Yıl: 2012 Cilt: 27 Sayı: 2 Sayfa Aralığı: 140 - 143 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I

Öz:
Ailesel Akdeniz ateşi (AAA), otoinflamatuvar sendromların bir prototipidir. Fiziksel ve duygusal stres, yağdan zengin beslenme ve menstrüel siklus gibi çeşitli faktörler hastalığı tetikleyebilir. Enfeksiyonlar ve cisplatin gibi bazı ilaçlar, sitokin düzeylerinde değişikliğe yol açarak ataklara zemin hazırlayabilir. Ailesel Akdeniz Ateşi hastalarının birçoğu, ateş ve karın ağrısı ile birlikte kendi kendini sınırlayan tipik ataklar ile başvurur. Bununla birlikte, fenotip II olarak adlandırılan küçük bir hasta grubu, tipik klinik atakların yokluğunda AA tip amiloidoz veya son dönem böbrek yetmezliği ile seyredebilir. Muhtemelen sitokin dengesinde bir değişiklik ile immünsüpresyon tipik bir AAA atağına zemin hazırlayabilir. Bu hastalarda kolşisin tedavisine başlanması, yeni nakledilen greftte amiloidoz gelişiminin önlenmesi için büyük öneme haizdir. Bu yazıda, renal transplantasyon sonrasında muhtemelen immünsüpresanların etkisi nedeniyle, fenotip II'den fenotip I'e geçen nadir bir AAA olgusu sunuldu.
Anahtar Kelime:

Konular: Romatoloji

Renal Transplantasyon Sonrası Ailesel Akdeniz Ateşi Olgusu: Fenotip II?den I?e

Öz:
Familial Mediterranean fever (FMF) is the prototype of autoinflammatory syndromes. Several factors may trigger the disease including physical and emotional stress, fat- rich diet, and menstruel cycle. Infections and some drugs such as cisplatin may result in a change in cytokine levels and may precipitate attacks. Most cases of FMF presents with typical self-limited attacks including fever and abdominal pain. However, a minority of patients, called as phenotype II, presents with amyloidosis AA-type and/or end-stage renal disease in the absence of clinically recognizable attacks. Immunosupression may precipitate a typical FMF attack, possibly through a change in cytokine balance. Initiation of colchicine treatment in these patients is of utmost importance to prevent amyloidosis involvement of the newly transplanted graft. In this article, we present a rare case of FMF who transformed from phenotype II to phenotype I after renal transplantation, most probably due to the effect of immunosuppressants.
Anahtar Kelime:

Konular: Romatoloji
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA SOLAK Y, ATALAY H, POLAT İ, Biyik Z, GAIPOV A, Küçük A, TÜRK S (2012). A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. , 140 - 143.
Chicago SOLAK Yalçın,ATALAY Hüseyin,POLAT İlker,Biyik Zeynep,GAIPOV Abduzhappar,Küçük Adem,TÜRK Süleyman A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. (2012): 140 - 143.
MLA SOLAK Yalçın,ATALAY Hüseyin,POLAT İlker,Biyik Zeynep,GAIPOV Abduzhappar,Küçük Adem,TÜRK Süleyman A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. , 2012, ss.140 - 143.
AMA SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. . 2012; 140 - 143.
Vancouver SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. . 2012; 140 - 143.
IEEE SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S "A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I." , ss.140 - 143, 2012.
ISNAD SOLAK, Yalçın vd. "A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I". (2012), 140-143.
APA SOLAK Y, ATALAY H, POLAT İ, Biyik Z, GAIPOV A, Küçük A, TÜRK S (2012). A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. Turkish Journal of Rheumatology(.)Archives of Rheumatology, 27(2), 140 - 143.
Chicago SOLAK Yalçın,ATALAY Hüseyin,POLAT İlker,Biyik Zeynep,GAIPOV Abduzhappar,Küçük Adem,TÜRK Süleyman A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. Turkish Journal of Rheumatology(.)Archives of Rheumatology 27, no.2 (2012): 140 - 143.
MLA SOLAK Yalçın,ATALAY Hüseyin,POLAT İlker,Biyik Zeynep,GAIPOV Abduzhappar,Küçük Adem,TÜRK Süleyman A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. Turkish Journal of Rheumatology(.)Archives of Rheumatology, vol.27, no.2, 2012, ss.140 - 143.
AMA SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2012; 27(2): 140 - 143.
Vancouver SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I. Turkish Journal of Rheumatology(.)Archives of Rheumatology. 2012; 27(2): 140 - 143.
IEEE SOLAK Y,ATALAY H,POLAT İ,Biyik Z,GAIPOV A,Küçük A,TÜRK S "A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I." Turkish Journal of Rheumatology(.)Archives of Rheumatology, 27, ss.140 - 143, 2012.
ISNAD SOLAK, Yalçın vd. "A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I". Turkish Journal of Rheumatology(.)Archives of Rheumatology 27/2 (2012), 140-143.