Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı
Yıl: 2015 Cilt: 61 Sayı: 4 Sayfa Aralığı: 358 - 365 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı
Öz: Romatizmal hastalıkların çoğu doğurganlık çağındaki kadınları etkilemektedir. Gebelik süresince romatoid artrit gibi bazı inflamatuvar artritler remisyona girerken bazı hastalarda ise gebeliğin hastalık aktivitesini arttırdığı iyi bilinmektedir. Maalesef ki, gebelik sırasında romatizmal hastalığın alevlenmesi fetusun kaydedilmesine, intrauterin gelişme geriliğine ya da prematür doğum yapılmasına yol açabilir. Ayrıca, gebelerde aktif hastalığı kontrol altına almak için antiromatizmal ilaçların kullanılması da fetal komplikasyonlara neden olabilir. Bu derlemede ilk olarak gebeliğin hastalık üzerine ve hastalığın fetus üzerine etkileri tartışılmıştır. Ardından biyolojik olan ve olmayan hastalık modifiye edici antiromatizmal ilaçların fertilite, gebelik ve laktasyon üzerine etkileri özetlenmiştir. Romatizmal hastalıklarla uğraşan hekimlerin bu ilaçların potansiyel yan etkilerinden haberdar olması ve bu ilaçların gebelik ve emzirme döneminde kullanılması durumunda ortaya çıkacak riskleri ve yararları hastaları ile ayrıntılı olarak görüşmesi gereklidir
Anahtar Kelime: Konular:
Rheumatic Diseases and Their Treatment with Anti-Rheumatic Drugs during Pregnancy
Öz: Many rheumatic diseases affect women of childbearing age. It is well known that during pregnancy, some patients with inflammatory arthritis such as rheumatoid arthritis go into remission, whereas in others, pregnancy aggravates disease activity. Unfortunately, the flares of rheumatic diseases during pregnancy may result in fetal loss, intrauterine growth retardation, and premature delivery. Furthermore, during pregnancy, anti-rheumatic drugs used to control disease activity may lead to fetal complications. In this review, the effects of pregnancy on the disease and the effects of disease on the fetus are discussed first. The effects of biological and non-biological disease-modifying anti-rheumatic drugs on fertility, pregnancy, and lactation are then summarized. Physicians dealing with rheumatic diseases need to be aware of the potential adverse effects of these medications and discuss the risks and benefits of drugs during pregnancy and lactation with their patients in detail
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
- Gayed M, Gordon C. Pregnancy and rheumatic diseases. Rheuma- tology (Oxford) 2007;46:1634-40. [CrossRef]
- Nelson JL, Ostensen M. Pregnancy and rheumatoid arthritis. Rhe- um Dis Clin North Am 1997;23:195-212. [CrossRef]
- Østensen M, Förger F, Nelson JL, Schuhmacher A, Hebisch G, Villiger PM. Pregnancy in patients with rheumatic diseases: anti- inflammatory cytokines increas in pregnancy and decrease post partum. Ann Rheum Dis 2005;64:839-44. [CrossRef]
- de Man YA, Dolhain RJ, van de Geijn FE, Willemsen SP, Hazes JM. Disease activity of rheumatoid arthritis during pregnancy: result from a nation- wide prospective study. Arthritis Rheum 2008;59:1241-8. [CrossRef]
- Brennan P, Bankhead C, Silman A, Symmons D. Oral contra- ceptives and rheumatoid arthritis: results from a primary ca- re-based incident case-control study. Semin Arthritis Rheum 1997;26:817-23. [CrossRef]
- Brouwer J, Hazes JM, Laven JS, Dolhain RJ. Fertility in women with rheumatoid arthritis: influence of disease activity and medi- cation. Ann Rheum Dis 2014 May 15. doi: 10.1136/annrheum- dis-2014-205383. [CrossRef]
- Chen JS, Ford JB, Roberts CL, Simpson JM, March LM. Pregnancy outcomes in women with juvenile idiopathic arthritis: a population- based study. Rheumatology (Oxford) 2013;52:1119-25. [CrossRef]
- Hatemi G, Hamuryudan V. Gebelik ve romatizmal hastalıklar. Klinik Gelişim 2008;21:128-36.
