Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis

ÖZYILMAZ, Filiz; Tokuç, Burcu; TAŞTEKİN, Ebru; Guler, Beril; CAN, NURAY

Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis

Beril GÜLER, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Patoloji, Anabilim Dalı, İstanbul, Türkiye)

Filiz ÖZYILMAZ, (Trakya Üniversitesi, Tıp Fakültesi, Pataloji Anabilim Dalı, Edirne, Türkiye)

Burcu TOKUÇ, (Trakya Üniversitesi Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Edirne, Türkiye)

Nuray CAN, (Trakya Üniversitesi, Tıp Fakültesi, Pataloji Anabilim Dalı, Edirne, Türkiye)

Ebru TAŞTEKİN (Trakya Üniversitesi, Tıp Fakültesi, Pataloji Anabilim Dalı, Edirne, Türkiye)

Balkan Medical Journal

1 0

Yıl: 2015 Cilt: 32 Sayı: 4 Sayfa Aralığı: 388 - 396 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis

Öz:

Background: Gastrointestinal stromal tumors (GIST) have KIT or platelet-derived growth factor receptor ? (PDGFR?) mutations affecting receptor tyrosine ki-nase activity and do not benefit from classic treatment regimens.Aims: The aim of this study was to review the al-gorithm that may be followed for the diagnosis and differential diagnosis in GISTs by investigating the histomorphological parameters and expression charac-teristics of classical immunohistochemical antibodies used in routine tests in addition to DOG1 expression.Study Design: Diagnostic accuracy study.Methods: We reevaluated the histological and immu-nohistochemical parameters of 37 GISTs. The standard immunohistochemical diagnosis and differential diag-nosis panel antibodies (CD117, PDGFR?, CD34, vi-mentin, desmin, SMA, S-100, and Ki67) were studied on the tumor sections. We also used the popular marker DOG1 antibody with accepted sensitivity for GISTs in recent years and the PDGFR? immune marker for which the benefit in routine practice is discussed.Results: Classification according to progressive dis-ease risk groups of the 37 cases revealed that 54% were in the high risk, 19% in the moderate risk, 16% in the low risk, 8% in the very low risk and 8% in the no risk group.Cytological atypia, necrosis, mucosal invasion and the Ki67 index were found to be related to the progressive disease risk groups of the tumors (p<0.05).Positive immunoreaction was observed with CD117 and PDGFR? in all GISTs in the study (100%). Posi-tivity with the DOG1 antibody was found in 33 (89%) cases. CD34 was positive in 62% (23) of the cases.Conclusion: The CD117 antibody still plays a key role in GIST diagnosis. However, the use of DOG1 and PDGFR? antibodies combined with CD117 as sensitive markers can be beneficial

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Guler B, ÖZYILMAZ F, Tokuç B, CAN N, TAŞTEKİN E (2015). Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. , 388 - 396.
Chicago	Guler Beril,ÖZYILMAZ Filiz,Tokuç Burcu,CAN NURAY,TAŞTEKİN Ebru Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. (2015): 388 - 396.
MLA	Guler Beril,ÖZYILMAZ Filiz,Tokuç Burcu,CAN NURAY,TAŞTEKİN Ebru Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. , 2015, ss.388 - 396.
AMA	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. . 2015; 388 - 396.
Vancouver	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. . 2015; 388 - 396.
IEEE	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E "Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis." , ss.388 - 396, 2015.
ISNAD	Guler, Beril vd. "Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis". (2015), 388-396.

APA	Guler B, ÖZYILMAZ F, Tokuç B, CAN N, TAŞTEKİN E (2015). Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. Balkan Medical Journal, 32(4), 388 - 396.
Chicago	Guler Beril,ÖZYILMAZ Filiz,Tokuç Burcu,CAN NURAY,TAŞTEKİN Ebru Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. Balkan Medical Journal 32, no.4 (2015): 388 - 396.
MLA	Guler Beril,ÖZYILMAZ Filiz,Tokuç Burcu,CAN NURAY,TAŞTEKİN Ebru Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. Balkan Medical Journal, vol.32, no.4, 2015, ss.388 - 396.
AMA	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. Balkan Medical Journal. 2015; 32(4): 388 - 396.
Vancouver	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis. Balkan Medical Journal. 2015; 32(4): 388 - 396.
IEEE	Guler B,ÖZYILMAZ F,Tokuç B,CAN N,TAŞTEKİN E "Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis." Balkan Medical Journal, 32, ss.388 - 396, 2015.
ISNAD	Guler, Beril vd. "Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis". Balkan Medical Journal 32/4 (2015), 388-396.