Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats
Yıl: 2015 Cilt: 31 Sayı: 3 Sayfa Aralığı: 113 - 117 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats
Öz: Amaç: Malnütrisyon gastrointestinal sistemde yara iyileşmesini etkiler. Malnütrisyon nedeniyle azalan kolonik anastomoz iyileşmesi, preoperatif beslenme desteği ile olumlu yönde değişmektedir. Literatürde, malnütrisyon durumunda preoperatif nütrisyon desteğinin kolon anastomoz iyileşmesi üzerine etkileri bugüne kadar tek bir deneysel çalışmada incelenmiştir. Konuyla ilgili verileri artırmak amacıyla, preoperatif nütrisyon desteğinin malnütrisyonlu ratlardaki kolon anastomozu iyileşmesine etkisini değerlendirmek için deneysel bir çalışma planlandı. Gereç ve Yöntemler: On sekiz adet, erkek, wistar cinsi albino rat 3 gruba ayrıldı; kontrol grubu (K), 21 gün boyunca ad libitum beslendi; malnütrisyon grubu (M), 21 gün boyunca kontrol grubunun günlük tükettiği gıdanın %50'si ile beslenerek malnütrisyon gelişmesi sağlandı; preoperatif beslenme grubu (P), 21 gün boyunca kontrol grubunun günlük tükettiği gıdanın %50'si ile beslenerek malnütrisyon gelişmesi sağlandı ve 21 günün sonunda 7 gün süre ile ad libitum beslenenerek preoperatif beslenme desteği verilmiş oldu. 21. günün sonunda (K ve M) ve 28. günün sonunda (P) ratlara kolonik transeksiyon ve uçuca anastomoz yapıldı. Postoperatif 4. günde anastomoz patlama basıçları ölçülerek ratlar sakrifiye edildi ve doku hidroksiprolin düzeylerinin tayini için örnek alındı. Bulgular: K grubu ratlarda anastomoz patlama basıncı M grubu ve P grubu ratlara kıyasla anlamlı oranda yüksek (p<0,05), P grubu ratlarda M grubu ratlara kıyasla anlamlı oranda yüksek saptandı (p<0,05). Doku hidroksiprolin dü- zeyleri P grubu ratlarda M ve K grubu ratlara kıyasla anlamlı oranda yüksek saptandı (p<0,05). Sonuç: Yedi günlük preoperatif beslenme desteği ile kolonik anastomoz iyileşmesi ve kollajen sentezi artmakta ve kontrol grubuna yakın değerler elde edilmektedir.
Anahtar Kelime: Konular:
Malnütrisyon oluşturulan ratlarda, preoperatif beslenmenin, kolon anastomoz iyileşmesi üzerine etkisi
Öz: Objective: It has been proven that malnutrition increases postoperative morbidity and mortality, and it may also negatively affect wound healing in the gastrointestinal tract. In the literature, there is only one study evaluating the effects of preoperative nutritional support on colonic anastomotic healing under malnourished conditions. In order to improve the data on this topic, an experimental study was planned to evaluate the effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Material and Methods: The study included 18 male Wistar albino rats divided into 3 groups. The control (C) group was fed ad libitum for 21 days. The malnutrition (M) group and preoperative nutrition (P) group were given 50% of the daily food consumed by the rats in Group C for 21 days to induce malnutrition. At the end of 21 days, Group P was fed ad libitum for 7 days (preoperative nutritional support). Colonic transection and end-to-end anastomosis was performed at 21 days in Group C and Group M and at 28 days in Group P. The rats were sacrificed at postoperative 4 days, anastomotic bursting pressure was measured, and samples were taken to analyze tissue hydroxyproline levels. Results: Anastomotic bursting pressure was significantly higher in Group C than in Group M and Group P (p<0.05), and it was significantly higher in Group P than in Group M (p<0.05). Tissue hydroxyproline levels in Group P were found to be significantly higher than those in Group M and Group C (p<0.05). Conclusion: One week of preoperative nutritional support increases collagen synthesis in the colon and positively affects anastomotic healing under malnourished conditions.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Malone DL, Genuit T, Tracy JK, Gannon C, Napolitano LM. Surgical site infections: reanalysis of risk factors. J Surg Res 2002; 103: 89- 95. [CrossRef]
- Correia MI, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a mul- tivariate model analysis. Clin Nutr 2003; 22: 235-239. [CrossRef]
- Sungurtekin H, Sungurtekin U, Balci C, Zencir M, Erdem E. The in- fluence of nutritional status on complications after major intraab- dominal surgery. J Am Coll Nutr 2004; 23: 227-232. [CrossRef]
- Schiesser M, Müller S, Kirchhoff P, Breitenstein S, Schäfer M, Cla- vien PA. Assessment of a novel screening score for nutritional risk in predicting complications in gastro-intestinal surgery. Clin Nutr 2008; 27: 565-570. [CrossRef]
- Ljungqvist O, De Man F. Under nutrition: a major health problem in Europe. Nutr Hosp 2009; 24: 368-370.