- Østensen M, Fuhrer L, Mathieu R, Seitz M, Villiger PM. A pros- pective study of pregnant patients with rheumatoid arthritis and ankylosing spondylitis using validated clinical instruments. Ann Rheum Dis 2004;63:1212-7. [CrossRef]
- Lui NL, Haroon N, Carty A, Shen H, Cook RJ, Shanmugarajah S, et al. Effect of pregnancy on ankylosing spondylitis: a case-control study. J Rheumatol 2011;38:2442-4. [CrossRef]
- Gromnica-Ihle E, Ostensen M. Pregnancy in patients with rheuma- toid arthritis and inflammatory rheumatic diseases. Z Rheumatol 2006;65:209-16. [CrossRef]
- Surita FG, Parpinelli MA, Yonehara E, Krupa F, Cecatti JG. Systemic lupus eritematosus and pregnancy: clinical evolution, maternal and perinatal outcomes and placental findings. Sao Paulo Med J 2007;125:91-5. [CrossRef]
- Clowse ME. Lupus activity in pregnancy. Rheum Dis Clin North Am 2007;33:237-52. [CrossRef]
- Doria A, Iaccarino L, Ariente S, Ghirardello A, Zampieri S, Ram- pudda ME, et al. Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases. Reprod Toxicol 2006;22:234-41. [CrossRef]
- Huong DL, Wechsler B, Vauthier-Brouzes D, Beaufils H, Lefebv- re G, Piette JC. Pregnancy in past or present lupus nephritis: a study of 32 pregnancies from a single centre. Ann Rheum Dis 2001;60:599-604. [CrossRef]
- Andreoli L, Bazzani C, Taraborelli M, Reggia R, Lojacono A, Brucato A, et al. Pregnancy in autoimmune rheumatic diseases: the impor- tance of counselling for old and new challanges. Autoimmun Rev 2010;10:51-4. [CrossRef]
- Gordon C. Pregnancy and autoimmune diseases. Best Pract Res Clin Rheumatol 2004;18:359-79. [CrossRef]
- Brucato A, Doria A, Frassi M, Castellino G, Franceschini F, Faden D, et al. Pregnancy outcome in 100 women with autoimmune di- seases and anti-Ro/SSA antibodies: a prospective controlled study. Lupus 2002;11:716-21. [CrossRef]
- Buyon JP, Clancy RM. Neonatal lupus syndrome. Curr Opin Rheu- matol 2003;15:535-41. [CrossRef]
- Dhar JP, Sokol RJ. Lupus and pregnancy: complex yet manageable. Cllin Med Res 2006;4:310-21. [CrossRef]
- Jain V, Gordon C. Managing pregnancy in inflammatory rheumato- logical diseases. Arthritis Res Ther 2011;13:206. [CrossRef]
- Ramsey-Goldman R. Effect of pregnancy on the vasculitides. Scand J Rheumatol Suppl 1998;107:116-7.
