A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study

GENCAY CAN, Aslı; günendi, zafer; Beyazova, Mehmet; ÖZYEMİŞÇİ-TAŞKIRAN, Özden

A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study

Özden ÖZYEMİŞÇİ-TAŞKIRAN, (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Aslı GENCAY CAN, (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Zafer GÜNENDİ, (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Mehmet BEYAZOVA (Gazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Rheumatology(.)Archives of Rheumatology

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Yıl: 2012 Cilt: 27 Sayı: 1 Sayfa Aralığı: 24 - 30 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study

Öz:

Amaç: Bu çalışmada sağlıklı bireylerde tek doz indometazinin bilgi işlem hızını etkileyebileceği hipotezi araştırıldı.Hastalar ve yöntemler: Kesitsel, randomize, plasebo kontrollü, çift kör, çapraz geçişli bu çalışmada, 30 sağlıklı erişkin bireye (8 erkek, 22 kadın; ort. yaş 32.4±5.3 yıl; dağılım 24-42 yıl) tek doz 25 mg'lık indometazin (Endol, oral kapsül, DEVA İlaç, Kartepe, Türkiye) ve plasebo uygulandı. İlaç uygulamaları öncesi ve sonrası premotor reaksiyon zamanı ve tepki zamanı çalışmaya kör bir araştırmacı tarafından Ankara Gazi Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı Elektrofizyoloji Laboratuvarı'nda elektromiyografik olarak ölçüldü.Bulgular: Tek doz indometasin öncesi ve sonrası premotor reaksiyon zamanları sırasıyla 169.1±36.3 ve 160.2±29.5 msn (p=0.113) olarak ölçüldü. Tek doz plasebo öncesi ve sonrası premotor reaksiyon zamanları sırasıyla 158.7±35.5 ve 161.5±36.3 msn (p=0.516) olarak ölçüldü. İndometazin ve plasebo grupları arasında premotor reaksiyon zaman ölçümleri açısından istatistiksel anlamlı fark saptanmadı.Sonuç: Tek doz indometazin sağlıklı erişkinlerde premotor reaksiyon zamanı ve tepki zamanı ölçümlerini değiştirmedi. İndometazinin sağlıklı erişkinlerde bilgi işlem hızını etkilemediği düşünülebilir.

Anahtar Kelime:

Konular: Romatoloji

Tek Doz Indometazin Sağlıklı Genç Erişkinlerde Premotor Reaksiyon Zamanını Uzatmıyor: Randomize, Placebo Kontrollü, Çift Kör, Çapraz Geçişli Çalışma

Öz:

Objectives: In this study, we aimed to investigate the hypothesis that a single dose of indomethacin may affect information processing speed in healthy subjects. Patients and methods: In this cross-sectional, randomized, placebo controlled, double-blind, cross-over study, 30 healthy adults (8 males, 22 females; mean age 32.4±5.3 years; range 24 to 42 years) received a single dose of 25 mg indomethacin (Endol, oral capsule, DEVA Pharmaceutics, Kartepe, Turkey) and placebo. Premotor reaction and response times were measured electromyographically before and after the administration of preparations by a blinded researcher in the Electrophysiology Laboratory at Gazi University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara. Results: Premotor reaction time measurements before and after a single dose of indomethacin were 169.1±36.3 and 160.2±29.5 msec, respectively (p=0.113). Premotor reaction time measurements before and after a single dose of placebo were 158.7±35.5 and 161.5±36.3 msec, respectively (p=0.516). There was also no statistically significant difference between premotor reaction time measurements of the indomethacin and placebo groups. Conclusion: A single dose of indomethacin did not change premotor reaction time and response time in healthy adults. This may suggest that indomethacin has no effect on the information processing speed in healthy adults.

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZYEMİŞÇİ-TAŞKIRAN Ö, GENCAY CAN A, günendi z, Beyazova M (2012). A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. , 24 - 30.
Chicago	ÖZYEMİŞÇİ-TAŞKIRAN Özden,GENCAY CAN Aslı,günendi zafer,Beyazova Mehmet A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. (2012): 24 - 30.
MLA	ÖZYEMİŞÇİ-TAŞKIRAN Özden,GENCAY CAN Aslı,günendi zafer,Beyazova Mehmet A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. , 2012, ss.24 - 30.
AMA	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. . 2012; 24 - 30.
Vancouver	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. . 2012; 24 - 30.
IEEE	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M "A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study." , ss.24 - 30, 2012.
ISNAD	ÖZYEMİŞÇİ-TAŞKIRAN, Özden vd. "A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study". (2012), 24-30.

APA	ÖZYEMİŞÇİ-TAŞKIRAN Ö, GENCAY CAN A, günendi z, Beyazova M (2012). A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 27(1), 24 - 30.
Chicago	ÖZYEMİŞÇİ-TAŞKIRAN Özden,GENCAY CAN Aslı,günendi zafer,Beyazova Mehmet A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. Turkish Journal of Rheumatology(.)Archives of Rheumatology 27, no.1 (2012): 24 - 30.
MLA	ÖZYEMİŞÇİ-TAŞKIRAN Özden,GENCAY CAN Aslı,günendi zafer,Beyazova Mehmet A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.27, no.1, 2012, ss.24 - 30.
AMA	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2012; 27(1): 24 - 30.
Vancouver	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2012; 27(1): 24 - 30.
IEEE	ÖZYEMİŞÇİ-TAŞKIRAN Ö,GENCAY CAN A,günendi z,Beyazova M "A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 27, ss.24 - 30, 2012.
ISNAD	ÖZYEMİŞÇİ-TAŞKIRAN, Özden vd. "A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study". Turkish Journal of Rheumatology(.)Archives of Rheumatology 27/1 (2012), 24-30.