- Irvin TT, Hunt TK. Effect of malnutrition on colonic healing. Ann Surg 1974; 180: 765-772. [CrossRef]
- Ward MW, Danzi M, Lewin MR, Rennie MJ, Clark CG. The effects of subclinical malnutrition and refeeding on the healing of experimen- tal colonic anastomoses. Br J Surg 1982; 69: 308-310. [CrossRef]
- Law NW, Ellis H. Revised model for the study of colonic anasto- motic healing in protein malnourished rats. Eur Surg Res 1989; 21: 218-223. [CrossRef]
- Detsky AS, Baker JP, O'Rourke K, Goel V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med 1987; 107: 195-203. [CrossRef]
- Von Meyenfeldt MF, Meijerink WJ, Rouflart MM, Builmaassen MT, Soeters PB. Perioperative nutritional support: a randomised clini- cal trial. Clin Nutr 1992; 11: 180-186. [CrossRef]
- Klein S, Kinney J, Jeejeebhoy K, Alpers D, Hellerstein M, Murray M, et al. Nutrition support in clinical practice: review of published data and recommendations for future research directions. Na- tional Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition. JPEN 1997; 21: 133-156. [CrossRef]
- Gonçalves CG, Groth AK, Ferreira M, Matias JE, Coelho JC, Campos AC. Influence of pre-operative feeding on the healing of colonic anastomoses in malnourished rats. JPEN 2009; 33: 83-89. [CrossRef]
- Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996; 29: 225-229. [CrossRef]
- Zaizen Y, Ford EG, Costin G, Atkinson JB. Stimulation of wound bursting strength during protein malnutrition. J Surg Res 1990; 49: 333-336. [CrossRef]
- Ikeuchi D, Onodera H, Aung T, Kan S, Kawamoto K, Imamura M, et al. Correlation of tensile strength with bursting pressure in the evaluation of intestinal anastomosis. Dig Surg 1999; 16: 478-485. [CrossRef]
- Mukerjee P, Mepham JA, Wapnick S, Datta BN, Cox AG. The effect of protein deprivation on alimentary healing. J Surg Res 1969; 9: 283-288. [CrossRef]
- Weimann A, Braga M, Harsanyi L, Laviano A, Ljungqvist O, Soeters P, et al. ESPEN guidelines on enteral nutrition: surgery including organ transplantation. Clin Nutr 2006; 25: 224-244. [CrossRef]
| APA | GÜNDOĞDU R, YAŞAR U, Ersoy P, ERGÜL E, IŞIKOĞLU S, ERHAN A (2015). Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. , 113 - 117. |
| Chicago | GÜNDOĞDU Rıza Haldun,YAŞAR Uğur,Ersoy Pamir Eren,ERGÜL Emre,IŞIKOĞLU Semra,ERHAN Atilla Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. (2015): 113 - 117. |
| MLA | GÜNDOĞDU Rıza Haldun,YAŞAR Uğur,Ersoy Pamir Eren,ERGÜL Emre,IŞIKOĞLU Semra,ERHAN Atilla Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. , 2015, ss.113 - 117. |
| AMA | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. . 2015; 113 - 117. |
| Vancouver | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. . 2015; 113 - 117. |
| IEEE | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A "Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats." , ss.113 - 117, 2015. |
| ISNAD | GÜNDOĞDU, Rıza Haldun vd. "Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats". (2015), 113-117. |
| APA | GÜNDOĞDU R, YAŞAR U, Ersoy P, ERGÜL E, IŞIKOĞLU S, ERHAN A (2015). Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Ulusal Cerrahi Dergisi, 31(3), 113 - 117. |
| Chicago | GÜNDOĞDU Rıza Haldun,YAŞAR Uğur,Ersoy Pamir Eren,ERGÜL Emre,IŞIKOĞLU Semra,ERHAN Atilla Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Ulusal Cerrahi Dergisi 31, no.3 (2015): 113 - 117. |
| MLA | GÜNDOĞDU Rıza Haldun,YAŞAR Uğur,Ersoy Pamir Eren,ERGÜL Emre,IŞIKOĞLU Semra,ERHAN Atilla Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Ulusal Cerrahi Dergisi, vol.31, no.3, 2015, ss.113 - 117. |
| AMA | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Ulusal Cerrahi Dergisi. 2015; 31(3): 113 - 117. |
| Vancouver | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats. Ulusal Cerrahi Dergisi. 2015; 31(3): 113 - 117. |
| IEEE | GÜNDOĞDU R,YAŞAR U,Ersoy P,ERGÜL E,IŞIKOĞLU S,ERHAN A "Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats." Ulusal Cerrahi Dergisi, 31, ss.113 - 117, 2015. |
| ISNAD | GÜNDOĞDU, Rıza Haldun vd. "Effects of preoperative nutritional support on colonic anastomotic healing in malnourished rats". Ulusal Cerrahi Dergisi 31/3 (2015), 113-117. |
