancak serum ADA1 aktivitesini etkileyen düzenleyici mekanizmaları açıklamak için ileri çalışmalara ihtiyaç duyulmaktadır.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Akciğer Kontüzyonunda Serum Adenozin Deaminaz İzoenzimlerinin Değerlendirilmesi

Öz:
Aim: We aimed to investigate the activity of ADA isoenzymes in serum of ratswith lung contusion Material and Method: Lung contusion was induced intwelve male wistar albino rats by dropping a cylindrical weight from a heightof 50 cm with a mobile platform positioned over the thorax. Rats were killedat 24 hour (n=6) and 72 hour (n=6) after contusion. ADA isoenzymes weremeasured in serum traumatic and control (n=6) (uninjured) rats. Results: Ourresults indicated that serum total ADA activities were significantly decreasedat 72 h after contusion. There was a significant decreased in ADA1 activityat 24 and 72 h after contusion when compared with controls. On the otherhand, the increase in the ADA2 activity at 24 h and 72 h was not statisticallysignificant. Discussion: In conclusion, serum ADA2 became predominantisozyme because of the inflammatory response in the lung contusion.However, further studies are needed to elucidate the regulatory mechanismsthat effect the activity of serum ADA1.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Guven B, CAN M, Gokce M, SAYDAM Ö (2013). Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. , 216 - 218.
Chicago Guven Berrak,CAN Murat,Gokce Mertol,SAYDAM ÖZKAN Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. (2013): 216 - 218.
MLA Guven Berrak,CAN Murat,Gokce Mertol,SAYDAM ÖZKAN Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. , 2013, ss.216 - 218.
AMA Guven B,CAN M,Gokce M,SAYDAM Ö Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. . 2013; 216 - 218.
Vancouver Guven B,CAN M,Gokce M,SAYDAM Ö Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. . 2013; 216 - 218.
IEEE Guven B,CAN M,Gokce M,SAYDAM Ö "Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion." , ss.216 - 218, 2013.
ISNAD Guven, Berrak vd. "Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion". (2013), 216-218.
APA Guven B, CAN M, Gokce M, SAYDAM Ö (2013). Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. Journal of Clinical and Analytical Medicine, 4(3), 216 - 218.
Chicago Guven Berrak,CAN Murat,Gokce Mertol,SAYDAM ÖZKAN Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. Journal of Clinical and Analytical Medicine 4, no.3 (2013): 216 - 218.
MLA Guven Berrak,CAN Murat,Gokce Mertol,SAYDAM ÖZKAN Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. Journal of Clinical and Analytical Medicine, vol.4, no.3, 2013, ss.216 - 218.
AMA Guven B,CAN M,Gokce M,SAYDAM Ö Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. Journal of Clinical and Analytical Medicine. 2013; 4(3): 216 - 218.
Vancouver Guven B,CAN M,Gokce M,SAYDAM Ö Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion. Journal of Clinical and Analytical Medicine. 2013; 4(3): 216 - 218.
IEEE Guven B,CAN M,Gokce M,SAYDAM Ö "Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion." Journal of Clinical and Analytical Medicine, 4, ss.216 - 218, 2013.
ISNAD Guven, Berrak vd. "Evaluating of Serum Adenosine Deaminase Isoenzymes in Lung Contusion". Journal of Clinical and Analytical Medicine 4/3 (2013), 216-218.