- Noel N, Wechsler B, Nizard J, Costedoat-Chalumeau N, Boutin du LT, Dommergues M, et al. Behçet's disease and pregnancy. Arthritis Rheum 2013;65:2450-6. [CrossRef]
- Iskender C, Yasar O, Kaymak O, Yaman ST, Uygur D, Danisman N. Behçet's disease and pregnancy: a retrospective analysis of co- urse of disease and pregnancy outcome. J Obstet Gynaecol Res 2014;40:1598-602. [CrossRef]
- Miniati I, Guiducci S, Mecacci F, Mello G, Matucci-Cerinic M. Preg- nancy in systemic sclerosis. Rheumatology (Oxford) 2008;47(Suppl 3):iii16-8. [CrossRef]
- Sten VD. Pregnancy in scleroderma. Rheum Dis Clin North Am 2007;33:345-58. [CrossRef]
- Haga HJ, Gjesdal CG, Irgens LM, Ostensen M. Reproduction and gyna- ecological manifestations in women with primary Sjögren's syndrome: a case-control study. Scand J Rheumatol 2005;34:45-8. [CrossRef]
- De Carolis S, Salvi S, Botta A, Garofalo S, Garufi C, Ferrazzani S, et al. The impact of primary Sjogren's syndrome on pregnancy outcome: our series and review of the literature. Autoimmun Rev 2014;13:103-7. [CrossRef]
- Mecacci F, Pieralli P, Bianchi B, Paidas MJ. The impact of autoim- mune disorders and adverse pregnancy outcome. Semin Perinatol 2007;31:223-6. [CrossRef]
- Silva CA, Sultan SM, Isenberg DA. Pregnancy outcome in adult- onset idiopathic infammatory myopathy. Rheumatology (Oxford) 2003;42:1168-72. [CrossRef]
- Váncsa A, Ponyi A, Constantin T, Zeher M, Dankó K. Pregnancy outcome in idiopathic inflammatory myopathy. Rheumatol Int 2007;27:435-9. [CrossRef]
- Yasar O, İskender C, Kaymak O, Yaman ST, Uygur D, Danışman N. Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever. J Matern Fetal Neonatal Med 2014;27:733-6. [CrossRef]
- Ben-Chetrit E, Levy M. Reproductive system in familial Mediterrane- an fever: an overview. Ann Rheum Dis 2003;62:916-9. [CrossRef]
- Ofir D, Levy A, Wiznitzer A, Mazor M, Sheiner E. Familial Mediterrane- an fever during pregnancy: an independent risk factor for preterm de- livery. Eur J Obstet Gynecol Reprod Biol 2008;141:115-8. [CrossRef]
- Livneh A, Cabili S, Zemen D, Rabinovitch O, Pras M. Effect of preg- nancy on renal function in amylodiosis of familial Mediterranean fever. J Rheumatol 1993;20:1519-23.
- Janssen NM, Genta MS. The effects of immunosuppressive and an- ti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med 2000;160:610-9. [CrossRef]
- Temprano KK, Bandlamudi R, Moore TL. Antirheumatic drugs in preg- nancy and lactation. Semin Arhritis Rheum 2005;35:112-21. [CrossRef]
- Park-Wyllei L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hun- nisett L, et al. Birth defects after maternal exposure to corticostero- ids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000;62:385-92. [CrossRef]
- Costedoat-Chalumeau N, Amoura Z, Duhaut P, Huong DL, Sebbo- ugh D, Wechsler B, et al. Safety of hydroxychloroquine in preg- nant patients with connective tissue disease. Arthritis Rheum 2003;48:3207-11. [CrossRef]
- Diav-Citrin O, Shechtman S, Schwartz V, Avgil-Tsadok M, Finkel-Pe- karsky V, Wajnberg R, et al. Pregnancy outcome after in utero expo- sure to colchicine. Am J Obstet Gynecol. 2010;203:e1-6. [CrossRef]
- Saag KG, Teng GG, Patkar NM, Anuntiyo J, Finney C, Curtis JR, et al. American College of Rheumatology 2008 Recommenda- tions fort he use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum 2008;59:762-84. [CrossRef]
- Carter JD, Ladhani A, Ricca LR, Valeriano J, Vasey FB. A safety as- sessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database. J Rheumatol 2009;36:635-41. [CrossRef]
- Crijns HJ, Jentink J, Garne E, Gispen-de Wied CC, Straus SM, de Jong-van den Berg LT; EUROCAT Working Group. The distribution of congenital anomalies within the VACTERL association among tu- mor necrosis factor antagonist-exposed pregnancies is similar to the general population. J Rheumatol 2011;38:1871-4. [CrossRef]
