Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

YILDIRIMKAYA, Metin; HINÇ YILMAZ, Ömer; Yılmaz, Fatma Meriç; ABUŞOĞLU, Sedat; UĞUZ, Nihal; GÜNGÖR TORUN, Oya; TUTKUN, Engin; bal, ceylan; ÇELİK, Hüseyin Tuğrul

Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

Ceylan BAL, (Sağlık Bakanlığı, Ankara Meslek Hastalıkları Hastanesi, Biyokimya Bölümü, Ankara, Türkiye)

Oya GÜNGÖR TORUN, (Hatay Kadın Doğum ve Çocuk Hastanesi, Biyokimya Anabilim Dalı, Hatay, Türkiye)

Hüseyin Tuğrul ÇELİK, (Turgut Özal Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Sedat ABUŞOĞLU, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye)

Nihal UĞUZ, (Ahi Evran Üniversitesi, Eğitim ve Araştırma Hastanesi, Biyokimya Anabilim Dalı, Kırşehir, Türkiye)

Engin TUTKUN, (Ankara Meslek Hastalıkları Hastanesi, Toksikoloji Kliniği, Ankara, Türkiye)

Ömer HINÇ YILMAZ, (Ankara Meslek Hastalıkları Hastanesi, Toksikoloji Kliniği, Ankara, Türkiye)

Fatma Meriç YILMAZ, (Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Metin YILDIRIMKAYA (Ankalab Laboratuarı, Biyokimya Bölümü , Ankara, Türkiye)

Türk Biyokimya Dergisi

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Yıl: 2015 Cilt: 40 Sayı: 3 Sayfa Aralığı: 258 - 264 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

Öz:

Amaç: Çocuklarda akut civa maruziyetine bağlı hızlı glomerüler fitrasyon hızı azalmalarında sistatin C düzeyinin böbrek fonksiyonlarını değerlendirme açısından kreatinine üstün olup olmadığını belirlemeyi amaçladık. Ayrıca kreatinin ve/veya sistatin C kullanılan 8 ayrı glomerular filtrasyon hızı hesaplama formülünü birbiriyle karşılaştırdık.Metod: Civa maruziyeti yaşayan 39 çocuğun serum üre, kreatinin ve sistatin C düzeyleri ölçüldü. Glomerular filtrasyon hızı 8 farklı formülle hesaplandı. Hasta grubu civa seviyelerine göre üç subgruba bölündü.Bulgular: Hastaların sistatin C ve civa düzeyleri kontrol grubundan anlamlı olarak farklı bulundu (p<0.001). Kreatinin ve üre açısından iki grup arasında anlamlı bir fark bulunmadı (p=0.913, p=0.236). Serum kreatinini ve boy kullanılarak veya bunlara ilaveten üre değerleri kullanılarak yapılan GFR hesaplamalarında hasta ve kontrol grupları arasında anlamlı bir fark yokken (sırasıyla, p=0.069, p=0.559, p=0.424, p=0.945 ), yalnızca sistatin C veya buna ek olarak kreatinin, üre ve boyun kullanıldığı GFR hesaplamalarında hasta ve kontrol grupları arasında anlamlı bir fark vardı (sırasıyla, p<0.001, p<0.001, p=0.042, p<0.001). Subgrup analizinde sistatin C sonuçları ile sistatin C kullanılarak hesaplanan dört GFR hesaplamasından üç tanesine ait sonuçlar kontrol grubunda subgruplara göre farklı bulunurken subgruplar arasında farklı bulunmadı.Sonuç: Akut maruziyetlere bağlı hızlı glomerüler fitrasyon hızı azalmalarında sistatin C düzeyi böbrek fonksiyonlarını değerlendirme açısından kreatinine üstündür. Sistatin C kullanılarak oluşturulan formüller glomerüler filtrasyon hızını belirlemede kreatinin ve boy uzunluğu kullanılarak oluşturulan formüllere kıyasla daha iyi sonuç vermektedir.

Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji

Akut civa maruziyeti olan çocuklarda renal fonksiyonların farklı glomerüler fitrasyon hızı formülleriyle değerlendirilmesi

Öz:

Objective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared.Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels.Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant differ ence between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups. Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.

Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	bal c, GÜNGÖR TORUN O, ÇELİK H, ABUŞOĞLU S, UĞUZ N, TUTKUN E, HINÇ YILMAZ Ö, Yılmaz F, YILDIRIMKAYA M (2015). Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. , 258 - 264.
Chicago	bal ceylan,GÜNGÖR TORUN Oya,ÇELİK Hüseyin Tuğrul,ABUŞOĞLU Sedat,UĞUZ Nihal,TUTKUN Engin,HINÇ YILMAZ Ömer,Yılmaz Fatma Meriç,YILDIRIMKAYA Metin Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. (2015): 258 - 264.
MLA	bal ceylan,GÜNGÖR TORUN Oya,ÇELİK Hüseyin Tuğrul,ABUŞOĞLU Sedat,UĞUZ Nihal,TUTKUN Engin,HINÇ YILMAZ Ömer,Yılmaz Fatma Meriç,YILDIRIMKAYA Metin Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. , 2015, ss.258 - 264.
AMA	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. . 2015; 258 - 264.
Vancouver	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. . 2015; 258 - 264.
IEEE	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M "Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury." , ss.258 - 264, 2015.
ISNAD	bal, ceylan vd. "Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury". (2015), 258-264.

APA	bal c, GÜNGÖR TORUN O, ÇELİK H, ABUŞOĞLU S, UĞUZ N, TUTKUN E, HINÇ YILMAZ Ö, Yılmaz F, YILDIRIMKAYA M (2015). Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. Türk Biyokimya Dergisi, 40(3), 258 - 264.
Chicago	bal ceylan,GÜNGÖR TORUN Oya,ÇELİK Hüseyin Tuğrul,ABUŞOĞLU Sedat,UĞUZ Nihal,TUTKUN Engin,HINÇ YILMAZ Ömer,Yılmaz Fatma Meriç,YILDIRIMKAYA Metin Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. Türk Biyokimya Dergisi 40, no.3 (2015): 258 - 264.
MLA	bal ceylan,GÜNGÖR TORUN Oya,ÇELİK Hüseyin Tuğrul,ABUŞOĞLU Sedat,UĞUZ Nihal,TUTKUN Engin,HINÇ YILMAZ Ömer,Yılmaz Fatma Meriç,YILDIRIMKAYA Metin Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. Türk Biyokimya Dergisi, vol.40, no.3, 2015, ss.258 - 264.
AMA	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. Türk Biyokimya Dergisi. 2015; 40(3): 258 - 264.
Vancouver	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury. Türk Biyokimya Dergisi. 2015; 40(3): 258 - 264.
IEEE	bal c,GÜNGÖR TORUN O,ÇELİK H,ABUŞOĞLU S,UĞUZ N,TUTKUN E,HINÇ YILMAZ Ö,Yılmaz F,YILDIRIMKAYA M "Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury." Türk Biyokimya Dergisi, 40, ss.258 - 264, 2015.
ISNAD	bal, ceylan vd. "Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury". Türk Biyokimya Dergisi 40/3 (2015), 258-264.