A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis
Yıl: 2013 Cilt: 28 Sayı: 2 Sayfa Aralığı: 117 - 122 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis
Öz: Amaç: Bu çalışmanın birincil amacı, ankilozan spondilitli (AS) hastalarda Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI), Bath Ankilozan Spondilit Fonksiyonel İndeksi (BASFI) ve C-reaktif protein (CRP) ve eritrosit sedimentasyon hızını (ESH) içeren iki Ankilozan Spondilit Hastalık Aktivite Skoru (ASDAS) arasındaki muhtemel ilişkiyi araştırmaktır. İkincil amacı ise, hastalık aktivitesi ve fonksiyonel durum açısından cinsiyet farklılıklarını araştırmaktır.Hastalar ve yöntemler: Çalışmaya AS'li 500 hasta (158 kadın, 342 erkek; ort. yaş: 37.2±9.9 yıl; dağılım 15-70 yıl) alındı. Hastalık aktivitesi BASDAI, ASDAS-CRP ve ASDASESH ile değerlendirilirken, fonksiyonel durum BASFI ile değerlendirildi.Bulgular: Ortalama BASDAI, ASDAS-CRP, ASDAS-ESH ve BASFI skoru sırasıyla 3.71±2.26, 1.65±0.83, 2.59±1.12 ve 2.68±2.38 idi. Ankilozan Spondilitli kadın hastaların BASDAI ve ASDAS-ESH değerleri, erkek hastalara kıyasla, anlamlı olarak daha yüksekti. BASDAI ve BASFI skorları, iki ASDAS skoru ile anlamlı düzeyde ilişkili bulundu. Hastaların %46.6'sı, BASDAI skoruna göre yüksek hastalık aktivitesine sahipti ve bu hastalarda hastalık süresi, BASFI ve ASDAS skorları düşük olanlara kıyasla, anlamlı olarak daha yüksekti. Hastalık aktivite indekslerinden ASDAS-CRP skorları her iki cinsiyettede benzerdi.Sonuç: Çalışma bulgularımız, iki ASDAS skorunun hastalık aktivitesi ve fonksiyonel durum ile ilişkili olduğunu göstermektedir. Ankilozan spondilitli hastalarda ASDAS-CRP indeksinin her iki cinsiyeti içeren ancak cinsiyet farklılıklarına ilişkin analiz yapılmayacak ileriki çalışmalarda, hastalık aktivite parametresi olarak kullanılmasının daha uygun olacağı kanısındayız.
Anahtar Kelime: Konular:
Ankilozan Spondilitli Hastalarda Farklı Hastalık Aktivite Parametreleri ve Fonksiyonel Durum Arasındaki Muhtemel İlişki
Öz: Objectives: The primary aim of this study was to assess the possible relationship among the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and two Ankylosing Spondylitis Disease Activity Score (ASDAS) including the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) scores in patients with ankylosing spondylitis (AS). The secondary aim was to investigate gender differences in terms of disease activity scores and functional status. Patients and methods: Five hundred patients (158 females, 342 males; mean age 37.2±9.9 years; range 15 to 70 years) with AS were enrolled. Disease activity was assessed through the BASDAI, ASDAS-CRP and ASDAS-ESR, while functional status was evaluated by the BASFI. Results: The mean BASDAI, ASDAS-CRP, ASDAS-ESR, and BASFI scores were 3.71±2.26, 1.65±0.83, 2.59±1.12, and 2.68±2.38, respectively. The BASDAI and ASDAS-ESR values of the female patients with AS were significantly higher than those of the males. The BASDAI and BASFI were significantly associated with the two ASDAS scores. According to the BASDAI, 46.6% of the patients had a high disease activity and had significantly higher values in terms of symptom duration, compared to those with lower BASFI, and two ASDAS scores. The ASDAS-CRP scores of the disease activity indices were similar in both genders. Conclusion: Our study results suggest that the two ASDAS scores are significantly associated with the disease activity and functional status. We believe that using ASDAS-CRP indices is more suitable for a disease activity parameter in further studies involving patients with AS in both genders, however not analyzing gender differences.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Eroğlu demir S, aytekin e, ÖZGÖNENEL L, rezvani a, PEKİN DOĞAN Y, SAYINER ÇAĞLAR N, Ozaras N, ÇAĞLAR OKUR S, Aydın T, TÜTÜN Ş, GÜLER M (2013). A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. , 117 - 122. |
| Chicago | Eroğlu demir Saliha,aytekin ebru,ÖZGÖNENEL Levent,rezvani aylin,PEKİN DOĞAN Yasemin,SAYINER ÇAĞLAR Nil,Ozaras Nihal,ÇAĞLAR OKUR Sibel,Aydın Teoman,TÜTÜN Şule,GÜLER MUSTAFA A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. (2013): 117 - 122. |
| MLA | Eroğlu demir Saliha,aytekin ebru,ÖZGÖNENEL Levent,rezvani aylin,PEKİN DOĞAN Yasemin,SAYINER ÇAĞLAR Nil,Ozaras Nihal,ÇAĞLAR OKUR Sibel,Aydın Teoman,TÜTÜN Şule,GÜLER MUSTAFA A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. , 2013, ss.117 - 122. |
| AMA | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. . 2013; 117 - 122. |
| Vancouver | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. . 2013; 117 - 122. |
| IEEE | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M "A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis." , ss.117 - 122, 2013. |
| ISNAD | Eroğlu demir, Saliha vd. "A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis". (2013), 117-122. |
| APA | Eroğlu demir S, aytekin e, ÖZGÖNENEL L, rezvani a, PEKİN DOĞAN Y, SAYINER ÇAĞLAR N, Ozaras N, ÇAĞLAR OKUR S, Aydın T, TÜTÜN Ş, GÜLER M (2013). A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28(2), 117 - 122. |
| Chicago | Eroğlu demir Saliha,aytekin ebru,ÖZGÖNENEL Levent,rezvani aylin,PEKİN DOĞAN Yasemin,SAYINER ÇAĞLAR Nil,Ozaras Nihal,ÇAĞLAR OKUR Sibel,Aydın Teoman,TÜTÜN Şule,GÜLER MUSTAFA A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology 28, no.2 (2013): 117 - 122. |
| MLA | Eroğlu demir Saliha,aytekin ebru,ÖZGÖNENEL Levent,rezvani aylin,PEKİN DOĞAN Yasemin,SAYINER ÇAĞLAR Nil,Ozaras Nihal,ÇAĞLAR OKUR Sibel,Aydın Teoman,TÜTÜN Şule,GÜLER MUSTAFA A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.28, no.2, 2013, ss.117 - 122. |
| AMA | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(2): 117 - 122. |
| Vancouver | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(2): 117 - 122. |
| IEEE | Eroğlu demir S,aytekin e,ÖZGÖNENEL L,rezvani a,PEKİN DOĞAN Y,SAYINER ÇAĞLAR N,Ozaras N,ÇAĞLAR OKUR S,Aydın T,TÜTÜN Ş,GÜLER M "A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28, ss.117 - 122, 2013. |
| ISNAD | Eroğlu demir, Saliha vd. "A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis". Turkish Journal of Rheumatology(.)Archives of Rheumatology 28/2 (2013), 117-122. |
