Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy

dogan, ayse; ERİŞİR, Mine

Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy

Ayşe DOĞAN, (Bitlis Eren Üniversitesi, Sağlık Yüksek Okulu ,Fizik Tedavi ve Rehabilitasyon Bölümü, Bitlis, Türkiye)

Mine ERİŞİR (Fırat Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Elazığ, Türkiye)

Van Veterinary Journal

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Yıl: 2015 Cilt: 26 Sayı: 2 Sayfa Aralığı: 65 - 69 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy

Öz:

Gebelik Süresince Aroclor 1254 (2 mg/kg/gün)'e Maruz Kalan Gebe Ratların Böbrek Beyin ve Karaciğer Dokularında Oksidant/Antioksidant Dengedeki DeğişimlerBu çalışma, Aroclor 1254'e maruz kalan gebe ratların beyin, böbrek ve karaciğer dokularında hem oksidant hem de antioksidant parametreleri araştırmak amacıyla yapılmıştır. Çalışmada ratlar iki gruba ayrılmıştır ve herbir grupta 10 rat bulunmaktadır. Birinci grup, gebe kontrol grubu ve ikinci grup, gebe Aroclor 1254 (2 mg/kg/gün, Aroclor 1254'ün bu dozu 20 gün boyunca subkutan olarak uygulandı). Her grupta yer alan geberatlar 4 hafta boyunca yavrularıyla birlikte muhafaza edilmiştir. Dört haftanın sonunda, ratlar eter anestezi yöntemi yöntemi ile uyutulmuş ve karaciğer, beyin ve böbrek dokuları çıkarılmıştır. Bu dokularda lipit peroksidasyon parametresi malondialdehid (MDA), glutatyon (GSH) seviyeleri ile glutatyon peroksidaz (GSH-Px), katalaz (CAT), süperoksit dismutaz (SOD), glutatyon redüktaz (GR), glutatyon S transferaz (GST) aktiviteleri ölçülmüştür. Çalışma sonucunda karaciğer, böbrek ve beyin dokularında analizi yapılan parametreler açısından iki grup arasında istatistiksel açıdan bir anlamlı bir fark tespit edilememiştir. Yapılan çalışma ile gebelik süresinceuygulananAroclor 1254'ün (2 mg/kg) bir kısmının plasenta yoluyla yavruya geçmesi nedeniyle gebe ratın vücudunda kalan Aroclor 1254'ün miktarının gebe ratda oksidatif hasar oluştarabilecek kadar etkili olmadığı sonucuna varılmıştır. Özellikle yüksek dozda Aroclor 1254'ün gebe ratlara uygulandığı ileri bir çalışma ile; gebe ratlarda oluşabilecek oksidatif hasarın tespitinin yapılabileceği düşünülmektedir

Anahtar Kelime:

Konular: Biyoloji

Gebelik Süresince Aroclor 1254 (2 mg/kg/gün)'e Maruz Kalan Gebe Ratların Böbrek Beyin ve Karaciğer Dokularında Oksidant/Antioksidant Dengedeki Değişimler

Öz:

This study was conducted in order to investigate both oxidant and antioxidant parameters in liver, kidney, and brain tissues of pregnant rats exposed to Aroclor 1254. In the study, rats were divided into two groups, each of which consisted of 10 rats. The first group was the pregnant control group, and the second group was the pregnant Aroclor 1254 (2 mg/kg/day dose of Aroclor 1254 was administered by subcutaneous injection for 20 days). The pregnant rats in each group were kept with their infants for 4 weeks. At the end of the fourth weeks, rats were anesthetized by using ether anesthesia method, and their liver, brain, and kidney tissues were resected. Parameter of lipid peroxidation malondialdehyde (MDA), glutathione (GSH) levels as well as glutathione peroxydase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione S- transferase (GST) activities were measured in these tissues. As a result of the study, no statistically significant difference was determined between two groups in terms of parameters analyzed in liver, kidney, and brain tissues. This study concluded that since a part of Aroclor 1254 (2 mg/kg), which was administered during pregnancy, was transmitted to the infant via placenta, the amount of Aroclor 1254, left in the body of pregnant rat, was not so effective to create oxidative damage in the pregnant rat. It is thought that the oxidative damage which could occur in the pregnant rats could be determined particularly through an advanced study in which a high dosage of Aroclor 1254 is administered to the pregnant rats

Anahtar Kelime:

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	dogan a, ERİŞİR M (2015). Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. , 65 - 69.
Chicago	dogan ayse,ERİŞİR Mine Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. (2015): 65 - 69.
MLA	dogan ayse,ERİŞİR Mine Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. , 2015, ss.65 - 69.
AMA	dogan a,ERİŞİR M Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. . 2015; 65 - 69.
Vancouver	dogan a,ERİŞİR M Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. . 2015; 65 - 69.
IEEE	dogan a,ERİŞİR M "Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy." , ss.65 - 69, 2015.
ISNAD	dogan, ayse - ERİŞİR, Mine. "Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy". (2015), 65-69.

APA	dogan a, ERİŞİR M (2015). Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. Van Veterinary Journal, 26(2), 65 - 69.
Chicago	dogan ayse,ERİŞİR Mine Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. Van Veterinary Journal 26, no.2 (2015): 65 - 69.
MLA	dogan ayse,ERİŞİR Mine Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. Van Veterinary Journal, vol.26, no.2, 2015, ss.65 - 69.
AMA	dogan a,ERİŞİR M Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. Van Veterinary Journal. 2015; 26(2): 65 - 69.
Vancouver	dogan a,ERİŞİR M Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy. Van Veterinary Journal. 2015; 26(2): 65 - 69.
IEEE	dogan a,ERİŞİR M "Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy." Van Veterinary Journal, 26, ss.65 - 69, 2015.
ISNAD	dogan, ayse - ERİŞİR, Mine. "Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy". Van Veterinary Journal 26/2 (2015), 65-69.