Yıl: 2014 Cilt: 16 Sayı: 1 Sayfa Aralığı: 25 - 31 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan

Öz:
The Ghrelin is produced primarily by enteroendocrine cells in the gastric mucosa, and increases gastric emptying in normal subjects. The purpose of this study is to determine the differences in the Ghrelin level during different times along the day, and to assess the differences between the athletes and sedentary at the end of Ramadan fasting period of one month. The results indicated that there were no significant difference among the Ghrelin levels of athletes and sedentary during different times through the day (p>0.05). Significant differences were observed between pre- and post-tests mean Ghrelin scores of subjects (p<0.05) without making a separation as an athlete and sedentary. Also, the results indicated no significant difference between repeated Ghrelin measurements of athletes and sedentary (p>0.05). A significant and positive relationship was found in the middle level at the percentages of BMI and body fat of both groups. Moreover, there were significant differences among BMI scores (p<0.01) and body fat % (p<0.05) of the athletes and sedentary. Consequently, fasting during Ramadan did not cause any differentiation on the serum Ghrelin level of athletes and sedentary, but without group differentiation there was significant increase from the initial measurement to the last measurement of the serum Ghrelin level. There was a significant and positive relationship at middle level between BMI and body fat % of both groups of athletes and sedentary. There was a significant relationship, on the other hand, between BMI and repeated Ghrelin measurements of subjects.
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  • 1. Adlouni A, Ghalim N, Benslimane A, Lacerf Jm, Saite R., Fasting During Ramadan Induces a Marked Increase in HighDensity Lipoprotein Cholesterol and Decrease In Low-Density Lipoprotein Cholesterol. Ann Nutr Metab, 1997; 41: 242–249.
  • 2. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest, 2000; 23: 493–495.
  • 3. Asakawa A, Inui A, Kaga T. et al. Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology, 2001, 120, 337–345.
  • 4. Coskun H, Bozbora A, Ogunc G et al. Adjustable gastric banding in a multicenter study in Turkey. Obes Surg, 2003; 13: 294-6.
  • 5. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS: A preprandial rise in plasma ghrelin level suggests a role in meal initiation in humans. Diabetes, 2001; 50: 1714- 1719.
  • 6. Cummings DE, Weigle DS, Frayo RS.: Plasma ghrelin levels after diet induced weight loss or gastric bypass surgery, N Engl J Med, 2002; 46: 1623-1639.
  • 7. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JPH. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab, 2002; 87: 2984-2987.
  • 8. Fisher BL, Schauer P. Medical and surgical options in the treatment of severe obesity. Am J Surg, 2002; 184: 9S-16S. 9. Hatemi H, Turan N, Arık N, Yumuk V. Türkiye obezite ve hipertansiyon taraması sonuçları (TOHTA). Endokrinolojide Yönelişler Dergisi, 2002; 11(1).
  • 10. Heather JM. The role of circulating ghrelin in the regulation of energy homeostasis in normal weight, healthy young women, Doctoral Thesis, The Pennsylvania State University, 2004. 11. Hosoda H, Kojima M, Kangawa K. Controlling Hunger and Satiety, Molecular Interventions, 2002, December Volume 2, Issue 8.
  • 12. Jackson AS, Pollock ML, Ward A 1980 Generalized equations for predicting body density in women. Med Sci Sports Exerc, 12: 175–182.
  • 13. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes, 2001; 50: 2438–2443.
  • 14. Kraemer RR, Durand RJ, Acevedo EO, Johnson LG, Kraemer GR, Hebert EP, Castracanek VD. Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin. Exp Biol Med, 2004; 229: 240–246.
  • 15. Krarup T, Hansen Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, Jorgensen JO. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol, 2002; 56: 203–206.
  • 16. Leidy HJ, Gardner JK, Frye BR, Snook ML, Schuchert MK, Richard EL, Williams NI. Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. The Journal of Clinical Endocrinology & Metabolism, 2004: 89(6): 2659–2664.
  • 17. Mokdad AH, Serdura MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The continuing epidemic of obesity in the United States. JAMA, 2000; 284: 1650–1651.
