Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine

Erdogan, Serpil; Yılmaz, Fatma Meriç; FIRAT OĞUZ, Esra; TURKYUREK, CEVDET; ERCAN KARADAĞ, MÜJGAN

Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine

Cevdet TÜRKYÜREK, (Niğde Bor Devlet Hastanesi, Klinik Biyokimya, Niğde, Türkiye)

MÜJGAN ERCAN KARADAĞ, (Ankara Numune Eğitim ve Araştırma Hastanesi, Biyokimya ve Klinik Biyokimya Kliniği, Ankara, Türkiye)

Esra FIRAT OĞUZ, (Ankara Numune Eğitim ve Araştırma Hastanesi, Biyokimya ve Klinik Biyokimya Kliniği, Ankara, Türkiye)

Serpil ERDOĞAN, (Ankara Numune Eğitim ve Araştırma Hastanesi, Biyokimya ve Klinik Biyokimya Kliniği, Ankara, Türkiye)

Fatma Meriç YILMAZ (Ankara Numune Eğitim ve Araştırma Hastanesi, Biyokimya ve Klinik Biyokimya Kliniği, Ankara, Türkiye)

Journal of Clinical and Experimental Investigations

1 1

Yıl: 2015 Cilt: 6 Sayı: 2 Sayfa Aralığı: 91 - 95 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine

Öz:

Amaç: Bu çalışmada sistatin C ve/veya serum kreatinin kullanılarak hesaplanan tahmini glomerüler filtrasyon hızı (eGFR) formüllerini karşılaştırma ve bunların diyabetli hastalarda mikroalbuminürik düzeydeki hasarı tespit edip edemeyeceğinin araştırılması amaçlanmıştır.Yöntemler: Çalışmaya tip 2 DM tanısı olan toplam 99 hasta dahil edilmiştir. Hastalar 24 saatlik idrar albumin miktarına göre normoalbuminürik (grup 1), mikroalbuminürik (grup 2), makroalbuminürik (grup 3) olarak üç gruba ayrılmıştır. Kreatinin klirensi ile Cockcroft-Gault (C-G), MDRD (Modification of Diet in Renal Disease) ve CKD-EPI (The Chronic Kidney Disease Epidemiology), eGFR1, eGFR2, eGFR3 düzeyleri formüllerle hesaplanmıştır.Bulgular: GFR değerlerinde Grup 1-3 ve Grup 2-3 arasında anlamlı farklılık gözlenirken, Grup 1 ile Grup 2 arasında anlamlı fark gözlenmedi. Sistatin C içeren eGFR formüllerinin diğer formüllere göre kreatinin klirensi ile daha anlamlı bir korelasyon gösterdiği bulundu.Sonuç: Diabetik hastaların takibinde Sistatin C bazlı formüllerin kullanımının, hesaplamada sistatin C kullanmayan diğer formüllere göre kreatinin klirens tahmininde daha iyi olduğu bulunmuştur. Ancak hiçbir formül böbrekteki mikroalbuminürik düzeydeki hasarı tespit edememiştir.

Anahtar Kelime:

Konular: Cerrahi

Serum sistatin C ve serum kreatinin kullanılarak hesaplanan tahmini glomerüler filtrasyon hızı değerlerinin karşılaştırılması

Öz:

Objective: In this study, we aimed to compare estimated glomerular filtration rate (eGFR) formulas based on cystatin C and serum creatinine and investigate whether the formulas can detect the renal damage at microalbuminuric level in diabetic patients.Methods: Totally, 99 type 2 diabetic patients were included and divided into 3 groups according to 24 hour urine albumin levels as normoalbuminuric group (group 1), microalbuminuric group (group 2) and macroalbuminuric group (group 3). Creatinine clearance, Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD), The Chronic Kidney Disease Epidemiology (CKD-EPI), eGFR1, eGFR2 and eGFR3 levels were calculated using formulas.Results: There were significant differences between group 1-3 and group 2-3, but there was no significant difference between group 1 and 2 in calculated GFR levels. Cystatin C-based formulas were found to have a better correlation with creatinine clearance. Conclusion: As a result, cystatin C-based formulas were found to predict creatinine clearance better than the other calculated GFR formulas in diabetic patients. However none of the formulas can discriminate the renal damage at microalbuminuric level. J Clin Exp Invest 2015; 6 (2).

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TURKYUREK C, ERCAN KARADAĞ M, FIRAT OĞUZ E, Erdogan S, Yılmaz F (2015). Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. , 91 - 95.
Chicago	TURKYUREK CEVDET,ERCAN KARADAĞ MÜJGAN,FIRAT OĞUZ Esra,Erdogan Serpil,Yılmaz Fatma Meriç Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. (2015): 91 - 95.
MLA	TURKYUREK CEVDET,ERCAN KARADAĞ MÜJGAN,FIRAT OĞUZ Esra,Erdogan Serpil,Yılmaz Fatma Meriç Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. , 2015, ss.91 - 95.
AMA	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. . 2015; 91 - 95.
Vancouver	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. . 2015; 91 - 95.
IEEE	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F "Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine." , ss.91 - 95, 2015.
ISNAD	TURKYUREK, CEVDET vd. "Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine". (2015), 91-95.

APA	TURKYUREK C, ERCAN KARADAĞ M, FIRAT OĞUZ E, Erdogan S, Yılmaz F (2015). Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. Journal of Clinical and Experimental Investigations, 6(2), 91 - 95.
Chicago	TURKYUREK CEVDET,ERCAN KARADAĞ MÜJGAN,FIRAT OĞUZ Esra,Erdogan Serpil,Yılmaz Fatma Meriç Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. Journal of Clinical and Experimental Investigations 6, no.2 (2015): 91 - 95.
MLA	TURKYUREK CEVDET,ERCAN KARADAĞ MÜJGAN,FIRAT OĞUZ Esra,Erdogan Serpil,Yılmaz Fatma Meriç Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. Journal of Clinical and Experimental Investigations, vol.6, no.2, 2015, ss.91 - 95.
AMA	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. Journal of Clinical and Experimental Investigations. 2015; 6(2): 91 - 95.
Vancouver	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine. Journal of Clinical and Experimental Investigations. 2015; 6(2): 91 - 95.
IEEE	TURKYUREK C,ERCAN KARADAĞ M,FIRAT OĞUZ E,Erdogan S,Yılmaz F "Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine." Journal of Clinical and Experimental Investigations, 6, ss.91 - 95, 2015.
ISNAD	TURKYUREK, CEVDET vd. "Comparison of estimated glomerular filtration rate values calculated using serum cystatin C and serum creatinine". Journal of Clinical and Experimental Investigations 6/2 (2015), 91-95.