Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis
Yıl: 2011 Cilt: 26 Sayı: 4 Sayfa Aralığı: 316 - 320 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis
Öz: Amaç: Bu çalışmada semptomatik diz osteoartriti (OA) olan hastalarda kemiğe özgü serum alkalen fosfataz düzeyi ile fonksiyonel durum arasındaki ilişki araştırıldı.Hastalar ve yöntemler: Bu çalışmaya Amerikan Romatoloji Birliği (ACR) kriterlerine göre diz OA tanısı konulan 70 hasta (57 kadın, 13 erkek; ort. yaş 57.5±9.3 yıl; dağılım 48-67 yıl) ile yaş ve cinsiyet açısından uyumlu 30 sağlıklı kontrol (ort. yaş 56.4±7.5 yıl) alındı. Hastalar klinik, laboratuvar ve radyografik yöntemlerle değerlendirildi. Kemik metabolizmasının değerlendirilmesi için kemiğe özgü alkalen fosfataz ve 24 saatlik üriner kalsiyum ve fosfor düzeyleri test edildi. Hastalık şiddeti için Lequesne indeksi, fonksiyonel durum için Western Ontario and McMaster Üniversitesi Osteoartrit İndeksi (WOMAC) kullanıldı.Bulgular: Kemiğe özgü alkalen fosfataz değeri, hasta grubunda ortalama 13.69±4.76 mg/dl idi. Kemiğe özgü alkalen fosfataz değerleri açısından kontrol grubu ile hasta grubu arasında istatistiksel olarak anlamlı bir fark bulunmadı (p=0.584). Hastaların %28.5'inde kemik yapım hızı yüksek idi. Kemiğe özgü alkalen fosfataz ile WOMAC tutukluk skoru arasında ise anlamlı pozitif korelasyon bulundu (p=0.07, r=0.340). Kemiğe özgü alkalen fosfataz ile ağrı, fiziksel fonksiyon, WOMAC total skoru ve Lequesne indeksi arasında anlamlı korelasyon bulunmadı (sırasıyla, p=0.590, r=0.090, p=0.489, r=0.107, p=0.413, r=0.139, p=0.285 r=0.70).Sonuç: Bu çalışmada semptomatik diz osteoartriti olan hastaların yaklaşık 1/4'ünde kemik yapım hızında artış olduğu gösterilmiştir. Kemik yapım hızı ile dizdeki tutukluk arasında anlamlı bir pozitif ilişki bulunmuştur. Ancak hastalık şiddeti ile karşılaştırıldığında kemik yapım hızı, ağrı ve fiziksel fonksiyon arasında herhangi bir ilişki gözlemlenmemiştir.
Anahtar Kelime: Konular:
Semptomatik Diz Osteoartritinde Kemik Yapım Hızı ile Fonksiyonel Durum Arasındaki İlişki
Öz: Objectives: This study aims to investigate the relationship between serum levels of bone-specific alkaline phosphatase and functional status in patients with symptomatic knee osteoarthritis (OA). Patients and methods: Seventy patients (57 females, 13 males; mean age 57.5±9.3 years; range 48 to 67 years) diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria and 30 age- and gender-matched healthy controls (mean age 56.4±7.5 years) were enrolled in the study. Patients were evaluated using clinical, laboratory and radiographic methods. Bone-specific alkaline phosphatase and 24-hour urinary calcium and phosphorus levels were tested to assess bone metabolism. The Lequesne index was used for the severity of disease and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used for the functional status. Results: The mean bone-specific alkaline phosphatase value was 13.69±4.76 mg/dl in the patient group. No statistically significant difference was found between the patient group and the control group in terms of bone-specific alkaline phosphatase values (p=0.584). The bone formation rate was high in 28.5% of the patients. A significantly positive correlation was found between the bone-specific alkaline phosphatase and the WOMAC stiffness scores (p=0.07, r=0.340). No significant correlation was found between the bone-specific alkaline phosphatase and the pain, physical function, and the total scores of the WOMAC and Lequesne index (p=0.590, r=0.090, p=0.489, r=0.107, p=0.413, r=0.139, p=0.285, r=0.70 respectively). Conclusion: In this study, an increase was shown in the bone formation rate in approximately 1/4 of the patients with symptomatic knee osteoarthritis. A significant positive correlation was found between bone formation rate and knee stiffness. However, no relationship was observed between the bone formation rate and pain, physical function, when they were compared with severity of the disease.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E . Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage . Ann Rheum Dis 2001;60:619-26 .
- Bettica P, Cline G, Hart DJ, Meyer J, Spector TD . Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study . Arthritis Rheum 2002;46:3178-84 .
- Karsdal MA, Leeming DJ, Dam EB, Henriksen K, Alexandersen P, Pastoureau P, et al . Should subchondral bone turnover be targeted when treating osteoarthritis? Osteoarthritis Cartilage 2008;16:638-46 .
- Calvo MS, Eyre DR, Gundberg CM . Molecular basis and clinical application of biological markers of bone turnover . Endocr Rev 1996;17:333-68 .
- Takahashi M, Kushida K, Inoue T . Receiver operating characteristic analysis of urinary pyridinium cross-links in arthritis . Br J Rheumatol 1995;34:792-3 .
- Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E . An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline . Osteoarthritis Cartilage 2000;8:180-5 .
- Naitou K, Kushida K, Takahashi M, Ohishi T, Inoue T . Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis . Calcif Tissue Int 2000;66:325-9 .
- Stewart A, Black A, Robins SP, Reid DM . Bone density and bone turnover in patients with osteoarthritis and osteoporosis . J Rheumatol 1999;26:622-6 .
- MacDonald AG, McHenry P, Robins SP, Reid DM . Relationship of urinary pyridinium crosslinks to disease extent and activity in osteoarthritis . Br J Rheumatol 1994;33:16-9 .
- Seibel MJ, Duncan A, Robins SP . Urinary hydroxy- pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases . J Rheumatol 1989;16:964-70 .
- Astbury C, Bird HA, McLaren AM, Robins SP . Urinary excretion of pyridinium crosslinks of collagen correlated with joint damage in arthritis . Br J Rheumatol 1994;33:11-5 .
- Takahashi M, Suzuki M, Naitou K, Miyamoto S, Kushida K . Comparison of free and peptide-bound pyridinoline cross-links excretion in rheumatoid arthritis and osteoarthritis . Rheumatology (Oxford) 1999;38:133-8 .
- Sowers M, Lachance L, Jamadar D, Hochberg MC, Hollis B, Crutchfield M, et al . The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women . Arthritis Rheum 1999;42:483-9 .
- Kucukdeveci A, Koc N . Functional assesment in Osteoarthritis . Turkiye Klinikleri J PMR Special Topics 2008;1:40-7 .
- Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW . Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee . J Rheumatol 1988;15:1833-40 .
- Lequesne MG, Samson M . Indices of severity in osteoarthritis for weight bearing joints . J Rheumatol Suppl 1991;27:16-8 .
- Hunter DJ, Hart D, Snieder H, Bettica P, Swaminathan R, Spector TD . Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins . Rheumatology (Oxford) 2003;42:1311-6 .
- Hulejová H, Spacek P, Klézl Z, Trc T, Adam M . Changes in the articular compartment in advanced osteoarthritis . Acta Chir Orthop Traumatol Cech 2003;70:248-52 . [Abstract]
- Sharif M, George E, Dieppe PA . Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee . Arthritis Rheum 1995;38:78-81 .
- Kim HJ, Lee HM, Kim HS, Park JO, Moon ES, Park H, et al . Bone metabolism in postmenopausal women with lumbar spinal stenosis: analysis of bone mineral density and bone turnover markers . Spine (Phila Pa 1976) 2008;33:2435-9 .
- Campion GV, Delmas PD, Dieppe PA . Serum and synovial fluid osteocalcin (bone gla protein) levels in joint disease . Br J Rheumatol 1989;28:393-8 .
- Kim BJ, Yu YM, Kim EN, Chung YE, Koh JM, Kim GS . Relationship between serum hsCRP concentration and biochemical bone turnover markers in healthy pre- and postmenopausal women . Clin Endocrinol (Oxf) 2007;67:152-8 .
| APA | TEKDÖŞ DEMİRCİOĞLU D, Paker N, SOY BUĞDAYCI D (2011). Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. , 316 - 320. |
| Chicago | TEKDÖŞ DEMİRCİOĞLU DEMET,Paker Nurdan,SOY BUĞDAYCI Derya Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. (2011): 316 - 320. |
| MLA | TEKDÖŞ DEMİRCİOĞLU DEMET,Paker Nurdan,SOY BUĞDAYCI Derya Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. , 2011, ss.316 - 320. |
| AMA | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. . 2011; 316 - 320. |
| Vancouver | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. . 2011; 316 - 320. |
| IEEE | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D "Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis." , ss.316 - 320, 2011. |
| ISNAD | TEKDÖŞ DEMİRCİOĞLU, DEMET vd. "Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis". (2011), 316-320. |
| APA | TEKDÖŞ DEMİRCİOĞLU D, Paker N, SOY BUĞDAYCI D (2011). Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 26(4), 316 - 320. |
| Chicago | TEKDÖŞ DEMİRCİOĞLU DEMET,Paker Nurdan,SOY BUĞDAYCI Derya Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. Turkish Journal of Rheumatology(.)Archives of Rheumatology 26, no.4 (2011): 316 - 320. |
| MLA | TEKDÖŞ DEMİRCİOĞLU DEMET,Paker Nurdan,SOY BUĞDAYCI Derya Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.26, no.4, 2011, ss.316 - 320. |
| AMA | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2011; 26(4): 316 - 320. |
| Vancouver | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2011; 26(4): 316 - 320. |
| IEEE | TEKDÖŞ DEMİRCİOĞLU D,Paker N,SOY BUĞDAYCI D "Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 26, ss.316 - 320, 2011. |
| ISNAD | TEKDÖŞ DEMİRCİOĞLU, DEMET vd. "Relationship Between the Bone Formation Rate and Functional Status in Symptomatic Knee Osteoarthritis". Turkish Journal of Rheumatology(.)Archives of Rheumatology 26/4 (2011), 316-320. |