  • 18. Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K. Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: Relationships between ghrelin and anabolic/catabolic factors. Circulation, 2001; 104: 2034 –2038.
  • 19. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature, 2001; 409: 194 –198.
  • 20. Shiiya T, Nakazato M, Mizuta A, Date Y, Mondal MS, Tanaka M, Nozoe SI, Hosada H, Kangawa K, Matsukura S: Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab, 2002; 87: 240 -244.
  • 21. Shintani M, Ogawa Y, Ebihara K, Aizawa -Abe M , Miyanaga F , Takaya K, Hayashi T , Inoue G , Hosoda K , Kojima M , Kangawa K, Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001, 50, 227 –232.
  • 22. Soriano -Guillen L, Barrios V, Campos -Barros A, Argente J. Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation. J Pediatr, 2004; 144: 36 -42.
  • 23. Souza MJD, Leidy HJ, O’Donnell E, Lasley B, Williams NI. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones. The Journal of Clinical Endocrinology & Metabolism, 2004; 89(7): 3536–3542.
  • 24. Tschop M, Smiley DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature, 2000; 407: 908 -913.
  • 25. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C: Post -prandial decrease of circulating human ghrelin levels. J Endocrinol Invest, 2001; 24: RC19 - RC21.
  • 26. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab, 2001; 86: 5992 -5995.
  • 27. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR: Ghrelin causes hyperphagia and obesity in rats. Diabetes, 2001; 50: 2540 -2547.
  • 28. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DGA, Ghatei MA, Bloom SR: The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 2000; 141: 4325 -4328.
  • 29. Zoladz JA, Konturek SJ, Duda K, Majerczak J, Sliwowski Z, Grandys M, Bielanski W. Effect of moderate incremental exercise, performed in fed and fasted state on cardiorespiratory variables and leptin and ghrelin concentrations in young. Healthy Men journal of Physiology and Pharmacology, 2005; 56(1): 63-85.
APA EKER H, CİCİOĞLU İ, YETKİN İ, Gülbahar Ö, ALPAY C (2014). Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. , 25 - 31.
Chicago EKER Hasan,CİCİOĞLU İbrahim,YETKİN İlhan,Gülbahar Özlem,ALPAY C. Berkan Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. (2014): 25 - 31.
MLA EKER Hasan,CİCİOĞLU İbrahim,YETKİN İlhan,Gülbahar Özlem,ALPAY C. Berkan Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. , 2014, ss.25 - 31.
AMA EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. . 2014; 25 - 31.
Vancouver EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. . 2014; 25 - 31.
IEEE EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C "Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan." , ss.25 - 31, 2014.
ISNAD EKER, Hasan vd. "Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan". (2014), 25-31.
APA EKER H, CİCİOĞLU İ, YETKİN İ, Gülbahar Ö, ALPAY C (2014). Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. Türk Spor ve Egzersiz Dergisi, 16(1), 25 - 31.
Chicago EKER Hasan,CİCİOĞLU İbrahim,YETKİN İlhan,Gülbahar Özlem,ALPAY C. Berkan Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. Türk Spor ve Egzersiz Dergisi 16, no.1 (2014): 25 - 31.
MLA EKER Hasan,CİCİOĞLU İbrahim,YETKİN İlhan,Gülbahar Özlem,ALPAY C. Berkan Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. Türk Spor ve Egzersiz Dergisi, vol.16, no.1, 2014, ss.25 - 31.
AMA EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. Türk Spor ve Egzersiz Dergisi. 2014; 16(1): 25 - 31.
Vancouver EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan. Türk Spor ve Egzersiz Dergisi. 2014; 16(1): 25 - 31.
IEEE EKER H,CİCİOĞLU İ,YETKİN İ,Gülbahar Ö,ALPAY C "Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan." Türk Spor ve Egzersiz Dergisi, 16, ss.25 - 31, 2014.
ISNAD EKER, Hasan vd. "Studying the serum ghrelin levels of the elite athletes and sedentary controls fasting at the time of Ramadan". Türk Spor ve Egzersiz Dergisi 16/1 (2014), 25-31.