Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever

ERTÜRK, AYŞE; CÜRE, Erkan; YÜCE, Süleyman; PARLAK, Emine; ÖZKURT, Zülal; CÜRE, Medine Cumhur

Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever

Ayşe ERTÜRK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Rize, Türkiye)

Erkan CÜRE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Emine PARLAK, (Atatürk Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Erzurum, Turkey)

Medine Cumhur CÜRE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Biyokimya Ana Bilim Dalı, Rize, Türkiye)

Süleyman YÜCE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Zülal ÖZKURT (Atatürk Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Erzurum, Turkey)

Journal of Microbiology and Infectious Diseases

2 0

Yıl: 2015 Cilt: 5 Sayı: 02 Sayfa Aralığı: 51 - 56 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever

Öz:

Amaç: Kırım-Kongo Kanamalı Ateşi (KKHA) virüsü, Bunyaviridae ailesine üye Nairovirus olup insanlarda ciddi hastalığa neden olur. KKKA enfeksiyonunda pansitopeni, organ yetersizliği ve yaygın damar-içi pıhtılaşma ortaya çıkabilir. Bu çalışmanın amacı, ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR)'nda bir değişiklik olup olmadığını ve bu parametrelerin hastanede kalış süresi için prediktör olup olamayacağını belirlemektir.Yöntem: Toplam 50 KKHA hastalığı bulunan (27 M ve 23 F) ve benzer yaş grubunda toplam 47 (27 M ve 20 F) sağlıklı birey çalışmaya alındı. Hematolojik ve biyokimyasal testleri ile C-reaktif protein (CRP), hasta ve kontrollerde çalışıldı. Hastanede kalış süresi üzerinde bağımsız prediktörleri belirlemek amacıyla çok değişkenli lojistik regresyon analizi yapıldı.Bulgular: MPV, hastalarda kontrollerden daha yüksek [8.4 (min / maks 6,4-9,4) fL vs 7.0 (min/maks 6,0-8,7) fL, p <0.001] idi. NLR ve PLR her iki grupta benzerdi. Hastanede kalış süresi prediktörleri: düşük beyaz kan hücreleri (WBC) ve trombosit sayısı (p <0.001 ve p=0.002 sırasıyla), bunlar yanı sıra uzamış protrombin zamanı (PT) (p=0.013), yüksek kreatinin (p=0.033) ve glukoz (p=0.044) düzeyleri olarak saptandı.Sonuç: MPV hasta grubunda daha yüksek olup NLR ve PLR oranları kontrol grubu ile benzerdi. MPV, NLR ve PLR hastanede kalış uzunluğu belirleyicisi olarak tespit edilmedi. Ancak, azalmış lökosit ve trombosit sayımı ile birlikte uzamış PT, artmış kreatinin ve glukoz düzeyleri, hospitalizasyon süresini predikte ettiği bulundu

Anahtar Kelime:

Konular: Hematoloji

Kırım-Kongo Hemorajik Ateşli Hastalarda Ortalama Trombosit Hacmi ve Nötrofil/Lenfosit Oranının Prognostik Değeri

Öz:

Objective: Crimean-Congo hemorrhagic fever (CCHF) virus, a Nairovirus within the family Bunyaviridae, causes severe disease in humans. Pancytopenia, organ failures and disseminated intravascular coagulation may occur as a result of CCHF infection. The aim of this study was to determine whether there is a change in the mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), and whether these might be predictors for the duration of hospitalization.Methods: A total of 50 CCHF patients (27 M and 23 F) and a similar age group of 47 healthy individuals (27 M and 20 F) were included in the study. Hematologic and biochemical tests inclusive of C-reactive protein were conducted on patients and controls. To determine the independent predictors of the duration of hospitalization, a multivariate logistic regression analysis was performed.Results: The MPV was higher in patients than that of the controls [8.4 (min/max 6.4-9.4) fL vs. 7.0 (min/max 6.0-8.7) fL, p<0.001]. The NLR and PLR were similar in both groups. The predictors of the length of hospitalization included decreased white blood (WBC) cell and platelet counts (p<0.001 and p=0.002, respectively), together with elevated prothrombin time (PT) (p=0.013) creatinine (p=0.033) and glucose levels (p=0.044). Conclusion: The MPV was higher in patients but NLR and PLR were similar in both groups. The MPV, NLR and PLR did not serve as predictors of hospitalization length. However, elevation of PT, creatinine, glucose, along with decreased WBC and platelets counts were found to be predictors of hospitalization period. J Microbiol Infect Dis 2015;5(2): 51-56

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERTÜRK A, CÜRE E, PARLAK E, CÜRE M, YÜCE S, ÖZKURT Z (2015). Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. , 51 - 56.
Chicago	ERTÜRK AYŞE,CÜRE Erkan,PARLAK Emine,CÜRE Medine Cumhur,YÜCE Süleyman,ÖZKURT Zülal Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. (2015): 51 - 56.
MLA	ERTÜRK AYŞE,CÜRE Erkan,PARLAK Emine,CÜRE Medine Cumhur,YÜCE Süleyman,ÖZKURT Zülal Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. , 2015, ss.51 - 56.
AMA	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. . 2015; 51 - 56.
Vancouver	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. . 2015; 51 - 56.
IEEE	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z "Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever." , ss.51 - 56, 2015.
ISNAD	ERTÜRK, AYŞE vd. "Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever". (2015), 51-56.

APA	ERTÜRK A, CÜRE E, PARLAK E, CÜRE M, YÜCE S, ÖZKURT Z (2015). Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, 5(02), 51 - 56.
Chicago	ERTÜRK AYŞE,CÜRE Erkan,PARLAK Emine,CÜRE Medine Cumhur,YÜCE Süleyman,ÖZKURT Zülal Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases 5, no.02 (2015): 51 - 56.
MLA	ERTÜRK AYŞE,CÜRE Erkan,PARLAK Emine,CÜRE Medine Cumhur,YÜCE Süleyman,ÖZKURT Zülal Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, vol.5, no.02, 2015, ss.51 - 56.
AMA	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases. 2015; 5(02): 51 - 56.
Vancouver	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases. 2015; 5(02): 51 - 56.
IEEE	ERTÜRK A,CÜRE E,PARLAK E,CÜRE M,YÜCE S,ÖZKURT Z "Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever." Journal of Microbiology and Infectious Diseases, 5, ss.51 - 56, 2015.
ISNAD	ERTÜRK, AYŞE vd. "Prognostic value of mean platelet volume and neutrophil to lymphocyte ratio in patients with Crimean-Congo Hemorrhagic Fever". Journal of Microbiology and Infectious Diseases 5/02 (2015), 51-56.