Yıl: 2010 Cilt: 25 Sayı: 2 Sayfa Aralığı: 91 - 94 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview

Öz:
Tümör nekrozis faktor-alfa (TNF-alfa) inhibitörleri psöriazisin tedavisinde etkili olmasına rağmen TNF-alfa inhibitörleri ile tedavi edilen çeşitli romatizmal hastalıklarda psöriazisin indüklenebildiği bildirilmektedir. Bu olgu serisinde hastaların birinde iki farklı TNF-alfa inhibitörü kullanımına bağlı olmak üzere dört hastada ilaca bağlı olarak gelişen psöriazis vakaları sunulmaktadır. Vaka 1: Ankilozan spondilit tanısıyla takip edilen ve infliksimab tedavisi başlanan 31 yaşında erkek hastada tedavinin 2.haftasında ekstremitelerde eritemli skuamlı lezyonlar gelişti. İki ay sonra tekrar başlanan etanersept tedavisinin 1.ayında ise saçlı deride yoğun olmak üzere tüm gövde ve ekstremitelerde psöriatik lezyonlar gelişti. Vaka 2: Romatoid artritli 53 yaşında bayan hastada etanersept tedavisinin 2.ayında her iki ayak bileği çevresinde eritemli skuamlı lezyonlar oluştu. Vaka 3: Ankilozan spondilitli 34 yaşında bayan hastada infliksimab tedavisinin 10.ayında her iki elinde palmar psöriatik lezyonlar gelişti. Vaka 4: Ankilozan spondilit tanısıyla takip edilen 40 yaşında bayan hastada infliksimab tedavisinin 2.yılında el ve ayaklarında püstüler lezyonlar gelişti. Hastaların hiçbirinde psöriazis için aile öyküsü yoktu. Vakaların üçünde psöriazis tanısı histopatolojik olarak doğrulandı. Romatoid artrit, ankilozan spondilit ve diğer spondiloartritlerde TNF-alfa inhibitörü kullanımına bağlı olarak psöriazis indüklenebilmektedir. En fazla püstüler form ile plak tipi psöriazis görülmekte ve palmoplantar dağılıma rastlanmaktadır
Anahtar Kelime:

Konular: Romatoloji

Tümör Nekrosis Faktor-Alfa inhibitörü Kullanımına Bağlı Olarak Gelişen Psöriazis: Olgu Serisi ve Literatürün Gözden Geçirilmesi

Öz:
Although tumor necrosis factor-alpha (TNF-_) antagonists are shown to be effective in the treatment of psoriasis, induction of psoriatic skin lesions have been seen in patients with different rheumatic conditions who were treated with TNF-_ antagonists. In this case series, we report four cases that developed psoriatic lesions; in one of the cases, psoriasis was associated with two different TNF-_ antagonists. Case 1: A 31-year-old man with ankylosing spondylitis developed erythematous and squamous lesions on his extremities in the 2nd week of infliximab treatment. Two months later he began to receive etanercept, and psoriatic skin lesions developed on the entire trunk and extremities, and predominantly on the scalp after one month. Case 2: A 53-year-old female with rheumatoid arthritis developed psoriatic skin lesions in the ankle region after two months' treatment with etanercept. Case 3: A 34-year-old female with ankylosing spondylitis developed psoriatic lesions on her palms after 10 months' treatment with infliximab. Case 4: A 40-year-old female with ankylosing spondylitis developed pustular lesions on her palms and soles after two years' treatment with infliximab. The patients had no personal or family history of psoriasis. The diagnosis of psoriasis was confirmed by skin biopsy in three of the cases. Psoriatic skin lesions can be induced as a result of treatment with TNF-_ antagonists in patients with rheumatoid arthritis, ankylosing spondylitis and other spondyloarthropathies. The most common form is plaque or pustular pattern with palmoplantar distribution
Anahtar Kelime:

Konular: Romatoloji
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA SARPEL T, Basaran S, DOĞAN AKÇAM F, GÜNAŞTI S, DENLİ Y (2010). Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. , 91 - 94.
Chicago SARPEL TUNAY,Basaran Sibel,DOĞAN AKÇAM Filiz,GÜNAŞTI Suhan,DENLİ Yaşargül Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. (2010): 91 - 94.
MLA SARPEL TUNAY,Basaran Sibel,DOĞAN AKÇAM Filiz,GÜNAŞTI Suhan,DENLİ Yaşargül Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. , 2010, ss.91 - 94.
AMA SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. . 2010; 91 - 94.
Vancouver SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. . 2010; 91 - 94.
IEEE SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y "Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview." , ss.91 - 94, 2010.
ISNAD SARPEL, TUNAY vd. "Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview". (2010), 91-94.
APA SARPEL T, Basaran S, DOĞAN AKÇAM F, GÜNAŞTI S, DENLİ Y (2010). Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 25(2), 91 - 94.
Chicago SARPEL TUNAY,Basaran Sibel,DOĞAN AKÇAM Filiz,GÜNAŞTI Suhan,DENLİ Yaşargül Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. Turkish Journal of Rheumatology(.)Archives of Rheumatology 25, no.2 (2010): 91 - 94.
MLA SARPEL TUNAY,Basaran Sibel,DOĞAN AKÇAM Filiz,GÜNAŞTI Suhan,DENLİ Yaşargül Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.25, no.2, 2010, ss.91 - 94.
AMA SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2010; 25(2): 91 - 94.
Vancouver SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2010; 25(2): 91 - 94.
IEEE SARPEL T,Basaran S,DOĞAN AKÇAM F,GÜNAŞTI S,DENLİ Y "Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 25, ss.91 - 94, 2010.
ISNAD SARPEL, TUNAY vd. "Psoriasis Induced by Tumor Necrosis Factor-Alpha Antagonist Therapy: Case Series and Literature Overview". Turkish Journal of Rheumatology(.)Archives of Rheumatology 25/2 (2010), 91-94.