- Kane S, Ford J, Cohen R, Wagner S. Absence of infliximab in in- fants and breast milk from nursing mothers receiving therapy for Crohn's disease before and after delivery. J Clin Gastroenterol 2009;43:613-6. [CrossRef]
- Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Du- binsky MC. Case report: evidence for transplacental transfer of ma- ternally administered infliximab to the newborn. Clin Gastroenterol Hepatol 2006;4:1255-8. [CrossRef]
- Ostensen M, Förger F. Treatment with biologics of preg- nant patients with rheumatic diseases. Curr Opin Rheumatol 2011;22:293-8. [CrossRef]
- Murashima A, Watanabe N, Ozawa N, Saito H, Yamaguchi K. Eta- nercept during pregnancy and lactation in a patient with rheuma- toid arthritis: drug levels in maternal serum, cord blood, breast milk and infant's serum. Ann Rheum Dis 2009;68:1793-4. [CrossRef]
- Ben-Horin S, Yavzori M, Katz L, Picard O, Fudim E, Chowers Y, et al. Adalimumab level in breast milk of a nursing mother. Clin Gastro- enterol Hepatol 2010;8:475-6. [CrossRef]
- Ostensen M. Safety issues of biologics in pregnant patients with rheumatic diseases. Ann N Y Acad Sci 2014;1317:32-8. [CrossRef]
- Martin PL, Oneda S, Treacy G. Effects of an anti-TNF-alpha monoc- lonal antibody, administered throughout pregnancy and lactation, on the development of the macaque immune system. Am J Reprod Immunol 2007;58:138-49. [CrossRef]
- Khan N, Asim H, Lichtenstein GR. Safety of anti-TNF therapy in inf- lammatory bowel disease during pregnancy. Expert Opin Drug Saf 2014;13:1699-708. [CrossRef]
- Chakravarty EF, Murray ER, Kelman A, Farmer P. Pregnancy outcomes following maternal exposyre to rituximab. Blood 2011;117:1499-506. [CrossRef]
- Berger C, Recher M, Steiner U, Hauser TM. A patient's wish: anakin- ra in pregnancy. Ann Rheum Dis 2009;68:1794-5. [CrossRef]
- Fisher-Betz RC, Specker C, Schneider M. Succesful outcome of two pregnancies in patients with adult-onset Still's disease trea- ted with IL-1 receptor antagonist (anakinra). Clin Exp Rheumatol 2011;29:1021-3.
- Pham T, Claudepierre P, Constantin A, de Bandt M, Fautrel B, Gos- sec L, et al. Tocilizumab: therapy and safety management. Joint Bone Spine 2010;77:3-100. [CrossRef]
| APA | BORMAN P, ÖZDEMİR O (2015). Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. , 358 - 365. |
| Chicago | BORMAN Pınar,ÖZDEMİR Oya Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. (2015): 358 - 365. |
| MLA | BORMAN Pınar,ÖZDEMİR Oya Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. , 2015, ss.358 - 365. |
| AMA | BORMAN P,ÖZDEMİR O Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. . 2015; 358 - 365. |
| Vancouver | BORMAN P,ÖZDEMİR O Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. . 2015; 358 - 365. |
| IEEE | BORMAN P,ÖZDEMİR O "Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı." , ss.358 - 365, 2015. |
| ISNAD | BORMAN, Pınar - ÖZDEMİR, Oya. "Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı". (2015), 358-365. |
| APA | BORMAN P, ÖZDEMİR O (2015). Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 61(4), 358 - 365. |
| Chicago | BORMAN Pınar,ÖZDEMİR Oya Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 61, no.4 (2015): 358 - 365. |
| MLA | BORMAN Pınar,ÖZDEMİR Oya Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.61, no.4, 2015, ss.358 - 365. |
| AMA | BORMAN P,ÖZDEMİR O Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2015; 61(4): 358 - 365. |
| Vancouver | BORMAN P,ÖZDEMİR O Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2015; 61(4): 358 - 365. |
| IEEE | BORMAN P,ÖZDEMİR O "Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 61, ss.358 - 365, 2015. |
| ISNAD | BORMAN, Pınar - ÖZDEMİR, Oya. "Gebelik Döneminde Romatizmal Hastalıklar ve Antiromatizmal İlaç Kullanımı". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 61/4 (2015), 358-365. |
