The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis

NICKNAM, Mohammad Hossein; MAHMOUDI, Mahdi; JAMSHIDI, Ahmad Reza; FALLAHI, Sasan; GHARIBDOOST, Farhad; AHMADZADEH, Nooshin

The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis

Sasan FALLAHI, (Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran)

Ahmad Reza JAMSHIDI, (Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran)

Farhad GHARIBDOOST, (Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran)

Mahdi MAHMOUDI, (Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran)

Nooshin AHMADZADEH, (Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran)

Mohammad Hossein NICKNAM (Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran)

Turkish Journal of Rheumatology(.)Archives of Rheumatology

1 0

Yıl: 2013 Cilt: 28 Sayı: 3 Sayfa Aralığı: 181 - 188 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis

Öz:

Amaç: Bu çalışmada İranlı ankilozan spondilit (AS) hastalarında sigara paket yılı ve hastalık aktivitesi, yaşam kalitesi, spinal mobilite ve sakroileit derecelendirmesi ve AS arasındaki ilişki araştırıldı.Hastalar ve yöntemler: Sigara içme durumlarına ve sigara paket yılına göre toplam 160 AS hastası değerlendirildi. Sonuç ölçümleri hastalık aktivitesi, yaşam kalitesi, spinal mobilite ve sakroileit derecelendirmesi olup, sırasıyla Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI), Ankilozan Spondilit Yaşam Kalitesi (ASQoL), Bath Ankilozan Spondilit Metroloji İndeksi (BASMI) ve radyografi ile değerlendirildi.Bulgular: Hafif veya orta düzeyde hastalığı olanlara kıyasla, şiddetli sakroileiti olan hastalarda sigara içme miktarı anlamlı düzeyde daha yüksekti (p=0.001). Tek değişkenli analizde sigara paket yılı ve BASDAI [regression coefficient (B)=0.05, standard error (SE)=0.02, %95 CI: 0.006-0.10; p=0.03], ASQoL (B=0.15, SE=0.06, %95 CI: 0.04-0.26; p=0.007) ve BASMI (B=0.05, SE=0.02, %95 CI: 0.006-0.08; p=0.03) arasında bir ilişki izlendi. Çok değişkenli analizde ise, sigara paket yılı ve BASDAI ve ASQoL arasında anlamlı bir ilişkiye rastlandı.Sonuç: Bir grup İranlı AS hastasında sigara miktarı ve hastalık aktivitesi ve yaşam kalitesi arasında bağımsız bir ilişki olduğu doğrulandı. Ayrıca içilen sigara miktarı ve spinal mobilite arasında da bir ilişki vardı; ancak bu başka ilintili faktörlere bağlıydı. Sigara içen hastalara, daha iyi sonuçlar elde etmeleri için, sigarayı bırakmaları veya daha az içmeleri telkin edilmelidir

Anahtar Kelime:

Konular: Romatoloji

Ankilozan Spondilit Hastalarında Sigara Paket Yılı ve Hastalık Aktivitesi, Yaşam Kalitesi, Spinal Mobilite ve Sakroileit Derecelendirmesi Arasındaki İlişki

Öz:

Objectives: This study aims to investigate the correlation between the pack-years of smoking and disease activity, quality of life, spinal mobility, and sacroiliitis grading and ankylosing spondylitis (AS) in Iranian patients with AS. Patients and methods: A total of 160 AS patients were evaluated according to their smoking status and pack-years of smoking. The outcome measures were disease activity, quality of life, spinal mobility, and sacroiliitis grading, and these were assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Quality of Life (ASQoL), Bath Ankylosing Spondylitis Metrology Index (BASMI), and radiography, respectively. Results: The smoking quantity was significantly higher in the patients with severe sacroiliitis than those with mild or moderate disease (p=0.001). A univariate analysis revealed an association between the pack-years of smoking and the BASDAI [regression coefficient (B)=0.05, standard error (SE)=0.02, 95% CI: 0.006 to 0.10; p=0.03], ASQoL (B=0.15, SE=0.06, 95% CI: 0.04 to 0.26; p=0.007), and BASMI (B=0.05, SE=0.02, 95% CI: 0.006 to 0.08; p=0.03). A multivariate analysis revealed a significant association between the pack- years of smoking and the BASDAI and ASQoL. Conclusion: An independent correlation between smoking quantity with disease activity and quality of life was confirmed in a group of Iranian AS patients. There was also a relationship between smoking quantity and spinal mobility, however, it was dependent on other related factors. Patients who smoke should be encouraged to quit or smoke less to achieve a better outcome

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	FALLAHI S, JAMSHIDI A, GHARIBDOOST F, MAHMOUDI M, AHMADZADEH N, NICKNAM M (2013). The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. , 181 - 188.
Chicago	FALLAHI Sasan,JAMSHIDI Ahmad Reza,GHARIBDOOST Farhad,MAHMOUDI Mahdi,AHMADZADEH Nooshin,NICKNAM Mohammad Hossein The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. (2013): 181 - 188.
MLA	FALLAHI Sasan,JAMSHIDI Ahmad Reza,GHARIBDOOST Farhad,MAHMOUDI Mahdi,AHMADZADEH Nooshin,NICKNAM Mohammad Hossein The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. , 2013, ss.181 - 188.
AMA	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. . 2013; 181 - 188.
Vancouver	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. . 2013; 181 - 188.
IEEE	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M "The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis." , ss.181 - 188, 2013.
ISNAD	FALLAHI, Sasan vd. "The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis". (2013), 181-188.

APA	FALLAHI S, JAMSHIDI A, GHARIBDOOST F, MAHMOUDI M, AHMADZADEH N, NICKNAM M (2013). The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28(3), 181 - 188.
Chicago	FALLAHI Sasan,JAMSHIDI Ahmad Reza,GHARIBDOOST Farhad,MAHMOUDI Mahdi,AHMADZADEH Nooshin,NICKNAM Mohammad Hossein The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology 28, no.3 (2013): 181 - 188.
MLA	FALLAHI Sasan,JAMSHIDI Ahmad Reza,GHARIBDOOST Farhad,MAHMOUDI Mahdi,AHMADZADEH Nooshin,NICKNAM Mohammad Hossein The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.28, no.3, 2013, ss.181 - 188.
AMA	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(3): 181 - 188.
Vancouver	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2013; 28(3): 181 - 188.
IEEE	FALLAHI S,JAMSHIDI A,GHARIBDOOST F,MAHMOUDI M,AHMADZADEH N,NICKNAM M "The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 28, ss.181 - 188, 2013.
ISNAD	FALLAHI, Sasan vd. "The Correlation between Pack-Years of Smoking and Disease Activity, Quality of Life, Spinal Mobility, and Sacroiliitis Grading in Patients with Ankylosing Spondylitis". Turkish Journal of Rheumatology(.)Archives of Rheumatology 28/3 (2013), 181-188.